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Rosai–Dorfman disease

Index Rosai–Dorfman disease

Rosai–Dorfman disease, originally known as sinus histiocytosis with massive lymphadenopathy, is a rare disorder of unknown cause that is characterized by abundant histiocytes in the lymph nodes or other locations throughout the body. [1]

49 relations: Axillary lymphadenopathy, Biopsy, CD1, CD163, CD68, Central nervous system, Cervical lymphadenopathy, Chemotherapy, Disease registry, Emperipolesis, Epstein–Barr virus, Fine-needle aspiration, Granulomatosis with polyangiitis, H&E stain, Histiocyte, Histiocytosis, Human herpesvirus 6, Idiopathic disease, Immunohistochemistry, Inguinal lymphadenopathy, Jilin University, Juan Rosai, Klebsiella, Langerhans cell histiocytosis, Langerhans cell sarcoma, List of cutaneous conditions, Lymph node, Lymphadenopathy, Lymphocyte, Lymphoma, Macrophage colony-stimulating factor, Mediastinal lymphadenopathy, Monocyte, Nasal cavity, Orbit (anatomy), Paranasal sinuses, Parvovirus B19, Plasma cell, Polyomaviridae, Radiation therapy, S100 protein, Salivary gland, Sapienza University of Rome, Sarcoidosis, Signal transduction, Soft tissue, Spontaneous remission, The International League of Dermatological Societies, Tuberculosis.

Axillary lymphadenopathy

Axillary lymphadenopathy is lymphadenopathy of the axillary lymph nodes.

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Biopsy

A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease.

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CD1

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

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CD163

CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene.

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CD68

CD68 ('''C'''luster of '''D'''ifferentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Cervical lymphadenopathy

93-231700-6 service name number Cervical lymphadenopathy refers to lymphadenopathy of the cervical lymph nodes (the glands in the neck).

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Disease registry

Disease or patient registries are collections of secondary data related to patients with a specific diagnosis, condition, or procedure, and they play an important role in post marketing surveillance of pharmaceuticals.

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Emperipolesis

In medicine, emperipolesis is the presence of an intact cell within the cytoplasm of another cell.

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Epstein–Barr virus

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.

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Fine-needle aspiration

Fine-needle aspiration (FNA) is a diagnostic procedure used to investigate lumps or masses.

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Granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), is a long-term systemic disorder that involves both granulomatosis and polyangiitis.

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H&E stain

Hematoxylin and eosin stain or haematoxylin and eosin stain (H&E stain or HE stain) is one of the principal stains in histology.

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Histiocyte

A histiocyte is an animal cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system).

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Histiocytosis

In medicine, histiocytosis is an excessive number of histiocytes (tissue macrophages), and the term is also often used to refer to a group of rare diseases which share this sign as a characteristic.

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Human herpesvirus 6

Human herpesvirus 6 (HHV-6) is the common collective name for human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B).

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Idiopathic disease

An idiopathic disease is any disease with an unknown cause or mechanism of apparently spontaneous origin.

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Immunohistochemistry

Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.

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Inguinal lymphadenopathy

Inguinal lymphadenopathy causes swollen lymph nodes in the groin area.

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Jilin University

Jilin University (JLU;; often abbreviated JLU or 吉大) located in Changchun, founded in 1946, is a leading national research university under the direct jurisdiction of China's Ministry of Education.

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Juan Rosai

Juan Rosai, M.D. (born August, 1940) is an Italian-born American physician who has contributed to clinical research and education in the subspecialty of surgical pathology.

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Klebsiella

Klebsiella is a genus of nonmotile, Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.

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Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a rare disease involving clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes.

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Langerhans cell sarcoma

Langerhans cell sarcoma is a form of malignant histiocytosis.

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List of cutaneous conditions

Many conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Lymphadenopathy

Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number, or consistency.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Macrophage colony-stimulating factor

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types.

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Mediastinal lymphadenopathy

Mediastinal lymphadenopathy or mediastinal adenopathy is an enlargement of the mediastinal lymph nodes.

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Monocyte

Monocytes are a type of leukocyte, or white blood cell.

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Nasal cavity

The nasal cavity (nasal fossa, or nasal passage) is a large air filled space above and behind the nose in the middle of the face.

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Orbit (anatomy)

In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are situated.

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Paranasal sinuses

Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity.

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Parvovirus B19

Primate erythroparvovirus 1, generally referred to as B19 virus, parvovirus B19 or sometimes erythrovirus B19, was the first (and until 2005 the only) known human virus in the family Parvoviridae, genus Erythroparvovirus; it measures only 23–26 nm in diameter.

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Plasma cell

Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies.

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Polyomaviridae

Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds.

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Radiation therapy

Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator.

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S100 protein

The S100 proteins are a family of low-molecular-weight proteins found in vertebrates and characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand type") conformation.

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Salivary gland

The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts.

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Sapienza University of Rome

The Sapienza University of Rome (Italian: Sapienza – Università di Roma), also called simply Sapienza or the University of Rome, is a collegiate research university located in Rome, Italy.

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Sarcoidosis

Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomas.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Soft tissue

In anatomy, soft tissue includes the tissues that connect, support, or surround other structures and organs of the body, not being hard tissue such as bone.

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Spontaneous remission

Spontaneous remission, also called spontaneous healing or spontaneous regression, is an unexpected improvement or cure from a disease that usually progresses.

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The International League of Dermatological Societies

The International League of Dermatological Societies (ILDS) is a non-governmental organization that works closely with the World Health Organization.

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Tuberculosis

Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB).

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Redirects here:

Destombes-Rosai-Dorfman syndrome, Rosai-Dorfman disease, Rosai-Dorfman syndrome, Sinus histiocytosis, Sinus histiocytosis with massive lymphadenopathy.

References

[1] https://en.wikipedia.org/wiki/Rosai–Dorfman_disease

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