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Serotonin transporter

Index Serotonin transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [1]

Table of Contents

  1. 75 relations: Alcoholism, Allele, Amygdala, Anterior cingulate cortex, Anxiety, Autism, Bioisostere, Bipolar disorder, Brain, Caucasian race, Chemical synapse, Chromosome 17, Clomipramine, Cytoplasm, DASB, Davidson College, Exon, Fluoxetine, Gastrointestinal tract, Gene, Gene–environment interaction, Genotype, Grey matter, Human, Hypertension, Institute of Psychiatry, Psychology and Neuroscience, Intron, Isotope, Isotopes of iodine, Japanese people, Major depressive disorder, Membrane potential, Membrane transport protein, Mental disorder, Meta-analysis, Methcathinone, Monoamine transporter, Mood disorder, Mouse, Neuroticism, Neurotransmitter, Neurotransmitter sodium symporter, Obsessive–compulsive disorder, Odds ratio, Platelet, Polymorphism (biology), Positron emission tomography, Post-traumatic stress disorder, Promoter (genetics), Protein, ... Expand index (25 more) »

  2. Amphetamine
  3. Neurotransmitter transporters
  4. Serotonin

Alcoholism

Alcoholism is the continued drinking of alcohol despite it causing problems.

See Serotonin transporter and Alcoholism

Allele

An allele, or allelomorph, is a variant of the sequence of nucleotides at a particular location, or locus, on a DNA molecule.

See Serotonin transporter and Allele

Amygdala

The amygdala (amygdalae or amygdalas; also corpus amygdaloideum; Latin from Greek, ἀμυγδαλή, amygdalē, 'almond', 'tonsil') is a paired nuclear complex present in the cerebral hemispheres of vertebrates.

See Serotonin transporter and Amygdala

Anterior cingulate cortex

In the human brain, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum.

See Serotonin transporter and Anterior cingulate cortex

Anxiety

Anxiety is an emotion which is characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events.

See Serotonin transporter and Anxiety

Autism

Autism, also called autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental disorder characterised by symptoms of deficient reciprocal social communication and the presence of restricted, repetitive and inflexible patterns of behavior that are impairing in multiple contexts and excessive or atypical to be developmentally and socioculturally inappropriate.

See Serotonin transporter and Autism

Bioisostere

In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties in the same chemical compound.

See Serotonin transporter and Bioisostere

Bipolar disorder

Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that each last from days to weeks.

See Serotonin transporter and Bipolar disorder

Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

See Serotonin transporter and Brain

Caucasian race

The Caucasian race (also Caucasoid, Europid, or Europoid) is an obsolete racial classification of humans based on a now-disproven theory of biological race.

See Serotonin transporter and Caucasian race

Chemical synapse

Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands.

See Serotonin transporter and Chemical synapse

Chromosome 17

Chromosome 17 is one of the 23 pairs of chromosomes in humans. Serotonin transporter and chromosome 17 are genes on human chromosome 17.

See Serotonin transporter and Chromosome 17

Clomipramine

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).

See Serotonin transporter and Clomipramine

Cytoplasm

In cell biology, the cytoplasm describes all material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus.

See Serotonin transporter and Cytoplasm

DASB

DASB, also known as 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, is a compound that binds to the serotonin transporter.

See Serotonin transporter and DASB

Davidson College

Davidson College is a private liberal arts college in Davidson, North Carolina.

See Serotonin transporter and Davidson College

Exon

An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

See Serotonin transporter and Exon

Fluoxetine

Fluoxetine, sold under the brand name Prozac, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

See Serotonin transporter and Fluoxetine

Gastrointestinal tract

The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.

See Serotonin transporter and Gastrointestinal tract

Gene

In biology, the word gene has two meanings.

See Serotonin transporter and Gene

Gene–environment interaction

Gene–environment interaction (or genotype–environment interaction or G×E) is when two different genotypes respond to environmental variation in different ways.

See Serotonin transporter and Gene–environment interaction

Genotype

The genotype of an organism is its complete set of genetic material.

See Serotonin transporter and Genotype

Grey matter

Grey matter, or brain matter in American English, is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries.

