73 relations: Agonist, Androgen, Antiandrogen, Antimineralocorticoid, Argentina, Benign tumor, Biological half-life, Biological target, Biotransformation, Blood plasma, Breast disease, Breast pain, Cmax (pharmacology), Decidualization, Demegestone, Derivative (chemistry), Double bond, Dysmenorrhea, Estrogen (medication), Excretion, France, Glucocorticoid, Glucuronide, Gynaecology, Hormone, Human serum albumin, Hydroxylation, Irregular menstruation, Isomer, Ligand (biochemistry), Liver, Luteal phase, Menopause, Menstrual disorder, Metabolism, Metabolite, Mineralocorticoid, Neurosteroid, Nicotinic acetylcholine receptor, Oral administration, Organic compound, Ovulation, Pharmacodynamics, Plasma protein binding, Portugal, Postmenopausal hormone therapy, Premenstrual syndrome, Prodrug, Progesterone, Progesterone (medication), ..., Progesterone receptor, Progestin, Progestogen, Radioligand, Redox, Roussel Uclaf, Scientific method, Serum albumin, Sex hormone-binding globulin, Side effect, Stereoselectivity, Steroid, Sulfate, Trademark distinctiveness, Transcortin, Trimegestone, Tunisia, Urine, 11-Deoxycorticosterone, 17α-Methyl-19-norprogesterone, 17α-Methylprogesterone, 19-Norpregnane, 19-Norprogesterone. Expand index (23 more) » « Shrink index
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.
An antimineralocorticoid, MCRA, or an aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.
Argentina, officially the Argentine Republic (República Argentina), is a federal republic located mostly in the southern half of South America.
A benign tumor is a mass of cells (tumor) that lacks the ability to invade neighboring tissue or metastasize.
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.
Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound.
Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension; this makes plasma the extracellular matrix of blood cells.
Breast diseases can be classified either with disorders of the integument, or disorders of the reproductive system.
Breast pain is a medical symptom that is most often associated with a developing disease or condition of the breast.
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
Decidualization is a process that results in significant changes to cells of the endometrium in preparation for, and during, pregnancy.
Demegestone, sold under the brand name Lutionex, is a progestin medication which was previously used to treat luteal insufficiency but is now no longer marketed.
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.
A double bond in chemistry is a chemical bond between two chemical elements involving four bonding electrons instead of the usual two.
Dysmenorrhea, also known as painful periods, or menstrual cramps, is pain during menstruation.
An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.
Excretion is the process by which metabolic waste is eliminated from an organism.
France, officially the French Republic (République française), is a sovereign state whose territory consists of metropolitan France in Western Europe, as well as several overseas regions and territories.
Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.
Gynaecology or gynecology (see spelling differences) is the medical practice dealing with the health of the female reproductive systems (vagina, uterus, and ovaries) and the breasts.
A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.
Human serum albumin is the serum albumin found in human blood.
Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.
Irregular menstruation is a menstrual disorder whose manifestations include irregular cycle lengths as well as metrorrhagia (vaginal bleeding between expected periods).
An isomer (from Greek ἰσομερής, isomerès; isos.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
The luteal phase is the latter phase of the menstrual cycle (in humans and a few other animals) or the earlier phase of the estrous cycle (in other placental mammals).
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.
A menstrual disorder is an abnormal condition in a woman's menstrual cycle.
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
A metabolite is the intermediate end product of metabolism.
Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones.
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.
Nicotinic acetylcholine receptors, or nAChRs, are receptor proteins that respond to the neurotransmitter acetylcholine.
In chemistry, an organic compound is generally any chemical compound that contains carbon.
Ovulation is the release of eggs from the ovaries.
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
Plasma protein binding refers to the degree to which medications attach to proteins within the blood.
Portugal, officially the Portuguese Republic (República Portuguesa),In recognized minority languages of Portugal: Portugal is the oldest state in the Iberian Peninsula and one of the oldest in Europe, its territory having been continuously settled, invaded and fought over since prehistoric times.
Menopausal hormone therapy (MHT), or postmenopausal hormone therapy (PHT, PMHT), also known as hormone replacement therapy in menopause, is a form of hormone replacement therapy (HRT) which is used in postmenopausal, perimenopausal, and surgically menopausal women.
Premenstrual syndrome (PMS) refers to physical and emotional symptoms that occur in the one to two weeks before a woman's period.
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
Progesterone is a medication and naturally occurring steroid hormone.
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.
A progestin is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.
Progestogens, also sometimes spelled progestagens or gestagens, are a class of steroid hormones that bind to and activate the progesterone receptor (PR).
