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Psilocin

Index Psilocin

Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. [1]

Table of Contents

  1. 67 relations: Acid, Acylation, Agonist, Albert Hofmann, Alkaloid, Base (chemistry), Benzothiophene, Chemical synthesis, Convention on Psychotropic Substances, Cross-tolerance, Dephosphorylation, Diário Oficial da União, Dimethylamine, Dopamine, Entheogen, Euphoria, Friedel–Crafts reaction, Functional selectivity, Headache, Homologous series, Hydrolysis, Hydroxy group, Indole, International Narcotics Control Board, Ion, Iron, LSD, Mescaline, Methyl group, Mushroom, N,N-Dimethyltryptamine, Nausea, Nitrogen, Norepinephrine, O-4310, O-Acetylpsilocin, Oxygen, Partial agonist, Phenols, Phospholipase A2, Phospholipase C, Phosphorylation, Prefrontal cortex, Psilocybe mexicana, Psilocybin, Psilocybin mushroom, Psychedelic drug, Psychoactive drug, Serotonin, Standard for the Uniform Scheduling of Medicines and Poisons, ... Expand index (17 more) »

  2. Hydroxyarenes
  3. Psilocybin
  4. Psychedelic drugs

Acid

An acid is a molecule or ion capable of either donating a proton (i.e. hydrogen ion, H+), known as a Brønsted–Lowry acid, or forming a covalent bond with an electron pair, known as a Lewis acid.

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Acylation

In chemistry, acylation is a broad class of chemical reactions in which an acyl group is added to a substrate.

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Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

See Psilocin and Agonist

Albert Hofmann

Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD).

See Psilocin and Albert Hofmann

Alkaloid

Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom.

See Psilocin and Alkaloid

Base (chemistry)

In chemistry, there are three definitions in common use of the word "base": Arrhenius bases, Brønsted bases, and Lewis bases.

See Psilocin and Base (chemistry)

Benzothiophene

Benzothiophene is an aromatic organic compound with a molecular formula C8H6S and an odor similar to naphthalene (mothballs).

See Psilocin and Benzothiophene

Chemical synthesis

Chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products.

See Psilocin and Chemical synthesis

Convention on Psychotropic Substances

The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971.

See Psilocin and Convention on Psychotropic Substances

Cross-tolerance

Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug.

See Psilocin and Cross-tolerance

Dephosphorylation

In biochemistry, dephosphorylation is the removal of a phosphate () group from an organic compound by hydrolysis.

See Psilocin and Dephosphorylation

Diário Oficial da União

The Diário Oficial da União (literally Official Diary of the Union), abbreviated DOU, is the official journal of the federal government of Brazil.

See Psilocin and Diário Oficial da União

Dimethylamine

Dimethylamine is an organic compound with the formula (CH3)2NH.

See Psilocin and Dimethylamine

Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.

See Psilocin and Dopamine

Entheogen

Entheogens are psychoactive substances, including psychedelic drugs, such as magic mushrooms and magic plants used in sacred contexts in religion for inducing spiritual development throughout history. Psilocin and Entheogen are Entheogens.

See Psilocin and Entheogen

Euphoria

Euphoria is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness.

See Psilocin and Euphoria

Friedel–Crafts reaction

The Friedel–Crafts reactions are a set of reactions developed by Charles Friedel and James Crafts in 1877 to attach substituents to an aromatic ring.

See Psilocin and Friedel–Crafts reaction

Functional selectivity

Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signaling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.

See Psilocin and Functional selectivity

Headache

Headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck.

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Homologous series

In organic chemistry, a homologous series is a sequence of compounds with the same functional group and similar chemical properties in which the members of the series differ by the number of repeating units they contain.

See Psilocin and Homologous series

Hydrolysis

Hydrolysis is any chemical reaction in which a molecule of water breaks one or more chemical bonds.

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Hydroxy group

In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom.

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Indole

Indole is an organic compound with the formula.