See Serotonin transporter and Grey matter

Human

Humans (Homo sapiens, meaning "thinking man") or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo.

See Serotonin transporter and Human

Hypertension

Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

See Serotonin transporter and Hypertension

Institute of Psychiatry, Psychology and Neuroscience

The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) is a leading centre for mental health and neuroscience research, education and training in Europe.

See Serotonin transporter and Institute of Psychiatry, Psychology and Neuroscience

Intron

An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product.

See Serotonin transporter and Intron

Isotope

Isotopes are distinct nuclear species (or nuclides) of the same chemical element.

See Serotonin transporter and Isotope

Isotopes of iodine

There are 37 known isotopes of iodine (53I) from 108I to 144I; all undergo radioactive decay except 127I, which is stable.

See Serotonin transporter and Isotopes of iodine

Japanese people

are an East Asian ethnic group native to the Japanese archipelago.

See Serotonin transporter and Japanese people

Major depressive disorder

Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.

See Serotonin transporter and Major depressive disorder

Membrane potential

Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell.

See Serotonin transporter and Membrane potential

Membrane transport protein

A membrane transport protein is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane.

See Serotonin transporter and Membrane transport protein

Mental disorder

A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.

See Serotonin transporter and Mental disorder

Meta-analysis

Meta-analysis is the statistical combination of the results of multiple studies addressing a similar research question.

See Serotonin transporter and Meta-analysis

Methcathinone

Methcathinone (α-methylamino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.

See Serotonin transporter and Methcathinone

Monoamine transporter

Monoamine transporters (MATs) are proteins that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Serotonin transporter and monoamine transporter are neurotransmitter transporters.

See Serotonin transporter and Monoamine transporter

Mood disorder

A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where a disturbance in the person's mood is the main underlying feature.

See Serotonin transporter and Mood disorder

Mouse

A mouse (mice) is a small rodent.

See Serotonin transporter and Mouse

Neuroticism

Neuroticism is a personality trait associated with negative emotions.

See Serotonin transporter and Neuroticism

Neurotransmitter

A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. Serotonin transporter and neurotransmitter are Molecular neuroscience.

See Serotonin transporter and Neurotransmitter

Neurotransmitter sodium symporter

A neurotransmitter sodium symporter (NSS) is type of neurotransmitter transporter that catalyzes the uptake of a variety of neurotransmitters, amino acids, osmolytes and related nitrogenous substances by a solute:Na+ symport mechanism. Serotonin transporter and neurotransmitter sodium symporter are membrane proteins.

See Serotonin transporter and Neurotransmitter sodium symporter

Obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is a mental and behavioral disorder in which an individual has intrusive thoughts (an obsession) and feels the need to perform certain routines (compulsions) repeatedly to relieve the distress caused by the obsession, to the extent where it impairs general function.

See Serotonin transporter and Obsessive–compulsive disorder

Odds ratio

An odds ratio (OR) is a statistic that quantifies the strength of the association between two events, A and B. The odds ratio is defined as the ratio of the odds of event A taking place in the presence of B, the and odds of A in the absence of B. Due to symmetry, odds ratio reciprocally calculates the ratio of the odds of B occurring in the presence of A, and the odds of B in the absence of A.

See Serotonin transporter and Odds ratio

Platelet

Platelets or thrombocytes are a blood component whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

See Serotonin transporter and Platelet

Polymorphism (biology)

In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

See Serotonin transporter and Polymorphism (biology)

Positron emission tomography

Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption.

See Serotonin transporter and Positron emission tomography

Post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder that develops from experiencing a traumatic event, such as sexual assault, warfare, traffic collisions, child abuse, domestic violence, or other threats on a person's life or well-being.

See Serotonin transporter and Post-traumatic stress disorder

Promoter (genetics)

In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter.

See Serotonin transporter and Promoter (genetics)

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

See Serotonin transporter and Protein

Radioligand

A radioligand is a microscopic particle which consists of a therapeutic radioactive isotope and the cell-targeting compound - the ligand.

See Serotonin transporter and Radioligand

Receptor (biochemistry)

In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.

See Serotonin transporter and Receptor (biochemistry)

Reuptake

Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse. Serotonin transporter and Reuptake are neurotransmitter transporters.

