34 relations: Biologist, Biotinylation, Complementary DNA, Concatemer, DNA microarray, DNA polymerase, DNA sequencer, DNA sequencing, Endonuclease, Expressed sequence tag, GenBank, Gene, Gene expression, Gene expression profiling, Johns Hopkins University, Ligation (molecular biology), Messenger RNA, Microarray, MicroRNA, Neoplasm, P1 phage, Paired-end tag, Polymerase chain reaction, Pyrosequencing, Restriction enzyme, Reverse transcriptase, Reverse transcription polymerase chain reaction, RNA-Seq, Sequence database, Sticky and blunt ends, Tissue (biology), Transcriptome, Transcriptomics technologies, Victor Velculescu.
Biologist
A biologist, is a scientist who has specialized knowledge in the field of biology, the scientific study of life.
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Biotinylation
In biochemistry, biotinylation is the process of covalently attaching biotin to a protein, nucleic acid or other molecule.
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Complementary DNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.
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Concatemer
A concatemer is a long continuous DNA molecule that contains multiple copies of the same DNA sequence linked in series.
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DNA microarray
A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface.
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DNA polymerase
DNA polymerases are enzymes that synthesize DNA molecules from deoxyribonucleotides, the building blocks of DNA.
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DNA sequencer
A DNA sequencer is a scientific instrument used to automate the DNA sequencing process.
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DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule.
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Endonuclease
Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain.
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Expressed sequence tag
In genetics, an expressed sequence tag (EST) is a short sub-sequence of a cDNA sequence.
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GenBank
The GenBank sequence database is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function.
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Johns Hopkins University
Johns Hopkins University is an American private research university in Baltimore, Maryland.
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Ligation (molecular biology)
In molecular biology, ligation is the joining of two nucleic acid fragments through the action of an enzyme.
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Messenger RNA
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
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Microarray
A microarray is a multiplex lab-on-a-chip.
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MicroRNA
A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.
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Neoplasm
Neoplasia is a type of abnormal and excessive growth of tissue.
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P1 phage
P1 is a temperate bacteriophage that infects Escherichia coli and some other bacteria.
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Paired-end tag
Paired-end tags (PET) (sometimes "Paired-End diTags", or simply "ditags") are the short sequences at the 5’ and 3’ ends of a DNA fragment which are unique enough that they (theoretically) exist together only once in a genome, therefore making the sequence of the DNA in between them available upon search (if full-genome sequence data is available) or upon further sequencing (since tag sites are unique enough to serve as primer annealing sites).
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Polymerase chain reaction
Polymerase chain reaction (PCR) is a technique used in molecular biology to amplify a single copy or a few copies of a segment of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.
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Pyrosequencing
Pyrosequencing is a method of DNA sequencing (determining the order of nucleotides in DNA) based on the "sequencing by synthesis" principle, in which the sequencing is performed by detecting the nucleotide incorporated by a DNA polymerase.
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Restriction enzyme
A restriction enzyme or restriction endonuclease is an enzyme that cleaves DNA into fragments at or near specific recognition sites within the molecule known as restriction sites.
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Reverse transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.
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Reverse transcription polymerase chain reaction
Reverse transcription polymerase chain reaction (RT-PCR), a variant of polymerase chain reaction (PCR), is a technique commonly used in molecular biology to detect RNA expression.
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RNA-Seq
RNA-Seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment.
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Sequence database
In the field of bioinformatics, a sequence database is a type of biological database that is composed of a large collection of computerized ("digital") nucleic acid sequences, protein sequences, or other polymer sequences stored on a computer.
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Sticky and blunt ends
DNA ends refer to the properties of the end of DNA molecules, which may be sticky ends (cohesive ends), blunt ends or in other forms.
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Tissue (biology)
In biology, tissue is a cellular organizational level between cells and a complete organ.
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Transcriptome
The transcriptome is the set of all RNA molecules in one cell or a population of cells.
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Transcriptomics technologies
Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts.
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Victor Velculescu
Victor E. Velculescu (born August 16, 1970) is a Professor of Oncology and Co-Director of Cancer Biology at The Johns Hopkins University School of Medicine.
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Redirects here:
LongSAGE, RL-SAGE, Serial Analysis of Gene Expression, SuperSAGE.
References
[1] https://en.wikipedia.org/wiki/Serial_analysis_of_gene_expression