182 relations: Active metabolite, Adrenergic antagonist, Agranulocytosis, Alpha blocker, Alpha-1 adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-2 adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor, Alzheimer's disease, Anaphylaxis, Anticholinergic, Antihistamine, Antipsychotic, Anxiety, Anxiety disorder, Aripiprazole, Asenapine, AstraZeneca, Atypical antipsychotic, Autoreceptor, Beagle, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Biovail, Bipolar disorder, Bipolar I disorder, Bloomberg L.P., British National Formulary, Bupropion, Cardiac arrest, Cardiomyopathy, Cataract, Chlorpromazine, Clozapine, Cognition, Complete blood count, Constipation, Death of Dan Markingson, Dementia, Diabetes mellitus, Diabetic ketoacidosis, Dibenzothiazepine, Dopamine antagonist, Dopamine receptor, Dopamine receptor D1, Dopamine receptor D2, Dopamine receptor D3, ..., Dopamine receptor D4, Dopamine receptor D5, Dyskinesia, Dysphagia, Edema, Electrocardiography, Eosinophilia, Epileptic seizure, Extrapyramidal symptoms, Fluphenazine, Food and Drug Administration, Gabapentin, Galactorrhea, Gynecomastia, Haloperidol, Health Canada, Hepatitis, Histamine H1 receptor, Histamine H2 receptor, Histamine H3 receptor, Histamine H4 receptor, Histamine receptor, Hypercholesterolemia, Hyperglycemia, Hypertension, Hyponatremia, Hypotension, Hypothyroidism, Ibuprofen brand names, Indigestion, Insomnia, Irregular menstruation, Jaundice, Kidney, Lactam, Lamotrigine, Leukopenia, Ligand (biochemistry), Lithium (medication), Liver, Loxapine, Lurasidone, Major depressive disorder, Mania, Mean absolute difference, Medicines and Healthcare products Regulatory Agency, MedlinePlus, Modified-release dosage, Molindone, Movement disorders, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Muscarinic antagonist, Musical hallucinations, Myocarditis, National Health Service, Neuroleptic malignant syndrome, Neutropenia, New Drug Application, Nigrostriatal pathway, NMDA receptor, Nucleophilic substitution, Off-label use, Olanzapine, Oral administration, Orthostatic hypotension, Paliperidone, Pancreatitis, Parkinson's disease, Partial agonist, Perphenazine, Perspiration, Pharmaceutical Benefits Scheme, Pharmacodynamics, Pharyngitis, Phosphoryl chloride, Pimozide, Positive and Negative Syndrome Scale, Pregnancy, Priapism, Prolactin, QT interval, Relative risk, Restless legs syndrome, Risperidone, Schizophrenia, Seizure threshold, Serotonin receptor antagonist, Sertindole, Sigma-1 receptor, Sigma-2 receptor, Somnolence, Stevens–Johnson syndrome, Suicidal ideation, Syncope (medicine), Systematic review, Tachycardia, Tardive dyskinesia, Tetracyclic, The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, The Local, The Madison / St. Clair Record, Thioridazine, Tiotixene, Tourette syndrome, Trifluoperazine, Tuberoinfundibular pathway, Typical antipsychotic, Valproate, Vomiting, Weakness, Xerostomia, Ziprasidone, Zotepine, 5-HT receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT1F receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT4 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor. Expand index (132 more) » « Shrink index
An active metabolite is an active form of a drug after it has been processed by the body.
An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors.
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils causing a neutropenia in the circulating blood.
Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor.
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.
Antihistamines are drugs which treat allergic rhinitis and other allergies.
Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.
Anxiety disorders are a group of mental disorders characterized by significant feelings of anxiety and fear.
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.
Asenapine, sold under the trade names Saphris and Sycrest among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder.
AstraZeneca plc is an Anglo–Swedish multinational pharmaceutical and biopharmaceutical company.
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.
The beagle is a breed of small hound that is similar in appearance to the much larger foxhound.
The beta-1 adrenergic receptor (β1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation.
Biovail Corporation was a Canadian pharmaceutical company, operating internationally in all aspects of pharmaceutical products.
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features.
Bloomberg L.P. is a privately held financial, software, data, and media company headquartered in Midtown Manhattan, New York City.
The British National Formulary (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS).
Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used as an antidepressant and smoking cessation aid.
Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively pump.
Cardiomyopathy is a group of diseases that affect the heart muscle.
