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Pyrimidinylpiperazine

Index Pyrimidinylpiperazine

1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. [1]

39 relations: Alnespirone, Anxiolytic, Azapirone, Azaspirodecanedione, Benzothiazole, Benzylpiperazine, Binospirone, Buspirone, Chemical compound, Dasatinib, Derivative (chemistry), Diphenylmethylpiperazine, Dopamine receptor, Dopamine receptor D2, Dopamine receptor D3, Dopamine receptor D4, Drug, Enilospirone, Eptapirone, Gepirone, Intrinsic activity, Ipsapirone, Ligand (biochemistry), Metabolite, Partial agonist, Perospirone, Phenylpiperazine, Piperazine, Piribedil, Pyridinylpiperazine, Receptor antagonist, Revospirone, Substituted piperazine, Tandospirone, Tiospirone, Tirilazad, Umespirone, Zalospirone, 5-HT1A receptor.

Alnespirone

Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class.

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Anxiolytic

An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.

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Azapirone

Azapirones are a class of drugs used as anxiolytics, antidepressants, and antipsychotics.

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Azaspirodecanedione

Azaspirodecanedione is a chemical compound.

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Benzothiazole

Benzothiazole is an aromatic heterocyclic compound with the chemical formula.

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Benzylpiperazine

Benzylpiperazine (BZP) is a recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity and seizures. No deaths have been reported following a sole ingestion of BZP, although there have been at least two deaths from the combination of BZP and MDMA. Its sale is banned in several countries, including Australia, Canada, New Zealand, the United States, the Republic of Ireland, the United Kingdom, Bulgaria, Romania and other parts of Europe.

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Binospirone

Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT1A receptors.

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Buspirone

Buspirone, sold under the brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder (GAD).

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Chemical compound

A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) composed of atoms from more than one element held together by chemical bonds.

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Dasatinib

Dasatinib, sold under the brand name Sprycel, is a chemotherapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL).

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Derivative (chemistry)

In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.

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Diphenylmethylpiperazine

1-(Diphenylmethyl)piperazine, also known as benzhydrylpiperazine, is a chemical compound and piperazine derivative.

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Dopamine receptor

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).

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Dopamine receptor D2

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.

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Dopamine receptor D3

Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.

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Dopamine receptor D4

The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.

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Drug

A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.

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Enilospirone

Enilospirone (CERM-3,726) is a selective 5-HT1A receptor agonist of the azapirone class.

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Eptapirone

Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family.

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Gepirone

Gepirone is an antidepressant and anxiolytic drug of the azapirone group that was synthesized by Bristol-Myers Squibb in 1986 and has been under development for the treatment of depression but has yet to be marketed.

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Intrinsic activity

Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.

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Ipsapirone

Ipsapirone is a selective 5-HT1A receptor partial agonist of the piperazine and azapirone chemical classes.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Metabolite

A metabolite is the intermediate end product of metabolism.

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Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

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Perospirone

Perospirone (Lullan) is an atypical antipsychotic of the azapirone family.

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Phenylpiperazine

1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring.

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Piperazine

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.

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Piribedil

Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist.

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Pyridinylpiperazine

1-(2-Pyridinyl)piperazine is a chemical compound and piperazine derivative.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Revospirone

Revospirone (Bay Vq 7813) is an azapirone drug which was patented as a veterinary tranquilizer but was never marketed.

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Substituted piperazine

Substituted piperazines are a class of chemical compounds.

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Tandospirone

Tandospirone (brand name Sediel) is an anxiolytic and antidepressant drug used in China and Japan, where it is marketed by Dainippon Sumitomo Pharma.

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Tiospirone

Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class.

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Tirilazad

Tirilazad is a drug that has been proposed to treat acute ischaemic stroke.

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Umespirone

Umespirone (KC-9172) is a drug of the azapirone class which possesses anxiolytic and antipsychotic properties.

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Zalospirone

Zalospirone (WY-47,846) is a selective 5-HT1A partial agonist of the azapirone chemical class.

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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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Redirects here:

1-(2-Pyrimidinyl)-piperazine, 1-(2-Pyrimidinyl)piperazine, 1-(2-pyrimidinyl)-piperazine, 1-(2-pyrimidinyl)piperazine, 1-PP, 2-Pyrimidinyl)-1-piperazine, 2-Pyrimidinyl-1-piperazine, 2-Pyrimidinylpiperazine, 2-pyrimidinyl-1-piperazine, 2-pyrimidinylpiperazine, Pyrimidinyl-piperazine.

References

[1] https://en.wikipedia.org/wiki/Pyrimidinylpiperazine

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