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Index R7

R7 or R-7 may refer to. [1]

24 relations: AMD Radeon Rx 200 series, Aserca Airlines, ATC code R07, Chestnut Hill East Line, D7 motorway (Czech Republic), Grupo Record, Leica R4-R7, List of motorways in Belgium, List of R-phrases, R-7 (rocket family), R-7 Semyorka, R7 (drug), R7 (Rodalies de Catalunya), R7 expressway (Slovakia), R7 Quad, R7/A (New York City Subway car), Radial Road 7, Renault 7, School District of Webb City R-7, Trenton Line (SEPTA), USS R-7 (SS-84), Vashon Ranger R7, Yamaha YZF-R7, 7R.

AMD Radeon Rx 200 series

The AMD Radeon R5/R7/R9 200 series is a family of GPUs developed by AMD.

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Aserca Airlines

Aserca Airlines C.A. (Aero Servicios Carabobo) was an airline based in Valencia, Carabobo, Venezuela.

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ATC code R07


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Chestnut Hill East Line

The Chestnut Hill East Line is a route of the SEPTA Regional Rail (commuter rail) system.

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D7 motorway (Czech Republic)

D7 motorway (Dálnice D7), formerly Expressway R7 (rychlostní silnice R7) is a highway northwest from Prague to Chomutov and German border.

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Grupo Record

Grupo Record is the third largest media company in Brazil, the company owns several television stations as the RecordTV and Record News, was founded in November 1989 and belongs to the businessman and bishop Edir Macedo.

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Leica R4-R7

Leica R4, R5, R6, R7 were 35mm SLR cameras manufactured by Leica between 1980 and 1996.

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List of motorways in Belgium

In Belgium, the motorways (autosnelwegen; autoroutes; Autobahnen) are indicated by an A and an E(uropean) number.

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List of R-phrases

R-phrases (short for risk phrases) are defined in Annex III of European Union Directive 67/548/EEC: Nature of special risks attributed to dangerous substances and preparations.

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R-7 (rocket family)

The R-7 family of rockets (Р-7) is a series of rockets, derived from the Soviet R-7 Semyorka, the world's first ICBM.

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R-7 Semyorka

The R-7 (Р-7 "Семёрка") was a Soviet missile developed during the Cold War, and the world's first intercontinental ballistic missile.

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R7 (drug)

R7 is a small-molecule flavonoid and orally active, potent, and selective agonist of the tropomyosin receptor kinase B (TrkB) – the main signaling receptor for the neurotrophin brain-derived neurotrophic factor (BDNF) – which is under development for the treatment of Alzheimer's disease. It is a structural modification and prodrug of 7,8-dihydroxyflavone (7,8-DHF) with improved potency and pharmacokinetics, namely oral bioavailability and duration. R7 was synthesized by the same researchers who were involved in the discovery of 7,8-DHF. A patent was filed for R7 in 2013 and was published in 2015. In 2016, it was reported to be in the preclinical stage of development. R7 was superseded by R13 because while R7 had a good drug profile in animals, it showed almost no conversion into 7,8-DHF in human liver microsomes. In 2010, 7,8-DHF, a naturally occurring flavonoid, was found to act as an agonist of the TrkB with nanomolar affinity (Kd ≈ 320 nM). Subsequently, 7,8-DHF demonstrated robust efficacy in animal models of Alzheimer's disease and a variety of other conditions, making it a highly promising potential therapeutic agent. Unfortunately, due to the presence of a vulnerable catechol group on its 2-phenyl-4H-chromene ring, 7,8-DHF is extensively conjugated via glucuronidation, sulfation, and methylation during first-pass metabolism in the liver and has a poor oral bioavailability of only 5% in mice upon oral administration. As such, 7,8-DHF itself is a poor candidate for clinical development as an oral medication. R7 is a derivative of 7,8-DHF with carbamate moieties on its hydroxyl groups, thereby protecting it from metabolism. As R7 is a slightly larger molecule than 7,8-DHF, 72.5 mg R7 is molecularly equivalent to 50 mg 7,8-DHF. Relative to a roughly molecularly equivalent dose of 7,8-DHF, the area-under-curve levels of R7 were found to be 7.2-fold higher upon oral administration to mice, and R7 hence has a greatly improved oral bioavailability in mice of approximately 35%. Moreover, whereas 7,8-DHF itself is mostly metabolized in mice within 30 minutes, 7,8-DHF was still detectable in plasma at 8 hours after administration with R7, indicating that R7 sustainably releases 7,8-DHF into circulation. In accordance, the terminal half-life of R7 is about 195 minutes (3.25 hours) in mice. The Tmax of R7 is about 60 minutes in mice, and its Cmax for a 78 mg/kg dose was 262 ng/mL, whereas that for a 50 mg/kg dose of 7,8-DHF was 70 ng/mL. Like 7,8-DHF, administration of R7 has been found to activate the TrkB in vivo in the mouse brain. Moreover, R7 was found to potently activate the TrkB and the downstream Akt signaling pathway upon oral administration, an action that was tightly correlated with plasma concentrations of 7,8-DHF. As such, R7 has shown in vivo efficacy as an agonist of the TrkB, including central activity, similarly to 7,8-DHF.

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R7 (Rodalies de Catalunya)

The R7 is a line of Rodalies de Catalunya's Barcelona commuter rail service, operated by Renfe Operadora.

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R7 expressway (Slovakia)

R7 is a planned expressway in southern Slovakia.

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R7 Quad

The R7 Quad is a line of golf clubs manufactured by TaylorMade.

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R7/A (New York City Subway car)

The R7 (and R7A) was a New York City Subway car model built from 1937 to 1938 for the city-operated Independent Subway System by two manufacturers under separate orders, the American Car and Foundry Company and Pullman Standard.

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Radial Road 7

Radial Road 7 is a network of roads in Metro Manila, connecting the cities of Manila, Quezon City and Caloocan, as well as San Jose del Monte in the province of Bulacan.

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Renault 7

The Renault 7 (or "R7") is a 4-door saloon version of the Renault 5 supermini, produced and sold in Spain by Renault's subsidiary, FASA-Renault from 1974 to 1984.

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School District of Webb City R-7

School District of Webb City R-7 is in Webb City, Jasper County, Missouri, USA.

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Trenton Line (SEPTA)

The Trenton Line is a route of the SEPTA Regional Rail (commuter rail) system.

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USS R-7 (SS-84)

USS R-7 (SS-84) was an ''R''-class coastal and harbor defense submarine of the United States Navy.

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Vashon Ranger R7

The Vashon Ranger R7 is an American light-sport aircraft designed and produced by Vashon Aircraft of Woodinville, Washington.

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Yamaha YZF-R7

The Yamaha YZF-R7 or OW-02 is a race homologation motorcycle made by Yamaha in limited production run of only 500 units.

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7R may refer to.

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Redirects here:

Expressway R7, R 7, R-7, R7 (SEPTA), R7 (disambiguation), Receptor 7, Р-7.


[1] https://en.wikipedia.org/wiki/R7

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