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74 relations: AMPA receptor, Aspartic acid, Ataxia telangiectasia and Rad3 related, ATM serine/threonine kinase, Bruton's tyrosine kinase, Calorie restriction, Cancer, Cell (journal), Class I PI 3-kinases, Class II PI 3-kinases, Class III PI 3-kinase, Diabetes mellitus, DLG4, Enzyme, Epidermal growth factor receptor, FYVE domain, G protein–coupled receptor, GSK3B, Hepatocyte, Human Genome Organisation, Hydroxy group, Icos, Inositol, Insulin, Insulin receptor substrate, Insulin signal transduction pathway, Insulin-like growth factor 1, Lewis C. Cantley, Long-term potentiation, LY294002, MTOR, NMDA receptor, OGT (gene), Oncogene, P110α, P110δ, P70-S6 Kinase 1, Phagocytosis, Phosphatidylinositol, Phosphatidylinositol (3,4,5)-trisphosphate, Phosphatidylinositol 3,4-bisphosphate, Phosphatidylinositol 3,5-bisphosphate, Phosphatidylinositol 3-phosphate, Phosphatidylinositol-4,5-bisphosphate 3-kinase, Phosphatidylinositol-4-phosphate 3-kinase, Phosphoinositide 3-kinase, Phosphoinositide 3-kinase inhibitor, Phosphoinositide-dependent kinase-1, PI3K/AKT/mTOR pathway, PIK3C2A, ..., PIK3C2B, PIK3C2G, PIK3C3, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R4, PIK3R5, Pleckstrin homology domain, Polyomaviridae, Protein dimer, Protein kinase B, Protein subunit, PTEN (gene), PX domain, Receptor tyrosine kinase, SH2 domain, SH3 domain, Signal transduction, Transformation (genetics), White blood cell, Wortmannin. Expand index (24 more) »
AMPA receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS).
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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Ataxia telangiectasia and Rad3 related
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene.
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ATM serine/threonine kinase
ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks.
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Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene.
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Calorie restriction
Calorie restriction, or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cell (journal)
Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences.
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Class I PI 3-kinases
Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation.
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Class II PI 3-kinases
Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
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Class III PI 3-kinase
Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
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Diabetes mellitus
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
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DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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FYVE domain
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and '''E'''EA1, in which it has been found.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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GSK3B
Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.
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Hepatocyte
A hepatocyte is a cell of the main parenchymal tissue of the liver.
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Human Genome Organisation
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome.
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Hydroxy group
A hydroxy or hydroxyl group is the entity with the formula OH.
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Icos
Icos Corporation (trademark ICOS) was an American biotechnology company and the largest biotechnology company in the U.S. state of Washington, before it was sold to Eli Lilly and Company in 2007.
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Inositol
Myo-inositol, or simply inositol, is a carbocyclic sugar that is abundant in brain and other mammalian tissues, mediates cell signal transduction in response to a variety of hormones, neurotransmitters and growth factors and participates in osmoregulation It is a sugar alcohol with half the sweetness of sucrose (table sugar).
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Insulin
Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.
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Insulin receptor substrate
Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.
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Insulin signal transduction pathway
The insulin transduction pathway is a biochemical pathway by which insulin increases the uptake of glucose into fat and muscle cells and reduces the synthesis of glucose in the liver and hence is involved in maintaining glucose homeostasis.
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Insulin-like growth factor 1
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.
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Lewis C. Cantley
Lewis C. Cantley (born February 20, 1949) is an American cell biologist and biochemist who has made significant advances to the understanding of cancer metabolism.
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Long-term potentiation
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity.
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LY294002
LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks).
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MTOR
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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OGT (gene)
UDP-N-acetylglucosamine—peptide N-acetylglucosaminyltransferase, also known as O-linked β-N-acetylglucosamine transferase and O-GlcNAc transferase, OGT is an enzyme that in humans is encoded by the OGT gene.
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Oncogene
An oncogene is a gene that has the potential to cause cancer.
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P110α
The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol.
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P110δ
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene.
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P70-S6 Kinase 1
Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene.
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Phagocytosis
In cell biology, phagocytosis is the process by which a cell—often a phagocyte or a protist—engulfs a solid particle to form an internal compartment known as a phagosome.
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Phosphatidylinositol
Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides.
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Phosphatidylinositol (3,4,5)-trisphosphate
Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2).
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Phosphatidylinositol 3,4-bisphosphate
Phosphatidylinositol (3,4)-bisphosphate (PtdIns(3,4)P2) is a minor phospholipid component of cell membranes, yet an important second messenger.
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Phosphatidylinositol 3,5-bisphosphate
Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is one of the seven phosphoinositides found in eukaryotic cell membranes.
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Phosphatidylinositol 3-phosphate
Phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes.
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Phosphatidylinositol-4,5-bisphosphate 3-kinase
In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
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Phosphatidylinositol-4-phosphate 3-kinase
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Phosphoinositide 3-kinase inhibitor
A phosphoinositide 3-kinase inhibitor (PI3K inhibitor) is a class of medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes, which are part of the PI3K/AKT/mTOR pathway, an important signalling pathway for many cellular functions such as growth control, metabolism and translation initiation.
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Phosphoinositide-dependent kinase-1
In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans.
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PI3K/AKT/mTOR pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.
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PIK3C2A
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene.
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PIK3C2B
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.
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PIK3C2G
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.
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PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme that in humans is encoded by the PIK3C3 gene.
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PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.
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PIK3CG
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.
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PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.
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PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.
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PIK3R3
Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.
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PIK3R4
Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.
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PIK3R5
Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.
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Pleckstrin homology domain
Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
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Polyomaviridae
Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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Protein subunit
In structural biology, a protein subunit is a single protein molecule that assembles (or "coassembles") with other protein molecules to form a protein complex.
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PTEN (gene)
Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene.
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PX domain
The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.
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Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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SH2 domain
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.
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SH3 domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Transformation (genetics)
In molecular biology, transformation is the genetic alteration of a cell resulting from the direct uptake and incorporation of exogenous genetic material from its surroundings through the cell membrane(s).
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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Wortmannin
Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks).
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Redirects here:
1-phosphatidylinositol 3-kinase, ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase, EC 2.7.1.137, PI 3 kinase, PI 3-kinase, PI-3 kinase, PI-3K, PI3 Kinase, PI3 kinase, PI3-K, PI3K, PIK3, Phosphatidyl-inositol-3-kinase, Phosphatidylinositol 3-kinase, Phosphoinositide 3-Kinase (PI3K), Phosphoinositide 3-kinases, Phosphoinositide-3, Phosphoinositide-3-kinase, Pi3kinase, PtdIns3K.
References
[1] https://en.wikipedia.org/wiki/Phosphoinositide_3-kinase
