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Pregnenolone

Index Pregnenolone

Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. [1]

Table of Contents

  1. 104 relations: Adolf Butenandt, Adrenal cortex, Adrenal gland, Adrenalectomy, Adrenocorticotropic hormone, AEF0117, Ageing, Agonist, Aldosterone, Allosteric modulator, Androgen, Androstadienol, Androstenedione, Anterior pituitary, Antiandrogen, Biological activity, Biosynthesis, Biotransformation, Blood–brain barrier, Bond cleavage, Brain, Calcium, Cannabinoid, Cannabinoid receptor 1, Cannabis (drug), Chemical castration, Chemical synthesis, Cholesterol, Cholesterol side-chain cleavage enzyme, Corticosteroid, Cyclic compound, CYP17A1, Dehydroepiandrosterone, Dehydroepiandrosterone sulfate, Development of the nervous system, Dietary supplement, Double bond, Endogeny (biology), Enzyme, Estrogen, Estrone, Follicle-stimulating hormone, Functional group, GABAA receptor, Glucocorticoid, Gonad, Hepatocyte, Hydrophobe, Hydroxy group, Hydroxylation, ... Expand index (54 more) »

  2. CB1 receptor antagonists
  3. CB1 receptor negative allosteric modulators
  4. Pregnane X receptor agonists
  5. Steroid hormones

Adolf Butenandt

Adolf Friedrich Johann Butenandt (24 March 1903 – 18 January 1995) was a German biochemist.

See Pregnenolone and Adolf Butenandt

Adrenal cortex

The adrenal cortex is the outer region and also the largest part of the adrenal gland.

See Pregnenolone and Adrenal cortex

Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

See Pregnenolone and Adrenal gland

Adrenalectomy

Adrenalectomy (Latin root Ad "near/at" + renal "related to the kidneys" + Greek ‑ectomy “out-cutting”; sometimes written as ADX for the procedure or resulting state) is the surgical removal of one (unilateral) or both (bilateral) adrenal glands.

See Pregnenolone and Adrenalectomy

Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

See Pregnenolone and Adrenocorticotropic hormone

AEF0117

AEF0117 (3β-(4-methoxybenzyloxy)pregn-5-en-20-one) is a compound derived from pregnenolone by Aelis Farma, which acts as a biased allosteric modulator of the cannabinoid CB1 receptor, representing a new class of compounds referred to as CB1-selective signalling-specific inhibitors (CB1-SSi). Pregnenolone and AEF0117 are ketones.

See Pregnenolone and AEF0117

Ageing

Ageing (or aging in American English) is the process of becoming older.

See Pregnenolone and Ageing

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

See Pregnenolone and Agonist

Aldosterone

Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. Pregnenolone and Aldosterone are pregnanes and steroid hormones.

See Pregnenolone and Aldosterone

Allosteric modulator

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

See Pregnenolone and Allosteric modulator

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

See Pregnenolone and Androgen

Androstadienol

Androstadienol, or androsta-5,16-dien-3β-ol, is a 16-androstene class endogenous steroid, pheromone, and chemical intermediate to several other pheromones that is found in the sweat of both men and women. Pregnenolone and Androstadienol are neurosteroids.

See Pregnenolone and Androstadienol

Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA). Pregnenolone and Androstenedione are pregnane X receptor agonists.

See Pregnenolone and Androstenedione

Anterior pituitary

A major organ of the endocrine system, the anterior pituitary (also called the adenohypophysis or pars anterior) is the glandular, anterior lobe that together with the posterior lobe (posterior pituitary, or the neurohypophysis) makes up the pituitary gland (hypophysis) which, in humans, is located at the base of the brain, protruding off the bottom of the hypothalamus.

See Pregnenolone and Anterior pituitary

Antiandrogen

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.

See Pregnenolone and Antiandrogen

Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

See Pregnenolone and Biological activity

Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

See Pregnenolone and Biosynthesis

Biotransformation

Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds.

See Pregnenolone and Biotransformation

Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

See Pregnenolone and Blood–brain barrier

Bond cleavage

In chemistry, bond cleavage, or bond fission, is the splitting of chemical bonds.

See Pregnenolone and Bond cleavage

Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

See Pregnenolone and Brain

Calcium

Calcium is a chemical element; it has symbol Ca and atomic number 20.

See Pregnenolone and Calcium

Cannabinoid

Cannabinoids are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds.

See Pregnenolone and Cannabinoid

Cannabinoid receptor 1

Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene.

See Pregnenolone and Cannabinoid receptor 1

Cannabis (drug)

Cannabis, also known as marijuana or weed, among other names, is a non-chemically uniform drug from the cannabis plant.

See Pregnenolone and Cannabis (drug)

Chemical castration

Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise.

See Pregnenolone and Chemical castration

Chemical synthesis

Chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products.

See Pregnenolone and Chemical synthesis

Cholesterol

Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Pregnenolone and Cholesterol are neurosteroids and sterols.

See Pregnenolone and Cholesterol

Cholesterol side-chain cleavage enzyme

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage.

See Pregnenolone and Cholesterol side-chain cleavage enzyme

Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Pregnenolone and Corticosteroid are steroid hormones.

See Pregnenolone and Corticosteroid

Cyclic compound

A cyclic compound (or ring compound) is a term for a compound in the field of chemistry in which one or more series of atoms in the compound is connected to form a ring.

See Pregnenolone and Cyclic compound

CYP17A1

Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.

See Pregnenolone and CYP17A1

Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. Pregnenolone and Dehydroepiandrosterone are neurosteroids, pregnane X receptor agonists and Sigma agonists.

See Pregnenolone and Dehydroepiandrosterone

Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. Pregnenolone and Dehydroepiandrosterone sulfate are neurosteroids, pregnane X receptor agonists and Sigma agonists.

See Pregnenolone and Dehydroepiandrosterone sulfate

Development of the nervous system

The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood.

See Pregnenolone and Development of the nervous system

Dietary supplement

A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill, capsule, tablet, powder, or liquid.

See Pregnenolone and Dietary supplement

Double bond

In chemistry, a double bond is a covalent bond between two atoms involving four bonding electrons as opposed to two in a single bond.

See Pregnenolone and Double bond

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See Pregnenolone and Endogeny (biology)

Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

See Pregnenolone and Enzyme

Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Pregnenolone and Estrogen are sterols.

See Pregnenolone and Estrogen

Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. Pregnenolone and Estrone are ketones and sterols.

See Pregnenolone and Estrone

Follicle-stimulating hormone

Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone.

See Pregnenolone and Follicle-stimulating hormone

Functional group

In organic chemistry, a functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions.

See Pregnenolone and Functional group

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Pregnenolone and GABAA receptor

Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

See Pregnenolone and Glucocorticoid

Gonad

A gonad, sex gland, or reproductive gland is a mixed gland that produces the gametes and sex hormones of an organism.

See Pregnenolone and Gonad

Hepatocyte

A hepatocyte is a cell of the main parenchymal tissue of the liver.

See Pregnenolone and Hepatocyte

Hydrophobe

In chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe).

See Pregnenolone and Hydrophobe

Hydroxy group

In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom.

See Pregnenolone and Hydroxy group

Hydroxylation

In chemistry, hydroxylation can refer to.

See Pregnenolone and Hydroxylation

Inguinal orchiectomy

Inguinal orchiectomy (also named orchidectomy) is a specific method of orchiectomy whereby one or both testicles and the full spermatic cord are surgically removed through an incision in the lower lateral abdomen (the "inguinal region").

See Pregnenolone and Inguinal orchiectomy

Insulin

Insulin (from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene.

See Pregnenolone and Insulin

Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.

See Pregnenolone and Ion channel

Isomer

In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element – but distinct arrangements of atoms in space.

See Pregnenolone and Isomer

Ketone

In organic chemistry, a ketone is an organic compound with the structure, where R and R' can be a variety of carbon-containing substituents. Pregnenolone and ketone are ketones.

See Pregnenolone and Ketone

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

See Pregnenolone and Ligand (biochemistry)

Lipophilicity

Lipophilicity (from Greek λίπος "fat" and φίλος "friendly") is the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.

