87 relations: Adenosine triphosphate, Alzheimer's disease, Amino acid, Angiopoietin receptor, Antibody, AXL receptor tyrosine kinase, Bcr-Abl tyrosine-kinase inhibitor, Biochemistry, Blood vessel, Brain, C-Met, C-terminus, Cancer, Cell surface receptor, Co-receptor, Collagen, Cytokine, DDR1, Embryo, Endothelium, Enzyme, Enzyme-linked receptor, Ephrin receptor, ErbB, Extracellular, Fibroblast growth factor, Fibroblast growth factor receptor, Gene, Glial cell line-derived neurotrophic factor, Glycosylphosphatidylinositol, Growth factor, Heart, High-energy phosphate, Hormone, Human genome, Immunoglobulin superfamily, In vivo, Insulin receptor, Intracellular, Kinase, Kinase insert domain receptor, Leukocyte receptor tyrosine kinase, Ligand (biochemistry), Lung, Lymphangiogenesis, Malignancy, Mitogen-activated protein kinase, Monomer, Multiple sclerosis, MuSK protein, ..., Myogenesis, N-terminus, Neoplasm, Neurodegeneration, Non-receptor tyrosine kinase, Paracrine signalling, Phosphatase, Phosphate, Phospholipase C, Phosphorylation, Platelet-derived growth factor receptor, Protein complex, Protein dimer, Protein domain, Protein isoform, Protein subunit, Proto-oncogene tyrosine-protein kinase Src, PTK7, Receptor tyrosine kinase-like orphan receptor, Recombinant DNA, Related to receptor tyrosine kinase, Residue (chemistry), RET proto-oncogene, RTK class III, SH2 domain, Signal transducing adaptor protein, Signal transduction, Skin, Substrate (chemistry), Transmembrane protein, Trk receptor, Tyrosine, Tyrosine kinase, Tyrosine-kinase inhibitor, Vascular endothelial growth factor, VEGF receptor, VEGFR1. Expand index (37 more) »
Adenosine triphosphate
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Amino acid
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
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Angiopoietin receptor
The angiopoietin receptors are receptors that bind angiopoietin.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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AXL receptor tyrosine kinase
Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.
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Bcr-Abl tyrosine-kinase inhibitor
Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML).
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Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms.
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Blood vessel
The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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C-Met
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cell surface receptor
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.
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Co-receptor
A co-receptor is a cell surface receptor that binds a signalling molecule in addition to a primary receptor in order to facilitate ligand recognition and initiate biological processes, such as entry of a pathogen into a host cell.
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Collagen
Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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DDR1
Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.
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Embryo
An embryo is an early stage of development of a multicellular diploid eukaryotic organism.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme-linked receptor
An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.
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Ephrin receptor
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins).
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ErbB
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.
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Extracellular
In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".
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Fibroblast growth factor
The fibroblast growth factors are a family of cell signalling proteins that are involved in a wide variety of processes, most notably as crucial elements for normal development.
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Fibroblast growth factor receptor
The fibroblast growth factor receptors are, as their name implies, receptors that bind to members of the fibroblast growth factor family of proteins.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glial cell line-derived neurotrophic factor
Glial cell-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene.
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Glycosylphosphatidylinositol
Glycosylphosphatidylinositol, or glycophosphatidylinositol, or GPI in short, is a glycolipid that can be attached to the C-terminus of a protein during posttranslational modification.
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Growth factor
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
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Heart
The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.
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High-energy phosphate
High-energy phosphate can mean one of two things.
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Hormone
A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.
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Human genome
The human genome is the complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.
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Immunoglobulin superfamily
The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Insulin receptor
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.
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Intracellular
In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".
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Kinase
In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.
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Kinase insert domain receptor
Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor.
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Leukocyte receptor tyrosine kinase
Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Lung
The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.
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Lymphangiogenesis
Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar to angiogenesis (blood vessel development).
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Malignancy
Malignancy is the tendency of a medical condition to become progressively worse.
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Mitogen-activated protein kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).
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Monomer
A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".
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Multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
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MuSK protein
MuSK (for Muscle-Specific Kinase) is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction.
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Myogenesis
Myogenesis is the formation of muscular tissue, particularly during embryonic development.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Neoplasm
Neoplasia is a type of abnormal and excessive growth of tissue.
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Neurodegeneration
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
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Non-receptor tyrosine kinase
Non-receptor tyrosine kinases (nRTKs) are cytosolic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.
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Paracrine signalling
Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.
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Phosphatase
A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.
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Phosphate
A phosphate is chemical derivative of phosphoric acid.
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Phospholipase C
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
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Phosphorylation
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
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Platelet-derived growth factor receptor
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family.
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Protein complex
A protein complex or multiprotein complex is a group of two or more associated polypeptide chains.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Protein subunit
In structural biology, a protein subunit is a single protein molecule that assembles (or "coassembles") with other protein molecules to form a protein complex.
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Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.
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PTK7
Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.
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Receptor tyrosine kinase-like orphan receptor
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity.
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Recombinant DNA
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.
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Related to receptor tyrosine kinase
The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.
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Residue (chemistry)
In chemistry residue is whatever remains or acts as a contaminant after a given class of events.
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RET proto-oncogene
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules.
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RTK class III
RTK class III is a class of receptor tyrosine kinases.
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SH2 domain
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.
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Signal transducing adaptor protein
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Skin
Skin is the soft outer tissue covering vertebrates.
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Substrate (chemistry)
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.
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Transmembrane protein
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.
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Trk receptor
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.
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Tyrosine
Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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Tyrosine-kinase inhibitor
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases.
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Vascular endothelial growth factor
Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates the formation of blood vessels.
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VEGF receptor
VEGF receptors are receptors for vascular endothelial growth factor (VEGF).
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VEGFR1
Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.
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Redirects here:
ATP:(protein)-L-tyrosine O-phosphotransferase (receptor-type), EC 2.7.10.1, RTKs, Receptor Tyrosine Kinase, Receptor protein tyrosine kinase, Receptor protein-tyrosine kinase, Receptor protein-tyrosine kinases, Receptor tyrosine kinases, Receptor tyrosine-kinases, Receptor-tyrosine kinases, Tyrosine kinase receptor, Tyrosine kinase receptors.
References
[1] https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase