Get it on Google Play
New! Download Unionpedia on your Android™ device!
Faster access than browser!

RNA splicing

Index RNA splicing

In molecular biology, splicing is the editing of the nascent precursor messenger RNA (pre-mRNA) transcript into a mature messenger RNA (mRNA). [1]

82 relations: Adenosine monophosphate, Adenosine triphosphate, Alternative splicing, Archaea, BRCA1, Catalysis, Cell nucleus, Complementary DNA, DNA damage (naturally occurring), DNA repair, Domain (biology), Drosophila melanogaster, Endonuclease, ERCC1, Eukaryote, Eukaryotic transcription, Exon, Exon junction complex, Five-prime cap, Gene, Group I catalytic intron, Group II intron, Group III intron, Indel, Intein, Intron, Journal Citation Reports, Kingdom (biology), Ligation (molecular biology), Mature messenger RNA, Messenger RNA, Minor spliceosome, Molecular biology, Morpholino, Non-coding RNA, Nonsense-mediated decay, Nuclear gene, Nucleic acid notation, Nucleophile, Oligonucleotide, Peptide nucleic acid, Point mutation, Polyadenylation, Polypyrimidine tract, Post-transcriptional modification, Post-translational modification, Precursor mRNA, Prokaryote, Protein, Pyrimidine, ..., Reading frame, Ribosomal RNA, Ribozyme, RNA world, Saccharomyces cerevisiae, SF1 (gene), SnRNP, Spliceosome, Stop codon, SWAP protein domain, Thomson Reuters, Trans-splicing, Transcription (biology), Transesterification, Transfer RNA, TSEN15, TSEN2, TSEN34, U1 spliceosomal RNA, U11 spliceosomal RNA, U12 minor spliceosomal RNA, U2 small nuclear RNA auxiliary factor 1, U2 spliceosomal RNA, U2AF2, U4 spliceosomal RNA, U4atac minor spliceosomal RNA, U5 spliceosomal RNA, U6 spliceosomal RNA, U6atac minor spliceosomal RNA, Ultrabithorax, Web of Science, Yeast. Expand index (32 more) »

Adenosine monophosphate

Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide.

New!!: RNA splicing and Adenosine monophosphate · See more »

Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

New!!: RNA splicing and Adenosine triphosphate · See more »

Alternative splicing

Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.

New!!: RNA splicing and Alternative splicing · See more »


Archaea (or or) constitute a domain of single-celled microorganisms.

New!!: RNA splicing and Archaea · See more »


BRCA1 and BRCA1 are a human gene and its protein product, respectively.

New!!: RNA splicing and BRCA1 · See more »


Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

New!!: RNA splicing and Catalysis · See more »

Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

New!!: RNA splicing and Cell nucleus · See more »

Complementary DNA

In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.

New!!: RNA splicing and Complementary DNA · See more »

DNA damage (naturally occurring)

DNA damage is distinctly different from mutation, although both are types of error in DNA.

New!!: RNA splicing and DNA damage (naturally occurring) · See more »

DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

New!!: RNA splicing and DNA repair · See more »

Domain (biology)

In biological taxonomy, a domain (Latin: regio), also superkingdom or empire, is the highest taxonomic rank of organisms in the three-domain system of taxonomy designed by Carl Woese, an American microbiologist and biophysicist.

New!!: RNA splicing and Domain (biology) · See more »

Drosophila melanogaster

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.

New!!: RNA splicing and Drosophila melanogaster · See more »


Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain.

New!!: RNA splicing and Endonuclease · See more »


DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene.

New!!: RNA splicing and ERCC1 · See more »


Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).

New!!: RNA splicing and Eukaryote · See more »

Eukaryotic transcription

Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of RNA replica.

New!!: RNA splicing and Eukaryotic transcription · See more »


An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

New!!: RNA splicing and Exon · See more »

Exon junction complex

An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing.

New!!: RNA splicing and Exon junction complex · See more »

Five-prime cap

In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA.

New!!: RNA splicing and Five-prime cap · See more »


In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: RNA splicing and Gene · See more »

Group I catalytic intron

Group I introns are large self-splicing ribozymes.

New!!: RNA splicing and Group I catalytic intron · See more »

Group II intron

Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life.

New!!: RNA splicing and Group II intron · See more »

Group III intron

Group III intron is a class of introns found in mRNA genes of chloroplasts in euglenid protists.

New!!: RNA splicing and Group III intron · See more »


Indel is a molecular biology term for an '''in'''sertion or '''del'''etion of bases in the genome of an organism.