See Pregnenolone and Lipophilicity

Luteinizing hormone

Luteinizing hormone (LH, also known as luteinising hormone, lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland.

See Pregnenolone and Luteinizing hormone

Medication

A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

See Pregnenolone and Medication

Memory

Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed.

See Pregnenolone and Memory

Metabolic intermediate

Metabolic intermediates are molecules that are the precursors or metabolites of biologically significant molecules.

See Pregnenolone and Metabolic intermediate

Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

See Pregnenolone and Metabolism

Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

See Pregnenolone and Metabolite

Methyl group

In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula). In formulas, the group is often abbreviated as Me.

See Pregnenolone and Methyl group

Microtubule

Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells.

See Pregnenolone and Microtubule

Microtubule-associated protein 2

Microtubule-associated protein 2 is a protein in humans that is encoded by the MAP2 gene.

See Pregnenolone and Microtubule-associated protein 2

Mineralocorticoid

Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones.

See Pregnenolone and Mineralocorticoid

Mitochondrion

A mitochondrion is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi.

See Pregnenolone and Mitochondrion

Molar concentration

Molar concentration (also called molarity, amount concentration or substance concentration) is a measure of the concentration of a chemical species, in particular, of a solute in a solution, in terms of amount of substance per unit volume of solution.

See Pregnenolone and Molar concentration

Myelin

Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's electrical wires) to insulate them and increase the rate at which electrical impulses (called action potentials) pass along the axon.

See Pregnenolone and Myelin

Negative feedback

Negative feedback (or balancing feedback) occurs when some function of the output of a system, process, or mechanism is fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances.

See Pregnenolone and Negative feedback

Nerve growth factor

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.

See Pregnenolone and Nerve growth factor

Neurite

A neurite or neuronal process refers to any projection from the cell body of a neuron.

See Pregnenolone and Neurite

Neuroplasticity

Neuroplasticity, also known as neural plasticity or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization.

See Pregnenolone and Neuroplasticity

Neuroprotection

Neuroprotection refers to the relative preservation of neuronal structure and/or function.

See Pregnenolone and Neuroprotection

Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Pregnenolone and Neurosteroid are neurosteroids.

See Pregnenolone and Neurosteroid

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.

See Pregnenolone and NMDA receptor

Pancreatic islets

The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans.

See Pregnenolone and Pancreatic islets

Precursor (chemistry)

In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.

See Pregnenolone and Precursor (chemistry)

Pregnane X receptor

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene.

See Pregnenolone and Pregnane X receptor

Pregnenolone (medication)

Pregnenolone, sold under the brand name Enelone among others, is a medication and supplement as well as a naturally occurring and endogenous steroid. Pregnenolone and Pregnenolone (medication) are CB1 receptor antagonists, Glycine receptor agonists, ketones, neurosteroids, pregnane X receptor agonists, pregnanes and Sigma agonists.

See Pregnenolone and Pregnenolone (medication)

Pregnenolone sulfate

Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone. Pregnenolone and pregnenolone sulfate are neurosteroids, pregnanes and Sigma agonists.

See Pregnenolone and Pregnenolone sulfate

Prenatal development

Prenatal development involves the development of the embryo and of the fetus during a viviparous animal's gestation.

See Pregnenolone and Prenatal development

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Pregnenolone and Progesterone are neurosteroids, pregnane X receptor agonists, pregnanes and steroid hormones.

See Pregnenolone and Progesterone

Progestogen

Progestogens, also sometimes written progestins, progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR).

See Pregnenolone and Progestogen

Schizophrenia

Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.

See Pregnenolone and Schizophrenia

Side chain

In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called the "main chain" or backbone.

See Pregnenolone and Side chain

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

See Pregnenolone and Steroid

Steroid hormone

A steroid hormone is a steroid that acts as a hormone. Pregnenolone and steroid hormone are steroid hormones.

See Pregnenolone and Steroid hormone

Steroid sulfatase

Steroid sulfatase (STS), or steryl-sulfatase (EC 3.1.6.2), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids.

