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SV40 large T antigen

Index SV40 large T antigen

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. [1]

44 relations: Adenoviridae, Albert Sabin, Amide, Arginine, Asparagine, Aspartic acid, Bioinformatics, Biophysics, Carcinogenesis, Cis-regulatory element, Cysteine, DNA replication, Electrostatics, Genome, Glutamic acid, Human papillomavirus infection, Hydrogen bond, Hydrophobe, Importin α, Leucine, Lysine, Malignant transformation, Maurice Hilleman, Methionine, Mutation, Nuclear localization sequence, P300-CBP coactivator family, P53, Papovavirus, Phenylalanine, Phosphorylation, Polyomaviridae, Proline, Retinoblastoma, Retinoblastoma protein, RNA polymerase II, S phase, Serine, SV40, Threonine, Tumor suppressor, Valine, Van der Waals force, X-ray crystallography.

Adenoviridae

Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome.

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Albert Sabin

Albert Bruce Sabin (born Albert Saperstein; August 26, 1906 – March 3, 1993) was a Polish American medical researcher, best known for developing the oral polio vaccine which has played a key role in nearly eradicating the disease.

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Amide

An amide (or or), also known as an acid amide, is a compound with the functional group RnE(O)xNR′2 (R and R′ refer to H or organic groups).

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Arginine

Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.

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Asparagine

Asparagine (symbol Asn or N), is an α-amino acid that is used in the biosynthesis of proteins.

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Aspartic acid

Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.

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Bioinformatics

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data.

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Biophysics

Biophysics is an interdisciplinary science that applies the approaches and methods of physics to study biological systems.

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Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

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Cis-regulatory element

Cis-regulatory elements (CREs) are regions of non-coding DNA which regulate the transcription of neighboring genes.

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

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Electrostatics

Electrostatics is a branch of physics that studies electric charges at rest.

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Genome

In the fields of molecular biology and genetics, a genome is the genetic material of an organism.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Human papillomavirus infection

Human papillomavirus infection is an infection by human papillomavirus (HPV).

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Hydrophobe

In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.

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Importin α

Importin alpha, or karyopherin alpha refers to a class of adaptor proteins that are involved in the import of proteins into the cell nucleus.

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Leucine

Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.

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Lysine

Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.

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Malignant transformation

Malignant transformation is the process by which cells acquire the properties of cancer.

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Maurice Hilleman

Maurice Ralph Hilleman (August 30, 1919 – April 11, 2005) was an American microbiologist who specialized in vaccinology and developed over 40 vaccines, an unparalleled record of productivity.

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Methionine

Methionine (symbol Met or M) is an essential amino acid in humans.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Nuclear localization sequence

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.

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P300-CBP coactivator family

The p300-CBP coactivator family is composed of two closely related transcriptional co-activating proteins (or coactivators).

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P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Papovavirus

A papovavirus is any member of the former virus family of Papovaviridae.

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Phenylalanine

Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.

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Phosphorylation

In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.

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Polyomaviridae

Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds.

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Proline

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.

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Retinoblastoma

Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye.

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Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.

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RNA polymerase II

RNA polymerase II (RNAP II and Pol II) is a multiprotein complex.

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S phase

S phase (synthesis phase) is the part of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.

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Serine

Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.

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SV40

SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans.

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Threonine

Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.

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Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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Valine

Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.

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Van der Waals force

In molecular physics, the van der Waals forces, named after Dutch scientist Johannes Diderik van der Waals, are distance-dependent interactions between atoms or molecules.

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X-ray crystallography

X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.

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Redirects here:

SV40 Large T-antigen, SV40 TAg, SV40 large T-antigen, Simian virus 40 large T-antigen, T antigen, T-antigen.

References

[1] https://en.wikipedia.org/wiki/SV40_large_T_antigen

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