Table of Contents
85 relations: Aciclovir, Activation, Active metabolite, ADME, Aglycone, Antihistamine, Aripiprazole lauroxil, Arsphenamine, Aspirin, Bacampicillin, Bambuterol, Bayer, Benzhydrocodone, Bioavailability, Biological activity, Blood, Captopril, Carbamazepine, Carisoprodol, Chemotherapy, Chloramphenicol, Circulatory system, Codeine, Cyclophosphamide, Dabigatran, DEPT (medicine), Desloratadine, Dipivefrine, Drug metabolism, Enzyme, Felix Hoffmann, Fexofenadine, Fluorouracil, Food and Drug Administration, Fosfestrol, Fosphenytoin, Fursultiamine, Gabapentin enacarbil, Gastrointestinal tract, Gerhard Domagk, Glucoside, Glucuronide, Glycoside, Heroin, Immunotherapy, International Union of Pure and Applied Chemistry, Isavuconazonium, L-DOPA, Latanoprostene bunod, Leflunomide, ... Expand index (35 more) »
Aciclovir
Aciclovir, also known as acyclovir, is an antiviral medication.
Activation
In chemistry and biology, activation is the process whereby something is prepared or excited for a subsequent reaction.
Active metabolite
An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical. Prodrug and active metabolite are pharmacokinetics.
See Prodrug and Active metabolite
ADME
ADME is the four-letter abbreviation (acronym) for ''absorption'', ''distribution'', metabolism, and excretion, and is mainly used in fields such as pharmacokinetics and pharmacology. Prodrug and ADME are pharmacokinetics.
See Prodrug and ADME
Aglycone
An aglycone (aglycon or genin) is the chemical compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom.
Antihistamine
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies.
Aripiprazole lauroxil
Aripiprazole lauroxil, sold under the brand name Aristada, is a long-acting injectable atypical antipsychotic that was developed by Alkermes. Prodrug and Aripiprazole lauroxil are prodrugs.
See Prodrug and Aripiprazole lauroxil
Arsphenamine
Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis.
Aspirin
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic.
Bacampicillin
Bacampicillin (INN) is a penicillin antibiotic. Prodrug and Bacampicillin are prodrugs.
Bambuterol
Bambuterol (INN) is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. Prodrug and Bambuterol are prodrugs.
Bayer
Bayer AG (English:, commonly pronounced) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world.
Benzhydrocodone
Benzhydrocodone (INN) (contracted from '''benz'''oate-hydrocodone) is an opioid prodrug of the morphinan class.
See Prodrug and Benzhydrocodone
Bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.
See Prodrug and Bioavailability
Biological activity
In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.
See Prodrug and Biological activity
Blood
Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells.
Captopril
Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
Carbamazepine
Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain. Prodrug and Carbamazepine are prodrugs.
Carisoprodol
Carisoprodol, sold under the brand name Soma among others, is a medication used for musculoskeletal pain. Prodrug and Carisoprodol are prodrugs.
Chemotherapy
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.
Chloramphenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.
See Prodrug and Chloramphenicol
Circulatory system
The circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate.
See Prodrug and Circulatory system
Codeine
Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. Prodrug and Codeine are prodrugs.
Cyclophosphamide
Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. Prodrug and Cyclophosphamide are prodrugs.
See Prodrug and Cyclophosphamide
Dabigatran
Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. It is used as an alternative to warfarin and does not require monitoring by blood tests.
DEPT (medicine)
Directed enzyme prodrug therapy (DEPT) uses enzymes artificially introduced into the body to convert prodrugs, which have no or poor biologically activity, to the active form in the desired location within the body.
See Prodrug and DEPT (medicine)
Desloratadine
Desloratadine.
Dipivefrine
Dipivefrine (INN) or dipivefrin (USAN), trade name Propine among others, is a prodrug of epinephrine, and is used to treat open-angle glaucoma. Prodrug and dipivefrine are prodrugs.
Drug metabolism
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. Prodrug and drug metabolism are pharmacokinetics.
See Prodrug and Drug metabolism
Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
Felix Hoffmann
Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesising diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin".
See Prodrug and Felix Hoffmann
Fexofenadine
Fexofenadine, sold under the brand name Allegra among others, is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria.
Fluorouracil
Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.
See Prodrug and Food and Drug Administration
Fosfestrol
Fosfestrol, sold under the brand name Honvan and also known as diethylstilbestrol diphosphate (DESDP), is an estrogen medication which is used in the treatment of prostate cancer in men. Prodrug and Fosfestrol are prodrugs.
Fosphenytoin
Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. Prodrug and fosphenytoin are prodrugs.
Fursultiamine
Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Prodrug and Fursultiamine are prodrugs.
Gabapentin enacarbil
Gabapentin enacarbil (Horizant, Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. Prodrug and gabapentin enacarbil are prodrugs.
See Prodrug and Gabapentin enacarbil
Gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.
See Prodrug and Gastrointestinal tract
Gerhard Domagk
Gerhard Johannes Paul Domagk (30 October 1895 – 24 April 1964) was a German pathologist and bacteriologist.
See Prodrug and Gerhard Domagk
Glucoside
A glucoside is a glycoside that is chemically derived from glucose.