See Serotonin transporter and Reuptake

Revised NEO Personality Inventory

The Revised NEO Personality Inventory (NEO PI-R) is a personality inventory that assesses an individual on five dimensions of personality.

See Serotonin transporter and Revised NEO Personality Inventory

Romance (love)

Romance or romantic love is a feeling of love for, or a strong attraction towards another person, and the courtship behaviors undertaken by an individual to express those overall feelings and resultant emotions.

See Serotonin transporter and Romance (love)

Schizophrenia

Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.

See Serotonin transporter and Schizophrenia

Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.

See Serotonin transporter and Selective serotonin reuptake inhibitor

Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

See Serotonin transporter and Serotonin

Serotonin reuptake inhibitor

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).

See Serotonin transporter and Serotonin reuptake inhibitor

Serotonin transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. Serotonin transporter and serotonin transporter are Amphetamine, biology of bipolar disorder, genes on human chromosome 17, membrane proteins, Molecular neuroscience, neurotransmitter transporters, serotonin and solute carrier family.

See Serotonin transporter and Serotonin transporter

SIDS

Sudden infant death syndrome (SIDS), sometimes known as cot death, is the sudden unexplained death of a child of less than one year of age.

See Serotonin transporter and SIDS

Single-nucleotide polymorphism

In genetics and bioinformatics, a single-nucleotide polymorphism (SNP; plural SNPs) is a germline substitution of a single nucleotide at a specific position in the genome.

See Serotonin transporter and Single-nucleotide polymorphism

Single-photon emission computed tomography

Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays.

See Serotonin transporter and Single-photon emission computed tomography

Social anxiety disorder

Social anxiety disorder (SAD), also known as social phobia, is an anxiety disorder characterized by sentiments of fear and anxiety in social situations, causing considerable distress and impairing ability to function in at least some aspects of daily life.

See Serotonin transporter and Social anxiety disorder

Sodium–potassium pump

The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as -ATPase, pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells.

See Serotonin transporter and Sodium–potassium pump

Solute carrier family

The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families.

See Serotonin transporter and Solute carrier family

Synapse

In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell.

See Serotonin transporter and Synapse

Thalamus

The thalamus (thalami; from Greek θάλαμος, "chamber") is a large mass of gray matter on the lateral walls of the third ventricle forming the dorsal part of the diencephalon (a division of the forebrain).

See Serotonin transporter and Thalamus

Trait theory

In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.

See Serotonin transporter and Trait theory

Transcription (biology)

Transcription is the process of copying a segment of DNA into RNA.

See Serotonin transporter and Transcription (biology)

Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.

See Serotonin transporter and Tricyclic antidepressant

Variable number tandem repeat

A variable number tandem repeat (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandem repeat.

See Serotonin transporter and Variable number tandem repeat

Vasoconstriction

Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.

See Serotonin transporter and Vasoconstriction

Voxel-based morphometry

Voxel-based morphometry is a computational approach to neuroanatomy that measures differences in local concentrations of brain tissue, through a voxel-wise comparison of multiple brain images.

See Serotonin transporter and Voxel-based morphometry

5-HTTLPR

5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene that codes for the serotonin transporter.

See Serotonin transporter and 5-HTTLPR

See also

Amphetamine

Neurotransmitter transporters

Serotonin

References

[1] https://en.wikipedia.org/wiki/Serotonin_transporter

Also known as 5-HT transporter, 5-HTT, 5HTT, HSERT, Human serotonin transporter gene, SLC6A4, SLC6A4 (gene).

, Radioligand, Receptor (biochemistry), Reuptake, Revised NEO Personality Inventory, Romance (love), Schizophrenia, Selective serotonin reuptake inhibitor, Serotonin, Serotonin reuptake inhibitor, Serotonin transporter, SIDS, Single-nucleotide polymorphism, Single-photon emission computed tomography, Social anxiety disorder, Sodium–potassium pump, Solute carrier family, Synapse, Thalamus, Trait theory, Transcription (biology), Tricyclic antidepressant, Variable number tandem repeat, Vasoconstriction, Voxel-based morphometry, 5-HTTLPR.