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54 relations: Abdominal pain, Acetylcholine, Acetylcholinesterase, Agonist, Benzamide, Benzofuran, Bifidobacterium animalis, Bifidobacterium breve, Bloating, Cinitapride, Cisapride, Constipation, Defecation, Domperidone, Drug, Enzyme, Enzyme inhibitor, Erythromycin, Gastritis, Gastrointestinal disease, Gastrointestinal tract, Gastroparesis, Goodman & Gilman's The Pharmacological Basis of Therapeutics, Heart arrhythmia, Heartburn, HERG, Indigestion, Intestinal pseudo-obstruction, Irritable bowel syndrome, Itopride, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Levosulpiride, Linaclotide, Metoclopramide, Mitemcinal, Mosapride, Motility, Muscarinic acetylcholine receptor M1, Nausea, Pathophysiology, Peristalsis, Physiology, Prucalopride, Renzapride, Selective serotonin reuptake inhibitor, Serotonin, Small intestinal bacterial overgrowth, ..., Small intestine, Tegaserod, Vomiting, 5-HT4 receptor. Expand index (4 more) »
Abdominal pain
Abdominal pain, also known as a stomach ache, is a symptom associated with both non-serious and serious medical issues.
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Acetylcholine
Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical message released by nerve cells to send signals to other cells.
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Acetylcholinesterase
Acetylcholinesterase, encoded by HGNC gene ACHE; EC 3.1.1.7) is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Benzamide
Benzamide is an off-white solid with the chemical formula of C6H5CONH2.
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Benzofuran
Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings.
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Bifidobacterium animalis
Bifidobacterium animalis is a gram-positive, anaerobic, rod-shaped bacterium of the Bifidobacterium genus which can be found in the large intestines of most mammals, including humans.
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Bifidobacterium breve
Bifidobacterium breve is a bacterial species of the genus Bifidobacterium which has probiotic properties.
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Bloating
Abdominal bloating is a symptom that can appear at any age, generally associated with functional gastrointestinal disorders or organic diseases, but can also appear alone.
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Cinitapride
Cinitapride (trade names Cintapro, Pemix) is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain.
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Cisapride
Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract.
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Constipation
Constipation refers to bowel movements that are infrequent or hard to pass.
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Defecation
Defecation is the final act of digestion, by which organisms eliminate solid, semisolid, or liquid waste material from the digestive tract via the anus.
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Domperidone
Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D2 receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue.
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Drug
A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme inhibitor
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Erythromycin
Erythromycin is an antibiotic useful for the treatment of a number of bacterial infections.
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Gastritis
Gastritis is inflammation of the lining of the stomach.
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Gastrointestinal disease
Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus, stomach, small intestine, large intestine and rectum, and the accessory organs of digestion, the liver, gallbladder, and pancreas.
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Gastrointestinal tract
The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.
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Gastroparesis
Gastroparesis (GP also called delayed gastric emptying) is a medical condition consisting of a paresis (partial paralysis) of the stomach, resulting in food remaining in the stomach for an abnormally long time.
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Goodman & Gilman's The Pharmacological Basis of Therapeutics
Goodman & Gilman's The Pharmacological Basis of Therapeutics, commonly referred to as the Blue Bible or Goodman & Gilman, is a textbook of pharmacology originally authored by Louis S. Goodman and Alfred Gilman.
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Heart arrhythmia
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
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Heartburn
Heartburn, also known as acid indigestion, is a burning sensation in the central chest or upper central abdomen.
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HERG
hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel.
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Indigestion
Indigestion, also known as dyspepsia, is a condition of impaired digestion.
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Intestinal pseudo-obstruction
Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the intestines to push food through.
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Irritable bowel syndrome
Irritable bowel syndrome (IBS) is a group of symptoms—including abdominal pain and changes in the pattern of bowel movements without any evidence of underlying damage.
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Itopride
Itopride (INN) (brand name Ganaton) is a prokinetic benzamide derivative unlike metoclopramide or domperidone.
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Lactobacillus casei
Lactobacillus casei is a species of genus Lactobacillus found in the human intestine and mouth.
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Lactobacillus plantarum
Lactobacillus plantarum is a widespread member of the genus Lactobacillus, commonly found in many fermented food products as well as anaerobic plant matter.
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Lactobacillus reuteri
Lactobacillus reuteri is a Gram-positive bacterium that naturally inhabits the gut of mammals and birds.
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Lactobacillus rhamnosus
Lactobacillus rhamnosus is a bacterium that originally was considered to be a subspecies of L. casei, but later genetic research found it to be a species of its own.
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Levosulpiride
Levosulpiride is a substituted benzamide antipsychotic, reported to be a selective antagonist of dopamine D2 receptor activity on both central and peripheral levels.
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Linaclotide
Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella elsewhere) is a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause.
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Metoclopramide
Metoclopramide is a medication used mostly for stomach and esophageal problems.
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Mitemcinal
Mitemcinal (GM-611 or 3'-N-dimethyl-11-deoxy-3'-N-isopropyl-12-O-methyl-11-oxo-8,9-didehydroerythromycin) is a motilin agonist derived from the macrolide antibiotic, erythromycin.
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Mosapride
Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
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Motility
Motility is the ability of an organism to move independently, using metabolic energy.
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Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
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Nausea
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
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Pathophysiology
Pathophysiology or physiopathology is a convergence of pathology with physiology.
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Peristalsis
Peristalsis is a radially symmetrical contraction and relaxation of muscles that propagates in a wave down a tube, in an anterograde direction.
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Physiology
Physiology is the scientific study of normal mechanisms, and their interactions, which work within a living system.
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Prucalopride
Prucalopride, brand name Resolor among others, is a drug acting as a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.
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Renzapride
Renzapride is a gastroprokinetic agent and antiemetic which acts as a full 5-HT4 full agonist and 5-HT3 antagonist.
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Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Small intestinal bacterial overgrowth
Small intestine bacterial overgrowth (SIBO), also termed bacterial overgrowths, or small bowel bacterial overgrowth syndrome (SBBOS), is a disorder of excessive bacterial growth in the small intestine.
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Small intestine
The small intestine or small bowel is the part of the gastrointestinal tract between the stomach and the large intestine, and is where most of the end absorption of food takes place.
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Tegaserod
Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation.
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Vomiting
Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.
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5-HT4 receptor
5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.
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Gastrokinetic, Gastrokinetics, Gastroprokinetic, Gastroprokinetic agent, Prokinetic, Prokinetic drugs, Prokinetics, Propulsive.
References
[1] https://en.wikipedia.org/wiki/Prokinetic_agent
