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Protomap (neuroscience)

Index Protomap (neuroscience)

The Protomap is a primordial molecular map of the functional areas of the mammalian cerebral cortex during early embryonic development, at a stage when neural stem cells are still the dominant cell type. [1]

13 relations: Cellular differentiation, Cerebral cortex, Cortical patterning, Embryogenesis, Gyrification, Neural stem cell, Neurogenesis, Pasko Rakic, Radial glial cell, Radial unit hypothesis, Stem cell, Thalamus, Ventricular zone.

Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Cerebral cortex

The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.

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Cortical patterning

Cortical patterning is a field of developmental neuroscience which aims to determine how the various functional areas of the cerebral cortex are generated, what size and shape they will be, and how their spatial pattern across the surface of the cortex is specified.

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Embryogenesis

Embryogenesis is the process by which the embryo forms and develops.

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Gyrification

Gyrification is the process of forming the characteristic folds of the cerebral cortex.

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Neural stem cell

Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic development.

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Neurogenesis

Neurogenesis is the process by which nervous system cells, known as neurons, are produced by neural stem cells (NSC)s, and it occurs in all species of animals except the porifera (sponges) and placozoans.

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Pasko Rakic

Pasko Rakic (Paško Rakić) is a Yugoslav-born American neuroscientist, who presently works in the Yale School of Medicine Department of Neuroscience in New Haven, Connecticut.

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Radial glial cell

Radial glial cells are bipolar-shaped cells that span the width of the cortex in the developing vertebrate central nervous system (CNS) and serve as primary progenitor cells capable of generating neurons, astrocytes, and oligodendrocytes.

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Radial unit hypothesis

The Radial Unit Hypothesis (RUH) is a conceptual theory of cerebral cortex development, first described by Pasko Rakic.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Thalamus

The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.

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Ventricular zone

In vertebrate organisms, the ventricular zone (VZ) is a transient embryonic layer of tissue containing neural stem cells, principally radial glial cells, of the central nervous system (CNS).

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References

[1] https://en.wikipedia.org/wiki/Protomap_(neuroscience)

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