A cataract is a clouding of the lens in the eye which leads to a decrease in vision.
Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication.
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.
Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".
A complete blood count (CBC), also known as a complete blood cell count, full blood count (FBC), or full blood exam (FBE), is a blood panel requested by a doctor or other medical professional that gives information about the cells in a patient's blood, such as the cell count for each cell type and the concentrations of various proteins and minerals.
Constipation refers to bowel movements that are infrequent or hard to pass.
Dan Markingson (November 25, 1976 – May 8, 2004) was a young man from St.
Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus.
Dibenzothiazepines are chemical compounds which are derivatives of thiazepine with two benzene rings.
A dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism.
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.
Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.
Dyskinesia refers to a category of movement disorders that are characterized by involuntary muscle movements, including movements similar to tics or chorea and diminished voluntary movements.
Dysphagia is the medical term for the symptom of difficulty in swallowing.
Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.
Electrocardiography (ECG or EKG) is the process of recording the electrical activity of the heart over a period of time using electrodes placed on the skin.
Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds.
An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.
Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE), are drug-induced movement disorders that include acute and tardive symptoms.
Fluphenazine, sold under the brand names Prolixin among others, is an antipsychotic medication.
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
Gabapentin, sold under the brand name Neurontin among others, is a medication which is used to treat epilepsy (specifically partial seizures), neuropathic pain, hot flashes, and restless legs syndrome.
Galactorrhea (also spelled galactorrhoea) (galacto- + -rrhea) or lactorrhea (lacto- + -rrhea) is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.
Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication.
Health Canada (Santé Canada) is the department of the government of Canada with responsibility for national public health.
Hepatitis is inflammation of the liver tissue.
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
H2 receptors are positively coupled to adenylate cyclase via Gs.
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.
The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily.
The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood.
Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia) is a condition in which an excessive amount of glucose circulates in the blood plasma.
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
Hyponatremia is a low sodium level in the blood.
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone.
The analgesic and non-steroidal anti-inflammatory drug (NSAID) ibuprofen is sold under a wide variety of brand names across the world; the most common being its first registered trademark name of Brufen, along with Advil, Motrin, and Nurofen.
Indigestion, also known as dyspepsia, is a condition of impaired digestion.
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
Irregular menstruation is a menstrual disorder whose manifestations include irregular cycle lengths as well as metrorrhagia (vaginal bleeding between expected periods).
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and whites of the eyes due to high bilirubin levels.
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
A lactam is a cyclic amide.
Lamotrigine, sold as the brand name Lamictal among others, is an anticonvulsant medication used to treat epilepsy and bipolar disorder.
Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
Lithium compounds, also known as lithium salts, are primarily used as a psychiatric medication.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
Loxapine (several trade names worldwide) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia.
Lurasidone (trade name Latuda) is an atypical antipsychotic developed by Dainippon Sumitomo Pharma and marketed by Sunovion in the U.S. It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013.
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability can be more pronounced and result in violence, or anxiety.
The mean absolute difference (univariate) is a measure of statistical dispersion equal to the average absolute difference of two independent values drawn from a probability distribution.
The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department of Health and Social Care in the United Kingdom which is responsible for ensuring that medicines and medical devices work and are acceptably safe.
MedlinePlus is an online information service produced by the United States National Library of Medicine.
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release dosage) or to a specific target in the body (targeted-release dosage).
Molindone, sold under the brand name Moban, is an antipsychotic which is used in the United States in the treatment of schizophrenia.
Movement disorders are clinical syndromes with either an excess of movement or a paucity of voluntary and involuntary movements, unrelated to weakness or spasticity.
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor.
Musical hallucinations fall under the category of auditory hallucinations and describe a disorder in which a sound is perceived as instrumental music, sounds, or songs.
Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle.
The National Health Service (NHS) is the name used for each of the public health services in the United Kingdom – the National Health Service in England, NHS Scotland, NHS Wales, and Health and Social Care in Northern Ireland – as well as a term to describe them collectively.
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that occasionally occurs in response to neuroleptic or antipsychotic medication.
Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.
The Food and Drug Administration's New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.
The nigrostriatal pathway or the nigrostriatal bundle (NSB), is a dopaminergic pathway that connects the substantia nigra pars compacta (SNc) with the dorsal striatum (i.e., the caudate nucleus and putamen).
