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Index S1PR5

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). [1]

5 relations: A-971432, G protein–coupled receptor, Gene, Lysophospholipid receptor, Sphingosine-1-phosphate.


A-971432 is an orally bioavailable selective agonist of sphingosine-1-phosphate receptor 5 (S1PR5) discovered at AbbVie.

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G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Lysophospholipid receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling.

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Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid.

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EDG8, S1P5, S1PR5 (gene).


[1] https://en.wikipedia.org/wiki/S1PR5

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