See Psilocin and Indole

International Narcotics Control Board

The International Narcotics Control Board (INCB) is an independent treaty body, one of the four treaty-mandated bodies under international drug control law (alongside the Commission on Narcotic Drugs, UNODC on behalf of the Secretary-General, and the WHO).

See Psilocin and International Narcotics Control Board

Ion

An ion is an atom or molecule with a net electrical charge.

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Iron

Iron is a chemical element.

See Psilocin and Iron

LSD

Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäure-diethylamid), and known colloquially as acid or lucy, is a potent psychedelic drug. Psilocin and LSD are Entheogens and serotonin receptor agonists.

See Psilocin and LSD

Mescaline

Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Psilocin and mescaline are Entheogens and serotonin receptor agonists.

See Psilocin and Mescaline

Methyl group

In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula). In formulas, the group is often abbreviated as Me.

See Psilocin and Methyl group

Mushroom

A mushroom or toadstool is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground, on soil, or on its food source.

See Psilocin and Mushroom

N,N-Dimethyltryptamine

N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. Psilocin and n,N-Dimethyltryptamine are Dimethylamino compounds, Entheogens, psychedelic tryptamines, serotonin receptor agonists and tryptamine alkaloids.

See Psilocin and N,N-Dimethyltryptamine

Nausea

Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit.

See Psilocin and Nausea

Nitrogen

Nitrogen is a chemical element; it has symbol N and atomic number 7.

See Psilocin and Nitrogen

Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator.

See Psilocin and Norepinephrine

O-4310

O-4310 (1-isopropyl-6-fluoro-psilocin) is a tryptamine derivative developed by Organix Inc which acts as a serotonin receptor agonist. Psilocin and o-4310 are Dimethylamino compounds.

See Psilocin and O-4310

O-Acetylpsilocin

O-Acetylpsilocin (also known as psilacetin, 4-acetoxy-DMT, 4-AcO-DMT, or synthetic shrooms) is a semi-synthetic psychoactive drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin. Psilocin and o-Acetylpsilocin are Dimethylamino compounds, Entheogens, Mycotoxins, psychedelic tryptamines, serotonin receptor agonists and tryptamine alkaloids.

See Psilocin and O-Acetylpsilocin

Oxygen

Oxygen is a chemical element; it has symbol O and atomic number 8.

See Psilocin and Oxygen

Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

See Psilocin and Partial agonist

Phenols

In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (−O H) bonded directly to an aromatic hydrocarbon group. Psilocin and phenols are Hydroxyarenes.

See Psilocin and Phenols

Phospholipase A2

The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule: This particular phospholipase specifically recognizes the sn2 acyl bond of phospholipids and catalytically hydrolyzes the bond, releasing arachidonic acid and lysophosphatidyl choline, a precursor of lysophosphatidic acid.

See Psilocin and Phospholipase A2

Phospholipase C

Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).

See Psilocin and Phospholipase C

Phosphorylation

In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion.

See Psilocin and Phosphorylation

Prefrontal cortex

In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex.

See Psilocin and Prefrontal cortex

Psilocybe mexicana

Psilocybe mexicana is a psychedelic mushroom. Psilocin and Psilocybe mexicana are Entheogens.

See Psilocin and Psilocybe mexicana

Psilocybin

Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. Psilocin and Psilocybin are Entheogens, psychedelic drugs, psychedelic tryptamines, serotonin receptor agonists and tryptamine alkaloids.

See Psilocin and Psilocybin

Psilocybin mushroom

Psilocybin mushrooms, commonly known as magic mushrooms or shrooms, are a polyphyletic informal group of fungi that contain psilocybin, which turns into psilocin upon ingestion. Psilocin and psilocybin mushroom are Entheogens and psilocybin.

See Psilocin and Psilocybin mushroom

Psychedelic drug

Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Psilocin and psychedelic drug are psychedelic drugs.