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
In organic and inorganic chemistry, nucleophilic substitution is a fundamental class of reactions in which an electron rich nucleophile selectively bonds with or attacks the positive or partially positive charge of an atom or a group of atoms to replace a leaving group; the positive or partially positive atom is referred to as an electrophile.
Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.
Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.
Paliperidone, sold under the trade name Invega among others, is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications.
Pancreatitis is inflammation of the pancreas.
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
Perphenazine is a typical antipsychotic drug.
Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals.
The Pharmaceutical Benefits Scheme (PBS) is a program of the Australian Government that provides subsidised prescription drugs to residents of Australia, as well as certain foreign visitors covered by a Reciprocal Health Care Agreement.
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
Pharyngitis is inflammation of the back of the throat, known as the pharynx.
Phosphoryl chloride (commonly called phosphorus oxychloride) is a colourless liquid with the formula 3.
Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class.
The Positive and Negative Syndrome Scale (PANSS) is a medical scale used for measuring symptom severity of patients with schizophrenia.
Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.
Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after stimulation has ended.
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.
In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
In statistics and epidemiology, relative risk or risk ratio (RR) is the ratio of the probability of an event occurring (for example, developing a disease, being injured) in an exposed group to the probability of the event occurring in a comparison, non-exposed group.
Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one's legs.
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
The term seizure threshold is used to describe the balance between excitatory and inhibitory forces in the brain which affect how susceptible a person is to seizures.
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action at serotonin (5-HT) receptors.
Sertindole (brand names: Serdolect and Serlect) is an antipsychotic medication.
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.
The sigma-2 receptor (σ2R) is a sigma receptor subtype that has been found highly expressed in malignant cancer cells, and is currently under investigation for its potential diagnostic and therapeutic uses.
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction.
Suicidal ideation, also known as suicidal thoughts, is thinking about or having an unusual preoccupation with suicide.
Syncope, also known as fainting, is a loss of consciousness and muscle strength characterized by a fast onset, short duration, and spontaneous recovery.
Systematic reviews are a type of literature review that uses systematic methods to collect secondary data, critically appraise research studies, and synthesize studies.
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
Tardive dyskinesia (TD) is a disorder that results in involuntary, repetitive body movements.
Tetracyclics are chemical compounds that contain four interconnected rings of atoms.
The GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) is a method of assessing the certainty in evidence (also known as quality of evidence or confidence in effect estimates) and the strength of recommendations in health care.
The Local is an English-language digital news publisher with local editions in Sweden, Germany, France, Spain, Switzerland, Norway, Denmark, Austria and Italy.
The Madison / St.
Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.
Tiotixene, or thiothixene, sold under the brand name Navane among others, is a typical antipsychotic of the thioxanthene class which is related to chlorprothixene and is used in the treatment of psychoses like schizophrenia and bipolar mania.
Tourette syndrome (TS or simply Tourette's) is a common neuropsychiatric disorder with onset in childhood, characterized by multiple motor tics and at least one vocal (phonic) tic.
Trifluoperazine, sold under a number of brand names, is a typical antipsychotic primarily used to treat schizophrenia.
The tuberoinfundibular pathway refers to a population of dopamine neurons that project from the arcuate nucleus (the "infundibular nucleus") in the tuberal region of the hypothalamus to the median eminence.
Typical antipsychotics are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).
Valproate (VPA), and its valproic acid, sodium valproate, and valproate semisodium forms, are medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.
Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.
Weakness or asthenia is a symptom of a number of different conditions.
Xerostomia, also known as dry mouth and dry mouth syndrome, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.
Zotepine (brand names: Losizopilon (JP), Lodopin (ID, JP), Setous (JP), Zoleptil (CZ, PT, TR, UK†); where † indicates a formulation that has been discontinued) is an atypical antipsychotic drug indicated for acute and chronic schizophrenia.
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.
5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.
5-hydroxytryptamine (serotonin) 1E receptor (5-HT1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family (Gi-coupled serotonin receptor).
5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.
5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.
ATC code N05AH04, ATCvet code QN05AH04, Asicot, C21H25N3O2S, Ketipinor, Quepin, Quetiapin hemifumarate, Quetiapina, Quetiapine fumarate, Quetiapinum, Quietipine, SEROQUEL XR, Sequase, Seraquel, Seroquel, Seroquel Prolong, Seroquel SR, Seroquel XR, Seroquel withdrawl, Seroquil, Snoozeberries, Special Q, Xeroquel.