5 relations: Biosynthesis, Sepiapterin reductase, Tetrahydrobiopterin, 6-pyruvoyltetrahydropterin 2'-reductase, 6-Pyruvoyltetrahydropterin synthase.
Biosynthesis
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
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Sepiapterin reductase
Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene.
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Tetrahydrobiopterin
Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.
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6-pyruvoyltetrahydropterin 2'-reductase
In enzymology, a 6-pyruvoyltetrahydropterin 2'-reductase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are 6-lactoyl-5,6,7,8-tetrahydropterin and NADP+, whereas its 3 products are 6-pyruvoyltetrahydropterin, NADPH, and H+.
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6-Pyruvoyltetrahydropterin synthase
In enzymology, a 6-pyruvoyltetrahydropterin synthase (PTPS) is an enzyme that catalyzes the following chemical reaction: 7,8-Dihydroneopterin triphosphate \rightleftharpoons 6-pyruvoyltetrahydropterin + triphosphate This reaction is the second step (shown above) in the biosynthesis of Tetrahydrobiopterin from GTP, which is used as a cofactor in the synthesis of Aromatic amino acid Monooxygenases and Nitric oxide synthase PTPS converts 7,8-Dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin (PTP) through the loss of the triphosphate group, a stereospecific reduction of the double bond between the top right nitrogen and carbon in the ring on the ightht, The oxidation of the hydroxyl groups located on the first and second carbons of the side chain, and an internal base-catalyzed hydrogen tnsfer. 6-pyruvoyltetrahydropterin synthase (PTPS) can be found in the cytoplasm as well as the nucleus of cells according to immunohistochemical studies conducted.
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6-PTHB, 6-Pyruvoyltetrahydropterin, 6-pyruvoyl-5,6,7,8-tetrahydropterin, 6-pyruvoyltetrahydropterin, PTHB, Pyruvoyltetrahydropterin.