A radioligand is a radioactive biochemical substance (in particular, a ligand that is radiolabeled) that is used for diagnosis or for research-oriented study of the receptor systems of the body.
Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.
Roussel Uclaf S.A. was a French pharmaceutical company and one of several predecessor companies of today's Sanofi.
Scientific method is an empirical method of knowledge acquisition, which has characterized the development of natural science since at least the 17th century, involving careful observation, which includes rigorous skepticism about what one observes, given that cognitive assumptions about how the world works influence how one interprets a percept; formulating hypotheses, via induction, based on such observations; experimental testing and measurement of deductions drawn from the hypotheses; and refinement (or elimination) of the hypotheses based on the experimental findings.
Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood.
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen.
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
In chemistry, stereoselectivity is the property of a chemical reaction in which a single reactant forms an unequal mixture of stereoisomers during the non-stereospecific creation of a new stereocenter or during the non-stereospecific transformation of a pre-existing one.
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
The sulfate or sulphate (see spelling differences) ion is a polyatomic anion with the empirical formula.
Trademark distinctiveness is an important concept in the law governing trademarks and service marks.
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene.
Trimegestone, sold under the brand names Ondeva and Totelle among others, is a progestin medication which is used in menopausal hormone therapy and in the prevention of postmenopausal osteoporosis.
Tunisia (تونس; Berber: Tunes, ⵜⵓⵏⴻⵙ; Tunisie), officially the Republic of Tunisia, (الجمهورية التونسية) is a sovereign state in Northwest Africa, covering. Its northernmost point, Cape Angela, is the northernmost point on the African continent. It is bordered by Algeria to the west and southwest, Libya to the southeast, and the Mediterranean Sea to the north and east. Tunisia's population was estimated to be just under 11.93 million in 2016. Tunisia's name is derived from its capital city, Tunis, which is located on its northeast coast. Geographically, Tunisia contains the eastern end of the Atlas Mountains, and the northern reaches of the Sahara desert. Much of the rest of the country's land is fertile soil. Its of coastline include the African conjunction of the western and eastern parts of the Mediterranean Basin and, by means of the Sicilian Strait and Sardinian Channel, feature the African mainland's second and third nearest points to Europe after Gibraltar. Tunisia is a unitary semi-presidential representative democratic republic. It is considered to be the only full democracy in the Arab World. It has a high human development index. It has an association agreement with the European Union; is a member of La Francophonie, the Union for the Mediterranean, the Arab Maghreb Union, the Arab League, the OIC, the Greater Arab Free Trade Area, the Community of Sahel-Saharan States, the African Union, the Non-Aligned Movement, the Group of 77; and has obtained the status of major non-NATO ally of the United States. In addition, Tunisia is also a member state of the United Nations and a state party to the Rome Statute of the International Criminal Court. Close relations with Europe in particular with France and with Italy have been forged through economic cooperation, privatisation and industrial modernization. In ancient times, Tunisia was primarily inhabited by Berbers. Phoenician immigration began in the 12th century BC; these immigrants founded Carthage. A major mercantile power and a military rival of the Roman Republic, Carthage was defeated by the Romans in 146 BC. The Romans, who would occupy Tunisia for most of the next eight hundred years, introduced Christianity and left architectural legacies like the El Djem amphitheater. After several attempts starting in 647, the Muslims conquered the whole of Tunisia by 697, followed by the Ottoman Empire between 1534 and 1574. The Ottomans held sway for over three hundred years. The French colonization of Tunisia occurred in 1881. Tunisia gained independence with Habib Bourguiba and declared the Tunisian Republic in 1957. In 2011, the Tunisian Revolution resulted in the overthrow of President Zine El Abidine Ben Ali, followed by parliamentary elections. The country voted for parliament again on 26 October 2014, and for President on 23 November 2014.
Urine is a liquid by-product of metabolism in humans and in many animals.
11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone (INN), deoxycortone, and cortexone, is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
17α-Methyl-19-norprogesterone (developmental code name H-3510), also known as 17α-methyl-19-norpregn-4-ene-3,20-dione, is a progestin which was never marketed.
17α-Methylprogesterone (17α-MP), or 17α-methylpregn-4-ene-3,20-dione, is a steroidal progestin related to progesterone that was synthesized and characterized in 1949 but was never marketed.
19-Norpregnane, also known as 13β-methyl-17β-ethylgonane, is a norsteroid and the 19-demethyl analogue of pregnane.
19-Norprogesterone, also known as 19-norpregn-4-ene-3,20-dione, is a steroidal progestin and close analogue of the sex hormone progesterone, lacking only the C19 methyl group of that molecule.