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Radafaxine is drug candidate designated GW-353,162 by GlaxoSmithKline, investigated for treatment of restless leg syndrome and as an NDRI antidepressant. [1]

20 relations: Bupropion, Clinical trial, Dopamine, Drug, Fatigue, G-130, GlaxoSmithKline, Hydroxybupropion, Major depressive disorder, Manifaxine, Norepinephrine, Norepinephrine–dopamine reuptake inhibitor, Obesity, Pain, Peripheral neuropathy, Phenmetrazine, Restless legs syndrome, Reuptake, Substance abuse, 2-Phenyl-3,6-dimethylmorpholine.


Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used as an antidepressant and smoking cessation aid.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.

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Fatigue is a subjective feeling of tiredness that has a gradual onset.

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G-130 (GP-130, 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine) is a drug with stimulant and anorectic effects, related to phenmetrazine.

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GlaxoSmithKline plc (GSK) is a British pharmaceutical company headquartered in Brentford, London.

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Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Manifaxine (GW-320,659) is a drug developed by GlaxoSmithKline through structural modification of radafaxine, one of the major active metabolites of bupropion.

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Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Norepinephrine–dopamine reuptake inhibitor

A norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively.

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Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Pain is a distressing feeling often caused by intense or damaging stimuli.

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Peripheral neuropathy

Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.

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Phenmetrazine (INN, USAN, BAN) (brand name Preludin, and many others) is a stimulant drug that was previously used as an appetite suppressant, but has since been withdrawn from the market.

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Restless legs syndrome

Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one's legs.

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Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

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Substance abuse

Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.

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2-Phenyl-3,6-dimethylmorpholine is a drug with stimulant and anorectic effects, related to phenmetrazine.

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Redirects here:

(2S,3S)-Hydroxybupropion, (2S,3S)-hydroxybupropion, (S,S)-Hydroxybupropion, (S,S)-hydroxybupropion, (SS)-Hydroxybupropion, (SS)-hydroxybupropion, 2S,3S-Hydroxybupropion, 2S,3S-hydroxybupropion, S,S-Hydroxybupropion, S,S-hydroxybupropion, SS-Hydroxybupropion, SS-hydroxybupropion.


[1] https://en.wikipedia.org/wiki/Radafaxine

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