9 relations: Allosteric modulator, Cognitive deficit, Down syndrome, GABAA receptor, GABAA receptor negative allosteric modulator, GABRA5, Hoffmann-La Roche, Inverse agonist, List of investigational antipsychotics.
Allosteric modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
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Cognitive deficit
Cognitive deficit or cognitive impairment is an inclusive term to describe any characteristic that acts as a barrier to the cognition process.
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Down syndrome
Down syndrome (DS or DNS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21.
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GABAA receptor
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
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GABAA receptor negative allosteric modulator
A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
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GABRA5
Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene.
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Hoffmann-La Roche
F.
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Inverse agonist
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
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List of investigational antipsychotics
This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved.
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RG 1662, RG-1662, RG1662, RO 5186582, RO-5186582, RO5186582, Ro 5186582, Ro-5186582, Ro5186582.