New!!: RNA splicing and Indel · See more »


An intein is a segment of a protein that is able to excise itself and join the remaining portions (the exteins) with a peptide bond in a process termed protein splicing.

New!!: RNA splicing and Intein · See more »


An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.

New!!: RNA splicing and Intron · See more »

Journal Citation Reports

Journal Citation Reports (JCR) is an annual publication by Clarivate Analytics (previously the intellectual property of Thomson Reuters).

New!!: RNA splicing and Journal Citation Reports · See more »

Kingdom (biology)

In biology, kingdom (Latin: regnum, plural regna) is the second highest taxonomic rank, just below domain.

New!!: RNA splicing and Kingdom (biology) · See more »

Ligation (molecular biology)

In molecular biology, ligation is the joining of two nucleic acid fragments through the action of an enzyme.

New!!: RNA splicing and Ligation (molecular biology) · See more »

Mature messenger RNA

Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis.

New!!: RNA splicing and Mature messenger RNA · See more »

Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

New!!: RNA splicing and Messenger RNA · See more »

Minor spliceosome

The minor spliceosome is a ribonucleoprotein complex that catalyses the removal (splicing) of an atypical class of spliceosomal introns (U12-type) from eukaryotic messenger RNAs in plants, insects, vertebrates and some fungi (Rhizopus oryzae).

New!!: RNA splicing and Minor spliceosome · See more »

Molecular biology

Molecular biology is a branch of biology which concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions.

New!!: RNA splicing and Molecular biology · See more »


A Morpholino, also known as a Morpholino oligomer and as a phosphorodiamidate Morpholino oligomer (PMO), is a type of oligomer molecule (colloquially, an oligo) used in molecular biology to modify gene expression.

New!!: RNA splicing and Morpholino · See more »

Non-coding RNA

A non-coding RNA (ncRNA) is an RNA molecule that is not translated into a protein.

New!!: RNA splicing and Non-coding RNA · See more »

Nonsense-mediated decay

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes.

New!!: RNA splicing and Nonsense-mediated decay · See more »

Nuclear gene

A nuclear gene is a gene located in the cell nucleus of a eukaryote.

New!!: RNA splicing and Nuclear gene · See more »

Nucleic acid notation

The nucleic acid notation currently in use was first formalized by the International Union of Pure and Applied Chemistry (IUPAC) in 1970.

New!!: RNA splicing and Nucleic acid notation · See more »


Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.

New!!: RNA splicing and Nucleophile · See more »


Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.

New!!: RNA splicing and Oligonucleotide · See more »

Peptide nucleic acid

Peptide nucleic acid (PNA) is an artificially synthesized polymer similar to DNA or RNA.

New!!: RNA splicing and Peptide nucleic acid · See more »

Point mutation

A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA.

New!!: RNA splicing and Point mutation · See more »


Polyadenylation is the addition of a poly(A) tail to a messenger RNA.

New!!: RNA splicing and Polyadenylation · See more »

Polypyrimidine tract

The polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying out RNA splicing during the process of post-transcriptional modification.

New!!: RNA splicing and Polypyrimidine tract · See more »

Post-transcriptional modification

Post-transcriptional modification or Co-transcriptional modification is the process in eukaryotic cells where primary transcript RNA is converted into mature RNA.

New!!: RNA splicing and Post-transcriptional modification · See more »

Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

New!!: RNA splicing and Post-translational modification · See more »

Precursor mRNA

Precursor mRNA (pre-mRNA) is an immature single strand of messenger ribonucleic acid (mRNA).

New!!: RNA splicing and Precursor mRNA · See more »


A prokaryote is a unicellular organism that lacks a membrane-bound nucleus, mitochondria, or any other membrane-bound organelle.

New!!: RNA splicing and Prokaryote · See more »


Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

New!!: RNA splicing and Protein · See more »


Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine.

New!!: RNA splicing and Pyrimidine · See more »

Reading frame

In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets.

New!!: RNA splicing and Reading frame · See more »

Ribosomal RNA

Ribosomal ribonucleic acid (rRNA) is the RNA component of the ribosome, and is essential for protein synthesis in all living organisms.

New!!: RNA splicing and Ribosomal RNA · See more »


Ribozymes (ribonucleic acid enzymes) are RNA molecules that are capable of catalyzing specific biochemical reactions, similar to the action of protein enzymes.

New!!: RNA splicing and Ribozyme · See more »

RNA world

The RNA world is a hypothetical stage in the evolutionary history of life on Earth, in which self-replicating RNA molecules proliferated before the evolution of DNA and proteins.

New!!: RNA splicing and RNA world · See more »

Saccharomyces cerevisiae

Saccharomyces cerevisiae is a species of yeast.

New!!: RNA splicing and Saccharomyces cerevisiae · See more »

SF1 (gene)

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.

New!!: RNA splicing and SF1 (gene) · See more »


snRNPs (pronounced "snurps"), or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.

New!!: RNA splicing and SnRNP · See more »


A spliceosome is a large and complex molecular machine found primarily within the splicing speckles of the cell nucleus of eukaryotic cells.

New!!: RNA splicing and Spliceosome · See more »

Stop codon

In the genetic code, a stop codon (or termination codon) is a nucleotide triplet within messenger RNA that signals a termination of translation into proteins.

New!!: RNA splicing and Stop codon · See more »

SWAP protein domain

In molecular biology, the protein domain SWAP is derived from the term Suppressor-of-White-APricot, a splicing regulator from the model organism Drosophila melanogaster.

New!!: RNA splicing and SWAP protein domain · See more »

Thomson Reuters

Thomson Reuters Corporation is a Canadian multinational mass media and information firm.

New!!: RNA splicing and Thomson Reuters · See more »


Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.

New!!: RNA splicing and Trans-splicing · See more »

Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

New!!: RNA splicing and Transcription (biology) · See more »


In organic chemistry, transesterfication is the process of exchanging the organic group R″ of an ester with the organic group R′ of an alcohol.

New!!: RNA splicing and Transesterification · See more »

Transfer RNA

A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins.

New!!: RNA splicing and Transfer RNA · See more »


tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.

New!!: RNA splicing and TSEN15 · See more »


tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.

New!!: RNA splicing and TSEN2 · See more »


tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.

New!!: RNA splicing and TSEN34 · See more »

U1 spliceosomal RNA

U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP (small nuclear ribonucleoprotein), an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.

New!!: RNA splicing and U1 spliceosomal RNA · See more »

U11 spliceosomal RNA

The U11 snRNA (small nuclear ribonucleic acid) is an important non-coding RNA in the minor spliceosome protein complex, which activates the alternative splicing mechanism.

New!!: RNA splicing and U11 spliceosomal RNA · See more »

U12 minor spliceosomal RNA

U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns.

New!!: RNA splicing and U12 minor spliceosomal RNA · See more »

U2 small nuclear RNA auxiliary factor 1

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

New!!: RNA splicing and U2 small nuclear RNA auxiliary factor 1 · See more »

U2 spliceosomal RNA

U2 spliceosomal snRNAs are a species of small nuclear RNA (snRNA) molecules found in the major spliceosomal (Sm) machinery of virtually all-eukaryotic organisms.

New!!: RNA splicing and U2 spliceosomal RNA · See more »


Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

New!!: RNA splicing and U2AF2 · See more »

U4 spliceosomal RNA

The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA).

New!!: RNA splicing and U4 spliceosomal RNA · See more »

U4atac minor spliceosomal RNA

U4atac minor spliceosomal RNA is a ncRNA which is an essential component of the minor U12-type spliceosome complex.

New!!: RNA splicing and U4atac minor spliceosomal RNA · See more »

U5 spliceosomal RNA

U5 RNA is a non-coding RNA that is a component of both types of known spliceosome.

New!!: RNA splicing and U5 spliceosomal RNA · See more »

U6 spliceosomal RNA

U6 snRNA is the non-coding small nuclear RNA (snRNA) component of U6 snRNP (small nuclear ribonucleoprotein), an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex that catalyzes the excision of introns from pre-mRNA.

New!!: RNA splicing and U6 spliceosomal RNA · See more »

U6atac minor spliceosomal RNA

U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex.

New!!: RNA splicing and U6atac minor spliceosomal RNA · See more »


Ultrabithorax (Ubx) is a homeobox gene found in insects, and is used in the regulation of patterning in morphogenesis.

New!!: RNA splicing and Ultrabithorax · See more »

Web of Science

Web of Science (previously known as Web of Knowledge) is an online subscription-based scientific citation indexing service originally produced by the Institute for Scientific Information (ISI), now maintained by Clarivate Analytics (previously the Intellectual Property and Science business of Thomson Reuters), that provides a comprehensive citation search.

New!!: RNA splicing and Web of Science · See more »


Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom.

New!!: RNA splicing and Yeast · See more »

Redirects here:

Cryptic splic site, Cryptic splice site, DNA Splicing, Intron splicing, MRNA splicing, Rna splice sites, Rna splicing, Splice junction, Splice site, Splicing (genetics).


[1] https://en.wikipedia.org/wiki/RNA_splicing

Hey! We are on Facebook now! »