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Guide RNA

Index Guide RNA

Guide RNAs (a.k.a. gRNA) are the RNAs that guide the insertion or deletion of uridine residues into mitochondrial mRNAs in kinetoplastid protists in a process known as RNA editing. [1]

18 relations: Bodonida, Cas9, Cryptogene, Endonuclease, Euglenid, Flagellum, Genome editing, Kinetoplast, Kinetoplastida, Messenger RNA, Mitochondrion, Nucleoprotein, Protist, Retroposon, RNA, RNA editing, Trypanosomatida, Uridine.

Bodonida

Bodonida is an order of kinetoplastid flagellate excavates.

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Cas9

Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme associated with the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) adaptive immunity system in Streptococcus pyogenes, among other bacteria.

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Cryptogene

A cryptogene is a gene that has had its transcript edited.

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Endonuclease

Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain.

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Euglenid

Euglenids (euglenoids, or euglenophytes, formally Euglenida/Euglenoida, ICZN, or Euglenophyceae, ICBN) are one of the best-known groups of flagellates, which are excavate eukaryotes of the phylum Euglenophyta and their cell structure is typical of that group.

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Flagellum

A flagellum (plural: flagella) is a lash-like appendage that protrudes from the cell body of certain bacterial and eukaryotic cells.

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Genome editing

Genome editing, or genome engineering is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism.

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Kinetoplast

A kinetoplast is a network of circular DNA (called kDNA) inside a large mitochondrion that contains many copies of the mitochondrial genome.

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Kinetoplastida

Kinetoplastida (or Kinetoplastea, as a class) is a group of flagellated protists belonging to the phylum Euglenozoa, and characterised by the presence of an organelle with a large massed DNA called kinetoplast (hence the name).

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Nucleoprotein

Nucleoproteins are any proteins that are structurally associated with nucleic acids, either DNA or RNA.

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Protist

A protist is any eukaryotic organism that has cells with nuclei and is not an animal, plant or fungus.

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Retroposon

Retroposons are repetitive DNA fragments which are inserted into chromosomes after they had been reverse transcribed from any RNA molecule.

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RNA

Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.

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RNA editing

RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase.

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Trypanosomatida

Trypanosomatida is a group of kinetoplastid excavates distinguished by having only a single flagellum.

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Uridine

Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond.

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Redirects here:

GRNA, Rna, guide, Small-guide RNA.

References

[1] https://en.wikipedia.org/wiki/Guide_RNA

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