Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Android™ device!
Free
Faster access than browser!
 

Receptor tyrosine kinase

Index Receptor tyrosine kinase

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. [1]

87 relations: Adenosine triphosphate, Alzheimer's disease, Amino acid, Angiopoietin receptor, Antibody, AXL receptor tyrosine kinase, Bcr-Abl tyrosine-kinase inhibitor, Biochemistry, Blood vessel, Brain, C-Met, C-terminus, Cancer, Cell surface receptor, Co-receptor, Collagen, Cytokine, DDR1, Embryo, Endothelium, Enzyme, Enzyme-linked receptor, Ephrin receptor, ErbB, Extracellular, Fibroblast growth factor, Fibroblast growth factor receptor, Gene, Glial cell line-derived neurotrophic factor, Glycosylphosphatidylinositol, Growth factor, Heart, High-energy phosphate, Hormone, Human genome, Immunoglobulin superfamily, In vivo, Insulin receptor, Intracellular, Kinase, Kinase insert domain receptor, Leukocyte receptor tyrosine kinase, Ligand (biochemistry), Lung, Lymphangiogenesis, Malignancy, Mitogen-activated protein kinase, Monomer, Multiple sclerosis, MuSK protein, ..., Myogenesis, N-terminus, Neoplasm, Neurodegeneration, Non-receptor tyrosine kinase, Paracrine signalling, Phosphatase, Phosphate, Phospholipase C, Phosphorylation, Platelet-derived growth factor receptor, Protein complex, Protein dimer, Protein domain, Protein isoform, Protein subunit, Proto-oncogene tyrosine-protein kinase Src, PTK7, Receptor tyrosine kinase-like orphan receptor, Recombinant DNA, Related to receptor tyrosine kinase, Residue (chemistry), RET proto-oncogene, RTK class III, SH2 domain, Signal transducing adaptor protein, Signal transduction, Skin, Substrate (chemistry), Transmembrane protein, Trk receptor, Tyrosine, Tyrosine kinase, Tyrosine-kinase inhibitor, Vascular endothelial growth factor, VEGF receptor, VEGFR1. Expand index (37 more) »

Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

New!!: Receptor tyrosine kinase and Adenosine triphosphate · See more »

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

New!!: Receptor tyrosine kinase and Alzheimer's disease · See more »

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

New!!: Receptor tyrosine kinase and Amino acid · See more »

Angiopoietin receptor

The angiopoietin receptors are receptors that bind angiopoietin.

New!!: Receptor tyrosine kinase and Angiopoietin receptor · See more »

Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

New!!: Receptor tyrosine kinase and Antibody · See more »

AXL receptor tyrosine kinase

Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.

New!!: Receptor tyrosine kinase and AXL receptor tyrosine kinase · See more »

Bcr-Abl tyrosine-kinase inhibitor

Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML).

New!!: Receptor tyrosine kinase and Bcr-Abl tyrosine-kinase inhibitor · See more »

Biochemistry

Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms.

New!!: Receptor tyrosine kinase and Biochemistry · See more »

Blood vessel

The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.

New!!: Receptor tyrosine kinase and Blood vessel · See more »

Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

New!!: Receptor tyrosine kinase and Brain · See more »

C-Met

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.

New!!: Receptor tyrosine kinase and C-Met · See more »

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

New!!: Receptor tyrosine kinase and C-terminus · See more »

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

New!!: Receptor tyrosine kinase and Cancer · See more »

Cell surface receptor

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.

New!!: Receptor tyrosine kinase and Cell surface receptor · See more »

Co-receptor

A co-receptor is a cell surface receptor that binds a signalling molecule in addition to a primary receptor in order to facilitate ligand recognition and initiate biological processes, such as entry of a pathogen into a host cell.

New!!: Receptor tyrosine kinase and Co-receptor · See more »

Collagen

Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

New!!: Receptor tyrosine kinase and Collagen · See more »

Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

New!!: Receptor tyrosine kinase and Cytokine · See more »

DDR1

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.

New!!: Receptor tyrosine kinase and DDR1 · See more »

Embryo

An embryo is an early stage of development of a multicellular diploid eukaryotic organism.

New!!: Receptor tyrosine kinase and Embryo · See more »

Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

New!!: Receptor tyrosine kinase and Endothelium · See more »

Enzyme

Enzymes are macromolecular biological catalysts.

New!!: Receptor tyrosine kinase and Enzyme · See more »

Enzyme-linked receptor

An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.

New!!: Receptor tyrosine kinase and Enzyme-linked receptor · See more »

Ephrin receptor

Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins).

New!!: Receptor tyrosine kinase and Ephrin receptor · See more »

ErbB

The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.

New!!: Receptor tyrosine kinase and ErbB · See more »

Extracellular

In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".

New!!: Receptor tyrosine kinase and Extracellular · See more »

Fibroblast growth factor

The fibroblast growth factors are a family of cell signalling proteins that are involved in a wide variety of processes, most notably as crucial elements for normal development.

New!!: Receptor tyrosine kinase and Fibroblast growth factor · See more »

Fibroblast growth factor receptor

The fibroblast growth factor receptors are, as their name implies, receptors that bind to members of the fibroblast growth factor family of proteins.

New!!: Receptor tyrosine kinase and Fibroblast growth factor receptor · See more »

Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: Receptor tyrosine kinase and Gene · See more »

Glial cell line-derived neurotrophic factor

Glial cell-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene.

New!!: Receptor tyrosine kinase and Glial cell line-derived neurotrophic factor · See more »

Glycosylphosphatidylinositol

Glycosylphosphatidylinositol, or glycophosphatidylinositol, or GPI in short, is a glycolipid that can be attached to the C-terminus of a protein during posttranslational modification.

New!!: Receptor tyrosine kinase and Glycosylphosphatidylinositol · See more »

Growth factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.

New!!: Receptor tyrosine kinase and Growth factor · See more »

Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

New!!: Receptor tyrosine kinase and Heart · See more »

High-energy phosphate

High-energy phosphate can mean one of two things.

New!!: Receptor tyrosine kinase and High-energy phosphate · See more »

Hormone

A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

New!!: Receptor tyrosine kinase and Hormone · See more »

Human genome

The human genome is the complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.

New!!: Receptor tyrosine kinase and Human genome · See more »

Immunoglobulin superfamily

The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells.

New!!: Receptor tyrosine kinase and Immunoglobulin superfamily · See more »

In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

New!!: Receptor tyrosine kinase and In vivo · See more »

Insulin receptor

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.

New!!: Receptor tyrosine kinase and Insulin receptor · See more »

Intracellular

In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".

New!!: Receptor tyrosine kinase and Intracellular · See more »

Kinase

In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

New!!: Receptor tyrosine kinase and Kinase · See more »

Kinase insert domain receptor

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor.

New!!: Receptor tyrosine kinase and Kinase insert domain receptor · See more »

Leukocyte receptor tyrosine kinase

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.

New!!: Receptor tyrosine kinase and Leukocyte receptor tyrosine kinase · See more »

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

New!!: Receptor tyrosine kinase and Ligand (biochemistry) · See more »

Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

New!!: Receptor tyrosine kinase and Lung · See more »

Lymphangiogenesis

Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development).

New!!: Receptor tyrosine kinase and Lymphangiogenesis · See more »

Malignancy

Malignancy is the tendency of a medical condition to become progressively worse.

New!!: Receptor tyrosine kinase and Malignancy · See more »

Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).

New!!: Receptor tyrosine kinase and Mitogen-activated protein kinase · See more »

Monomer

A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".

New!!: Receptor tyrosine kinase and Monomer · See more »

Multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

New!!: Receptor tyrosine kinase and Multiple sclerosis · See more »

MuSK protein

MuSK (for Muscle-Specific Kinase) is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction.

New!!: Receptor tyrosine kinase and MuSK protein · See more »

Myogenesis

Myogenesis is the formation of muscular tissue, particularly during embryonic development.

New!!: Receptor tyrosine kinase and Myogenesis · See more »

N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

New!!: Receptor tyrosine kinase and N-terminus · See more »

Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

New!!: Receptor tyrosine kinase and Neoplasm · See more »

Neurodegeneration

Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.

New!!: Receptor tyrosine kinase and Neurodegeneration · See more »

Non-receptor tyrosine kinase

Non-receptor tyrosine kinases (nRTKs) are cytosolic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

New!!: Receptor tyrosine kinase and Non-receptor tyrosine kinase · See more »

Paracrine signalling

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.

New!!: Receptor tyrosine kinase and Paracrine signalling · See more »

Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.

New!!: Receptor tyrosine kinase and Phosphatase · See more »

Phosphate

A phosphate is chemical derivative of phosphoric acid.

New!!: Receptor tyrosine kinase and Phosphate · See more »

Phospholipase C

Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).

New!!: Receptor tyrosine kinase and Phospholipase C · See more »

Phosphorylation

In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.

New!!: Receptor tyrosine kinase and Phosphorylation · See more »

Platelet-derived growth factor receptor

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family.

New!!: Receptor tyrosine kinase and Platelet-derived growth factor receptor · See more »

Protein complex

A protein complex or multiprotein complex is a group of two or more associated polypeptide chains.

New!!: Receptor tyrosine kinase and Protein complex · See more »

Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

New!!: Receptor tyrosine kinase and Protein dimer · See more »

Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

New!!: Receptor tyrosine kinase and Protein domain · See more »

Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

New!!: Receptor tyrosine kinase and Protein isoform · See more »

Protein subunit

In structural biology, a protein subunit is a single protein molecule that assembles (or "coassembles") with other protein molecules to form a protein complex.

New!!: Receptor tyrosine kinase and Protein subunit · See more »

Proto-oncogene tyrosine-protein kinase Src

Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.

New!!: Receptor tyrosine kinase and Proto-oncogene tyrosine-protein kinase Src · See more »

PTK7

Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.

New!!: Receptor tyrosine kinase and PTK7 · See more »

Receptor tyrosine kinase-like orphan receptor

In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity.

New!!: Receptor tyrosine kinase and Receptor tyrosine kinase-like orphan receptor · See more »

Recombinant DNA

Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.

New!!: Receptor tyrosine kinase and Recombinant DNA · See more »

Related to receptor tyrosine kinase

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

New!!: Receptor tyrosine kinase and Related to receptor tyrosine kinase · See more »

Residue (chemistry)

In chemistry residue is whatever remains or acts as a contaminant after a given class of events.

New!!: Receptor tyrosine kinase and Residue (chemistry) · See more »

RET proto-oncogene

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules.

New!!: Receptor tyrosine kinase and RET proto-oncogene · See more »

RTK class III

RTK class III is a class of receptor tyrosine kinases.

New!!: Receptor tyrosine kinase and RTK class III · See more »

SH2 domain

The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.

New!!: Receptor tyrosine kinase and SH2 domain · See more »

Signal transducing adaptor protein

Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway.

New!!: Receptor tyrosine kinase and Signal transducing adaptor protein · See more »

Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

New!!: Receptor tyrosine kinase and Signal transduction · See more »

Skin

Skin is the soft outer tissue covering vertebrates.

New!!: Receptor tyrosine kinase and Skin · See more »

Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

New!!: Receptor tyrosine kinase and Substrate (chemistry) · See more »

Transmembrane protein

A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.

New!!: Receptor tyrosine kinase and Transmembrane protein · See more »

Trk receptor

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

New!!: Receptor tyrosine kinase and Trk receptor · See more »

Tyrosine

Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

New!!: Receptor tyrosine kinase and Tyrosine · See more »

Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.

New!!: Receptor tyrosine kinase and Tyrosine kinase · See more »

Tyrosine-kinase inhibitor

A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases.

New!!: Receptor tyrosine kinase and Tyrosine-kinase inhibitor · See more »

Vascular endothelial growth factor

Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates the formation of blood vessels.

New!!: Receptor tyrosine kinase and Vascular endothelial growth factor · See more »

VEGF receptor

VEGF receptors are receptors for vascular endothelial growth factor (VEGF).

New!!: Receptor tyrosine kinase and VEGF receptor · See more »

VEGFR1

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.

New!!: Receptor tyrosine kinase and VEGFR1 · See more »

Redirects here:

ATP:(protein)-L-tyrosine O-phosphotransferase (receptor-type), EC 2.7.10.1, RTKs, Receptor Tyrosine Kinase, Receptor protein tyrosine kinase, Receptor protein-tyrosine kinase, Receptor protein-tyrosine kinases, Receptor tyrosine kinases, Receptor tyrosine-kinases, Receptor-tyrosine kinases, Tyrosine kinase receptor, Tyrosine kinase receptors.

References

[1] https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase

OutgoingIncoming
Hey! We are on Facebook now! »