Glucuronide
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.
Glycoside
In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond.
Heroin
Heroin, also known as diacetylmorphine and diamorphine among other names, is a morphinan opioid substance synthesized from the dried latex of the Papaver somniferum plant; it is mainly used as a recreational drug for its euphoric effects. Prodrug and Heroin are prodrugs.
Immunotherapy
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system.
International Union of Pure and Applied Chemistry
The International Union of Pure and Applied Chemistry (IUPAC) is an international federation of National Adhering Organizations working for the advancement of the chemical sciences, especially by developing nomenclature and terminology.
See Prodrug and International Union of Pure and Applied Chemistry
Isavuconazonium
Isavuconazonium, sold under the brand name Cresemba, is a systemic antifungal medication of the triazole class which is used to treat invasive aspergillosis and mucormycosis. Prodrug and Isavuconazonium are prodrugs.
See Prodrug and Isavuconazonium
L-DOPA
-DOPA, also known as levodopa and -3,4-dihydroxyphenylalanine, is made and used as part of the normal biology of some plants and animals, including humans.
Latanoprostene bunod
Latanoprostene bunod, sold under the brand name Vyzulta, is an ophthalmic medication used for the reduction of intraocular pressure in people with open-angle glaucoma or ocular hypertension.
See Prodrug and Latanoprostene bunod
Leflunomide
Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. Prodrug and Leflunomide are prodrugs.
Lisdexamfetamine
Lisdexamfetamine, sold under the brand names Vyvanse and Elvanse among others, is a stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults and for moderate-to-severe binge eating disorder in adults.
See Prodrug and Lisdexamfetamine
Loratadine
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies.
Medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
Mercaptopurine
Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases.
See Prodrug and Mercaptopurine
Mitomycins
The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name.
Molsidomine
Molsidomine (trade names Corvasal, Corvaton and many others) is an orally active, long acting vasodilating drug used to treat angina pectoris.
Morphine
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum).
Nanoparticle
A nanoparticle or ultrafine particle is a particle of matter 1 to 100 nanometres (nm) in diameter.
Oxyphenisatine
Oxyphenisatine (or oxyphenisatin) is a laxative.
See Prodrug and Oxyphenisatine
Paliperidone
Paliperidone, sold under the brand name Invega among others, is an atypical antipsychotic.
Paul Ehrlich
Paul Ehrlich (14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology and antimicrobial chemotherapy.
Pfizer–BioNTech COVID-19 vaccine
The Pfizer–BioNTech COVID-19 vaccine, sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with the American company Pfizer to carry out clinical trials, logistics, and manufacturing.
See Prodrug and Pfizer–BioNTech COVID-19 vaccine
Phenacetin
Phenacetin (acetophenetidin, N-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887.
Phosphorylation
In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion.
See Prodrug and Phosphorylation
Pralidoxime
Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase.
Precursor (chemistry)
In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.
See Prodrug and Precursor (chemistry)
Primidone
Primidone, sold under various brand names, is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors.
Prontosil
Prontosil is an antibacterial drug of the sulfonamide group. Prodrug and Prontosil are prodrugs.
Psilocybin
Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi.
Pure and Applied Chemistry
Pure and Applied Chemistry is the official journal for the International Union of Pure and Applied Chemistry (IUPAC).
See Prodrug and Pure and Applied Chemistry
Sahachiro Hata
was a prominent Japanese bacteriologist who researched the bubonic plague under Kitasato Shibasaburō and assisted in developing the Arsphenamine drug in 1909 in the laboratory of Paul Ehrlich.
See Prodrug and Sahachiro Hata
Salicin
Salicin is an alcoholic β-glucoside.
Salicylic acid
Salicylic acid is an organic compound with the formula HOC6H4COOH.
See Prodrug and Salicylic acid
Selexipag
Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH).
Serdexmethylphenidate
Serdexmethylphenidate is a prodrug of dexmethylphenidate created by the pharmaceutical company KemPharm (now Zevra Therapeutics).
See Prodrug and Serdexmethylphenidate
Sofosbuvir
Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is taken by mouth. Prodrug and Sofosbuvir are prodrugs.
Sulfanilamide
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug.
Sulfasalazine
Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease.
Sulfonamide (medicine)
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs.
See Prodrug and Sulfonamide (medicine)
Sulindac
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed as Clinoril. Prodrug and Sulindac are prodrugs.
Tedizolid
Tedizolid, sold under the brand name Sivextro is an oxazolidinone-class antibiotic.
Tenofovir disoproxil
Tenofovir disoproxil, sold under the brand name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Prodrug and Tenofovir disoproxil are prodrugs.
See Prodrug and Tenofovir disoproxil
Terfenadine
Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. Prodrug and Terfenadine are prodrugs.
Toxication
Toxication, toxification or toxicity exaltation is the conversion of a chemical compound into a more toxic form in living organisms or in substrates such as soil or water. Prodrug and Toxication are pharmacokinetics.
Zidovudine
Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS.
References
Also known as Conversion in vivo, In vivo conversion, Inactive prodrug, Pro-drug, Prodrugs.