65 relations: Acid, Agonist, Albert Hofmann, Alkaloid, Base (chemistry), Benzothiophene, Chemical synthesis, Convention on Psychotropic Substances, Cross-tolerance, Dephosphorylation, Dopamine, Drug, Entheogen, Functional selectivity, Headache, Hydrolysis, Hydroxy group, Indole, Ingestion, International Narcotics Control Board, Ion, Iron, Keller's reagent, Lysergic acid diethylamide, Mescaline, Methyl group, Mushroom, N,N-Dimethyltryptamine, Nausea, Nitrogen, O-4310, O-Acetylpsilocin, Oxygen, Partial agonist, Perspiration, Pharmacology, Phenols, Phospholipase A2, Phospholipase C, Phosphorylation, Prefrontal cortex, Psilocybe mexicana, Psilocybin, Psilocybin mushroom, Psychoactive drug, Pupil, Serotonergic psychedelic, Serotonin, Standard for the Uniform Scheduling of Medicines and Poisons, Substituted tryptamine, ..., Sulfur, Sympathetic nervous system, Synesthesia, Tachycardia, Thermoregulation, Thiol, TiHKAL, Tryptamine, 1-Methylpsilocin, 4-HO-MET, 4-HO-MiPT, 5-HT receptor, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor. Expand index (15 more) » « Shrink index
An acid is a molecule or ion capable of donating a hydron (proton or hydrogen ion H+), or, alternatively, capable of forming a covalent bond with an electron pair (a Lewis acid).
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss scientist known best for being the first person to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD).
Alkaloids are a class of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.
In chemistry, bases are substances that, in aqueous solution, release hydroxide (OH−) ions, are slippery to the touch, can taste bitter if an alkali, change the color of indicators (e.g., turn red litmus paper blue), react with acids to form salts, promote certain chemical reactions (base catalysis), accept protons from any proton donor, and/or contain completely or partially displaceable OH− ions.
Benzothiophene is an aromatic organic compound with a molecular formula C8H6S and an odor similar to naphthalene (mothballs).
Chemical synthesis is a purposeful execution of chemical reactions to obtain a product, or several products.
The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971.
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug.
Dephosphorylation is the removal of a phosphate (PO43−) group from an organic compound by hydrolysis.
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.
An entheogen is a class of psychoactive substances that induce any type of spiritual experience aimed at development.
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
Headache is the symptom of pain anywhere in the region of the head or neck.
Hydrolysis is a term used for both an electro-chemical process and a biological one.
A hydroxy or hydroxyl group is the entity with the formula OH.
Indole is an aromatic heterocyclic organic compound with formula C8H7N.
Ingestion is the consumption of a substance by an organism.
The International Narcotics Control Board (INCB) is the independent and quasi-judicial control organ for the implementation of the United Nations drug conventions.
An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).
Iron is a chemical element with symbol Fe (from ferrum) and atomic number 26.
Keller's reagent can refer to either of two different mixtures of acids.
Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.
Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.
A mushroom, or toadstool, is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source.
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
Nitrogen is a chemical element with symbol N and atomic number 7.
O-4310 (1-isopropyl-6-fluoro-psilocin) is a tryptamine derivative developed by Organix which acts as a serotonin receptor agonist.
O-Acetylpsilocin (also known as psilacetin, 4-acetoxy-DMT, or 4-AcO-DMT) is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
Oxygen is a chemical element with symbol O and atomic number 8.
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals.
Pharmacology is the branch of biology concerned with the study of drug action, where a drug can be broadly defined as any man-made, natural, or endogenous (from within body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharmacon is used as a term to encompass these endogenous and exogenous bioactive species).
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of a hydroxyl group (—OH) bonded directly to an aromatic hydrocarbon group.
Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
Psilocybe mexicana is a psychedelic mushroom.
Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms.
A psilocybin mushroom is one of a polyphyletic group of fungi that contain any of various psychedelic compounds, including psilocybin, psilocin, and baeocystin.
A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.
The pupil is a hole located in the center of the iris of the eye that allows light to strike the retina.
Serotonergic psychedelics (also known as serotonergic hallucinogens) are a subclass of psychedelic drugs with a method of action strongly tied to the neurotransmitter serotonin.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
The Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) is an Australian legislative instrument produced by the Therapeutic Goods Administration (TGA).
Substituted tryptamines, or serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself.
Sulfur or sulphur is a chemical element with symbol S and atomic number 16.
The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the parasympathetic nervous system.
Synesthesia is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway.
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.
Thiol is an organosulfur compound that contains a carbon-bonded sulfhydryl (R–SH) group (where R represents an alkyl or other organic substituent).
TIHKAL: The Continuation is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines.
Tryptamine is a monoamine alkaloid.
1-Methylpsilocin is a tryptamine derivative which acts as a selective agonist for the 5-HT2C receptor (IC50 of 12 nM, vs 633 nM at 5-HT2A), and an inverse agonist at 5-HT2B (Ki of 38 nM).
4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, metocin, or methylcybin), is a lesser-known psychedelic drug.
4-HO-MiPT (miprocin, 4-hydroxy-N-methyl-N-isopropyltryptamine) is a synthetic substituted aromatic compound and a lesser-known psychedelic tryptamine.
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).