See Psilocin and Psychedelic drug

Psychoactive drug

A psychoactive drug, mind-altering drug, or consciousness-altering drug is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.

See Psilocin and Psychoactive drug

Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Psilocin and Serotonin are Hydroxyarenes and tryptamine alkaloids.

See Psilocin and Serotonin

Standard for the Uniform Scheduling of Medicines and Poisons

The Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP), also known as the Poisons Standard for short, is an Australian legislative instrument produced by the Therapeutic Goods Administration (TGA).

See Psilocin and Standard for the Uniform Scheduling of Medicines and Poisons

Substituted tryptamine

Substituted tryptamines, or serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself.

See Psilocin and Substituted tryptamine

Sulfur

Sulfur (also spelled sulphur in British English) is a chemical element; it has symbol S and atomic number 16.

See Psilocin and Sulfur

Sympathetic nervous system

The sympathetic nervous system (SNS) is one of the three divisions of the autonomic nervous system, the others being the parasympathetic nervous system and the enteric nervous system.

See Psilocin and Sympathetic nervous system

Synesthesia

Synesthesia (American English) or synaesthesia (British English) is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to involuntary experiences in a second sensory or cognitive pathway.

See Psilocin and Synesthesia

Tachycardia

Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.

See Psilocin and Tachycardia

Thermoregulation

Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.

See Psilocin and Thermoregulation

Thiol

In organic chemistry, a thiol, or thiol derivative, is any organosulfur compound of the form, where R represents an alkyl or other organic substituent.

See Psilocin and Thiol

TiHKAL

TIHKAL: The Continuation is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. Psilocin and TiHKAL are psychedelic tryptamines.

See Psilocin and TiHKAL

Tryptamine

Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. Psilocin and Tryptamine are serotonin receptor agonists.

See Psilocin and Tryptamine

1-Methylpsilocin

1-Methylpsilocin is a tryptamine derivative which acts as a selective agonist for the 5-HT2C receptor (IC50 of 12 nM, vs 633 nM at 5-HT2A), and an inverse agonist at 5-HT2B (Ki of 38 nM). Psilocin and 1-Methylpsilocin are Dimethylamino compounds, Hydroxyarenes and serotonin receptor agonists.

See Psilocin and 1-Methylpsilocin

4-AcO-MET

4-acetoxy-MET (4-acetoxy-N-methyl-N-ethyltryptamine), also known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine. Psilocin and 4-AcO-MET are psychedelic tryptamines.

See Psilocin and 4-AcO-MET

4-HO-MET

4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, metocin, or methylcybin) is a lesser-known psychedelic drug. Psilocin and 4-HO-MET are psychedelic tryptamines.

See Psilocin and 4-HO-MET

4-HO-MiPT

4-HO-MiPT (miprocin, 4-hydroxy-N-methyl-N-isopropyltryptamine) is a synthetic substituted aromatic compound and a lesser-known psychedelic tryptamine. Psilocin and 4-HO-MiPT are Entheogens, psychedelic tryptamines and serotonin receptor agonists.

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5-HT receptor

5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter.

See Psilocin and 5-HT1A receptor

5-HT2A receptor

The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

See Psilocin and 5-HT2A receptor

5-HT2C receptor

The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

See Psilocin and 5-HT2C receptor

See also

Hydroxyarenes

Psilocybin

Psychedelic drugs

References

[1] https://en.wikipedia.org/wiki/Psilocin

Also known as 4-HO-DMT, 4-hydroxy-N,N-dimethyltryptamine, Psilocine, Psilocyn, Psilotsin, Psylocin.

, Substituted tryptamine, Sulfur, Sympathetic nervous system, Synesthesia, Tachycardia, Thermoregulation, Thiol, TiHKAL, Tryptamine, 1-Methylpsilocin, 4-AcO-MET, 4-HO-MET, 4-HO-MiPT, 5-HT receptor, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor.