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14 relations: Bile acid:sodium symporter, Brush border, Constipation, Drug development, Elobixibat, Enterocyte, Enterohepatic circulation, Gene, Ileum, Irritable bowel syndrome, Medication, Non-alcoholic fatty liver disease, Solute carrier family, Volixibat.
Bile acid:sodium symporter
This family of proteins are found both in prokaryotes and eukaryotes.
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Brush border
A brush border (striated border or brush border membrane) is the microvilli-covered surface of simple cuboidal epithelium and simple columnar epithelium cells found in certain locations of the body.
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Constipation
Constipation refers to bowel movements that are infrequent or hard to pass.
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Drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.
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Elobixibat
Elobixibat is an inhibitor of the ileal bile acid transporter (IBAT), undergoing development in clinical trials for the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C).
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Enterocyte
Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestine.
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Enterohepatic circulation
Enterohepatic circulation refers to the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Ileum
The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds.
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Irritable bowel syndrome
Irritable bowel syndrome (IBS) is a group of symptoms—including abdominal pain and changes in the pattern of bowel movements without any evidence of underlying damage.
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Medication
A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
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Non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is one of the types of fatty liver which occurs when fat is deposited (steatosis) in the liver due to causes other than excessive alcohol use.
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Solute carrier family
The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 65 families.
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Volixibat
Volixibat (INN; development code SHP626) is a medication under development as a possible treatment for nonalcoholic steatohepatitis (NASH), the most severe form of non-alcoholic fatty liver disease (NAFLD).
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Apical sodium-bile acid transporter, Apical sodium–bile acid transporter, Ileal bile acid transporter, SLC10A2 (gene).
