82 relations: Adenosine monophosphate, Adenosine triphosphate, Alternative splicing, Archaea, BRCA1, Catalysis, Cell nucleus, Complementary DNA, DNA damage (naturally occurring), DNA repair, Domain (biology), Drosophila melanogaster, Endonuclease, ERCC1, Eukaryote, Eukaryotic transcription, Exon, Exon junction complex, Five-prime cap, Gene, Group I catalytic intron, Group II intron, Group III intron, Indel, Intein, Intron, Journal Citation Reports, Kingdom (biology), Ligation (molecular biology), Mature messenger RNA, Messenger RNA, Minor spliceosome, Molecular biology, Morpholino, Non-coding RNA, Nonsense-mediated decay, Nuclear gene, Nucleic acid notation, Nucleophile, Oligonucleotide, Peptide nucleic acid, Point mutation, Polyadenylation, Polypyrimidine tract, Post-transcriptional modification, Post-translational modification, Precursor mRNA, Prokaryote, Protein, Pyrimidine, ..., Reading frame, Ribosomal RNA, Ribozyme, RNA world, Saccharomyces cerevisiae, SF1 (gene), SnRNP, Spliceosome, Stop codon, SWAP protein domain, Thomson Reuters, Trans-splicing, Transcription (biology), Transesterification, Transfer RNA, TSEN15, TSEN2, TSEN34, U1 spliceosomal RNA, U11 spliceosomal RNA, U12 minor spliceosomal RNA, U2 small nuclear RNA auxiliary factor 1, U2 spliceosomal RNA, U2AF2, U4 spliceosomal RNA, U4atac minor spliceosomal RNA, U5 spliceosomal RNA, U6 spliceosomal RNA, U6atac minor spliceosomal RNA, Ultrabithorax, Web of Science, Yeast. Expand index (32 more) » « Shrink index
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide.
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
Archaea (or or) constitute a domain of single-celled microorganisms.
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.
DNA damage is distinctly different from mutation, although both are types of error in DNA.
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
In biological taxonomy, a domain (Latin: regio), also superkingdom or empire, is the highest taxonomic rank of organisms in the three-domain system of taxonomy designed by Carl Woese, an American microbiologist and biophysicist.
Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.
Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain.
DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene.
Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).
Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of RNA replica.
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing.
In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Group I introns are large self-splicing ribozymes.
Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life.
Group III intron is a class of introns found in mRNA genes of chloroplasts in euglenid protists.
Indel is a molecular biology term for an '''in'''sertion or '''del'''etion of bases in the genome of an organism.
An intein is a segment of a protein that is able to excise itself and join the remaining portions (the exteins) with a peptide bond in a process termed protein splicing.
An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.
Journal Citation Reports (JCR) is an annual publication by Clarivate Analytics (previously the intellectual property of Thomson Reuters).
In biology, kingdom (Latin: regnum, plural regna) is the second highest taxonomic rank, just below domain.
In molecular biology, ligation is the joining of two nucleic acid fragments through the action of an enzyme.
Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis.
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
The minor spliceosome is a ribonucleoprotein complex that catalyses the removal (splicing) of an atypical class of spliceosomal introns (U12-type) from eukaryotic messenger RNAs in plants, insects, vertebrates and some fungi (Rhizopus oryzae).
Molecular biology is a branch of biology which concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions.
A Morpholino, also known as a Morpholino oligomer and as a phosphorodiamidate Morpholino oligomer (PMO), is a type of oligomer molecule (colloquially, an oligo) used in molecular biology to modify gene expression.
A non-coding RNA (ncRNA) is an RNA molecule that is not translated into a protein.
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes.
A nuclear gene is a gene located in the cell nucleus of a eukaryote.
The nucleic acid notation currently in use was first formalized by the International Union of Pure and Applied Chemistry (IUPAC) in 1970.
Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.
Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.
Peptide nucleic acid (PNA) is an artificially synthesized polymer similar to DNA or RNA.
A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA.
Polyadenylation is the addition of a poly(A) tail to a messenger RNA.
The polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying out RNA splicing during the process of post-transcriptional modification.
Post-transcriptional modification or Co-transcriptional modification is the process in eukaryotic cells where primary transcript RNA is converted into mature RNA.
Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.
Precursor mRNA (pre-mRNA) is an immature single strand of messenger ribonucleic acid (mRNA).
A prokaryote is a unicellular organism that lacks a membrane-bound nucleus, mitochondria, or any other membrane-bound organelle.
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine.
In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets.
Ribosomal ribonucleic acid (rRNA) is the RNA component of the ribosome, and is essential for protein synthesis in all living organisms.
Ribozymes (ribonucleic acid enzymes) are RNA molecules that are capable of catalyzing specific biochemical reactions, similar to the action of protein enzymes.
The RNA world is a hypothetical stage in the evolutionary history of life on Earth, in which self-replicating RNA molecules proliferated before the evolution of DNA and proteins.
Saccharomyces cerevisiae is a species of yeast.
Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.
snRNPs (pronounced "snurps"), or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.
A spliceosome is a large and complex molecular machine found primarily within the splicing speckles of the cell nucleus of eukaryotic cells.
In the genetic code, a stop codon (or termination codon) is a nucleotide triplet within messenger RNA that signals a termination of translation into proteins.
In molecular biology, the protein domain SWAP is derived from the term Suppressor-of-White-APricot, a splicing regulator from the model organism Drosophila melanogaster.
Thomson Reuters Corporation is a Canadian multinational mass media and information firm.
Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
In organic chemistry, transesterfication is the process of exchanging the organic group R″ of an ester with the organic group R′ of an alcohol.
A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins.
tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.
tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.
tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.
U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP (small nuclear ribonucleoprotein), an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.
The U11 snRNA (small nuclear ribonucleic acid) is an important non-coding RNA in the minor spliceosome protein complex, which activates the alternative splicing mechanism.
U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns.
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.
U2 spliceosomal snRNAs are a species of small nuclear RNA (snRNA) molecules found in the major spliceosomal (Sm) machinery of virtually all-eukaryotic organisms.
Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.
The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA).
U4atac minor spliceosomal RNA is a ncRNA which is an essential component of the minor U12-type spliceosome complex.
U5 RNA is a non-coding RNA that is a component of both types of known spliceosome.
U6 snRNA is the non-coding small nuclear RNA (snRNA) component of U6 snRNP (small nuclear ribonucleoprotein), an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex that catalyzes the excision of introns from pre-mRNA.
U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex.
Ultrabithorax (Ubx) is a homeobox gene found in insects, and is used in the regulation of patterning in morphogenesis.
Web of Science (previously known as Web of Knowledge) is an online subscription-based scientific citation indexing service originally produced by the Institute for Scientific Information (ISI), now maintained by Clarivate Analytics (previously the Intellectual Property and Science business of Thomson Reuters), that provides a comprehensive citation search.
Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom.