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Progesterone receptor

Index Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. [1]

45 relations: Aglepristone, Antiprogestogen, Asoprisnil, Asoprisnil ecamate, C-terminus, Chromosome 11, DNA, DNA-binding domain, Drospirenone, Dydrogesterone, Endogeny (biology), Gene, KLF9, Levonorgestrel, Lilopristone, Lonaprisan, Mammary gland, Medroxyprogesterone acetate, Megestrol acetate, Membrane progesterone receptor, Messenger RNA, Mifepristone, N-terminus, Norethisterone, Nuclear receptor, Nuclear receptor co-repressor 2, Onapristone, Organic compound, Phytoprogestogen, Progesterone, Progesterone receptor A, Progesterone receptor B, Progesterone receptor C, Progestogen, Protein dimer, Protein–protein interaction, Puberty, Ribosome, Selective progesterone receptor modulator, Telapristone, Toripristone, Transcription (biology), UBE3A, Ulipristal acetate, Vilaprisan.

Aglepristone

Aglepristone (brand name Alizine; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine.

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Antiprogestogen

Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body.

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Asoprisnil

Asoprisnil (INN; developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical Products for the treatment of uterine fibroids.

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Asoprisnil ecamate

Asoprisnil ecamate (INN) (developmental code name J-956) is a synthetic, steroidal selective progesterone receptor modulator (SPRM) which was under development for the treatment of endometriosis, uterine fibroids, and menopausal symptoms but was discontinued.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Chromosome 11

Chromosome 11 is one of the 23 pairs of chromosomes in humans.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA-binding domain

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.

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Drospirenone

Drospirenone, sold under the brand names Yasmin and Angeliq among others, is a progestin medication which is used in birth control pills and in menopausal hormone therapy. The medication is available only in combination with an estrogen. It is taken by mouth. Drospirenone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has additional antimineralocorticoid and antiandrogenic activity and no other important hormonal activity. Drospirenone was introduced for medical use in 2000. It is available widely throughout the world. The medication is sometimes referred to as a "fourth-generation" progestin. It is available as a generic medication.https://www.drugs.com/availability/generic-yasmin.html.

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Dydrogesterone

Dydrogesterone, sold under the brand name Duphaston among others, is a progestin medication which is used for a variety of indications, including threatened or recurrent miscarriage during pregnancy, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhea, irregular cycles, premenstrual syndrome, and as a component of menopausal hormone therapy.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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KLF9

Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene.

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Levonorgestrel

Levonorgestrel is a hormonal medication which is used in a number of birth control methods.

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Lilopristone

Lilopristone (INN) (developmental code names ZK-98734, ZK-734) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and was patented in 1985.

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Lonaprisan

Lonaprisan (INN, USAN) (developmental code names ZK-230211, BAY 86-5044, ZK-PRA) is a synthetic, steroidal antiprogestogen which was under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis, dysmenorrhea, and breast cancer but was discontinued.

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Mammary gland

A mammary gland is an exocrine gland in mammals that produces milk to feed young offspring.

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Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA), sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type.

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Megestrol acetate

Megestrol acetate (MGA), sold under the brand name Megace among others, is a progestin medication which is used mainly as an appetite stimulant to treat wasting syndromes such as cachexia.

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Membrane progesterone receptor

Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Mifepristone

Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Norethisterone

Norethisterone, also known as norethindrone and sold under the brand names Aygestin and Primolut N among many others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.

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Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.

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Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains.

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Onapristone

Onapristone (INN) (developmental code names ZK-89299, ZK-299) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and described in 1984 but was never marketed.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Phytoprogestogen

Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.

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Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

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Progesterone receptor A

The progesterone receptor A (PR-A) is one of three known isoforms of the progesterone receptor (PR), the main biological target of the endogenous progestogen sex hormone progesterone.

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Progesterone receptor B

The progesterone receptor B (PR-B) is one of three known isoforms of the progesterone receptor (PR), the main biological target of the endogenous progestogen sex hormone progesterone.

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Progesterone receptor C

The progesterone receptor C (PR-C) is one of three known isoforms of the progesterone receptor (PR), the main biological target of the endogenous progestogen sex hormone progesterone.

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Progestogen

Progestogens, also sometimes spelled progestagens or gestagens, are a class of steroid hormones that bind to and activate the progesterone receptor (PR).

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Puberty

Puberty is the process of physical changes through which a child's body matures into an adult body capable of sexual reproduction.

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Ribosome

The ribosome is a complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation).

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Selective progesterone receptor modulator

A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor.

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Telapristone

Telapristone, as telapristone acetate (proposed brand names Proellex, Progenta; former code name CDB-4124), is a synthetic, steroidal selective progesterone receptor modulator (SPRM) related to mifepristone which is under development by Repros Therapeutics for the treatment of breast cancer, endometriosis, and uterine fibroids.

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Toripristone

Toripristone (INN) (developmental code name RU-40555) is a synthetic, steroidal antiglucocorticoid as well as antiprogestogen which was never marketed.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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UBE3A

Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene.

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Ulipristal acetate

Ulipristal acetate, sold under the brand name Ella among others, is a medication used for emergency birth control and uterine fibroids.

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Vilaprisan

Vilaprisan (INN, USAN) (developmental code name BAY-1002670) is a synthetic, steroidal selective progesterone receptor modulator (SPRM) which is under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis and uterine fibroids.

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Redirects here:

NR3C3, Nr3c3, PGR (gene), Progesterone receptors, Progestin receptor, Receptors, progesterone.

References

[1] https://en.wikipedia.org/wiki/Progesterone_receptor

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