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Severe combined immunodeficient mice

Index Severe combined immunodeficient mice

Mice with severe combined immunodeficiency (SCIDs) are often used in the research of human disease. [1]

20 relations: Antibody, B cell, B-cell receptor, Cell potency, Clonal anergy, Dengue virus, DNA repair, Gene therapy, Hematopoietic stem cell, HIV, HIV/AIDS, IL-2 receptor, Lymph node, Malaria, Severe combined immunodeficiency, Spleen, T cell, T-cell receptor, Thymus, V(D)J recombination.

Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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B cell

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.

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B-cell receptor

The B-cell receptor or BCR is composed of immunoglobulin molecules that form a type 1 transmembrane receptor protein usually located on the outer surface of a lymphocyte type known as B cells.

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Cell potency

Cell potency is a cell's ability to differentiate into other cell types The more cell types a cell can differentiate into, the greater its potency.

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Clonal anergy

Anergy is a term in immunobiology that describes a lack of reaction by the body's defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance.

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Dengue virus

Dengue virus (DENV) is the cause of dengue fever.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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Gene therapy

In the medicine field, gene therapy (also called human gene transfer) is the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease.

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).

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IL-2 receptor

The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Malaria

Malaria is a mosquito-borne infectious disease affecting humans and other animals caused by parasitic protozoans (a group of single-celled microorganisms) belonging to the Plasmodium type.

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Severe combined immunodeficiency

Severe combined immunodeficiency, SCID, also known as alymphocytosis, Glanzmann–Riniker syndrome, severe mixed immunodeficiency syndrome, and thymic alymphoplasia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in heterogeneous clinical presentations.

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Spleen

The spleen is an organ found in virtually all vertebrates.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T-cell receptor

The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

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Thymus

The thymus is a specialized primary lymphoid organ of the immune system.

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V(D)J recombination

V(D)J recombination is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation.

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References

[1] https://en.wikipedia.org/wiki/Severe_combined_immunodeficient_mice

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