See Pregnenolone and Steroid sulfatase

Steroid sulfotransferase

In enzymology, a steroid sulfotransferase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and phenolic steroid, whereas its two products are adenosine 3',5'-bisphosphate and steroid O-sulfate.

See Pregnenolone and Steroid sulfotransferase

Sulfate

The sulfate or sulphate ion is a polyatomic anion with the empirical formula.

See Pregnenolone and Sulfate

Sulfation

Sulfation is the chemical reaction that entails the addition of SO3 group.

See Pregnenolone and Sulfation

Testosterone

Testosterone is the primary male sex hormone and androgen in males. Pregnenolone and Testosterone are steroid hormones.

See Pregnenolone and Testosterone

Tetrahydrocannabinol

Tetrahydrocannabinol (THC) is a cannabinoid found in cannabis. Pregnenolone and Tetrahydrocannabinol are Glycine receptor agonists.

See Pregnenolone and Tetrahydrocannabinol

Trophic hormone

Trophic hormones are hormones of the anterior lobe of the pituitary.

See Pregnenolone and Trophic hormone

TRPM3

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.

See Pregnenolone and TRPM3

Tubulin

Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.

See Pregnenolone and Tubulin

17α-Hydroxypregnenolone

17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. Pregnenolone and 17α-Hydroxypregnenolone are pregnane X receptor agonists and pregnanes.

See Pregnenolone and 17α-Hydroxypregnenolone

17α-Hydroxyprogesterone

17α-Hydroxyprogesterone (17α-OHP), also known as 17-OH progesterone (17-OHP), or hydroxyprogesterone (OHP), is an endogenous progestogen steroid hormone related to progesterone. Pregnenolone and 17α-Hydroxyprogesterone are pregnane X receptor agonists and pregnanes.

See Pregnenolone and 17α-Hydroxyprogesterone

20α,22R-Dihydroxycholesterol

20α,22R-Dihydroxycholesterol, or (3β)-cholest-5-ene-3,20,22-triol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Pregnenolone and 20α,22R-Dihydroxycholesterol are sterols.

See Pregnenolone and 20α,22R-Dihydroxycholesterol

22R-Hydroxycholesterol

22R-Hydroxycholesterol, or (3β)-cholest-5-ene-3,22-diol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Pregnenolone and 22R-Hydroxycholesterol are sterols.

See Pregnenolone and 22R-Hydroxycholesterol

3β-Dihydroprogesterone

3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4-pregnenolone), is an endogenous steroid. Pregnenolone and 3β-Dihydroprogesterone are ketones, pregnanes and sterols.

See Pregnenolone and 3β-Dihydroprogesterone

3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

See Pregnenolone and 3β-Hydroxysteroid dehydrogenase

See also

CB1 receptor antagonists

CB1 receptor negative allosteric modulators

Pregnane X receptor agonists

Steroid hormones

References

[1] https://en.wikipedia.org/wiki/Pregnenolone

Also known as 5-Pregnenolone, Pregn-5-enolone.

, Inguinal orchiectomy, Insulin, Ion channel, Isomer, Ketone, Ligand (biochemistry), Lipophilicity, Luteinizing hormone, Medication, Memory, Metabolic intermediate, Metabolism, Metabolite, Methyl group, Microtubule, Microtubule-associated protein 2, Mineralocorticoid, Mitochondrion, Molar concentration, Myelin, Negative feedback, Nerve growth factor, Neurite, Neuroplasticity, Neuroprotection, Neurosteroid, NMDA receptor, Pancreatic islets, Precursor (chemistry), Pregnane X receptor, Pregnenolone (medication), Pregnenolone sulfate, Prenatal development, Progesterone, Progestogen, Schizophrenia, Side chain, Steroid, Steroid hormone, Steroid sulfatase, Steroid sulfotransferase, Sulfate, Sulfation, Testosterone, Tetrahydrocannabinol, Trophic hormone, TRPM3, Tubulin, 17α-Hydroxypregnenolone, 17α-Hydroxyprogesterone, 20α,22R-Dihydroxycholesterol, 22R-Hydroxycholesterol, 3β-Dihydroprogesterone, 3β-Hydroxysteroid dehydrogenase.