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50 relations: ABVD, Accelerated approval (FDA), Anaplastic large-cell lymphoma, Anemia, Antibody-drug conjugate, Biologics license application, Bleomycin, Boxed warning, Carbamate, Cathepsin B, CD30, Chemotherapy, Chemotherapy-induced peripheral neuropathy, CHOP, Citrulline, Clinical trial, Cutaneous T cell lymphoma, Cyclophosphamide, CYP3A4, Dacarbazine, Diffuse large B-cell lymphoma, Doxorubicin, European Medicines Agency, Food and Drug Administration, Fusion protein, Hodgkin's lymphoma, International nonproprietary name, Lysosome, Maleimide, Marketing authorization, Mitotic inhibitor, Monoclonal antibody, Monomethyl auristatin E, Mycosis fungoides, Neoplasm, Neutropenia, Non-Hodgkin lymphoma, Prednisolone, Prednisone, Progressive multifocal leukoencephalopathy, Relapse, Seattle Genetics, T cell, Therapy, Thrombocytopenia, Tubulin, Upper respiratory tract infection, Valine, Vinblastine, Vincristine.
ABVD
ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, supplanting the older MOPP protocol.
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Accelerated approval (FDA)
The United States Food and Drug Administration (FDA) initiated the FDA Accelerated Approval Program in 1992 to allow faster approval of drugs for serious conditions that fill an unmet medical need.
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Anaplastic large-cell lymphoma
Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T cells or null lymphocytes.
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Anemia
Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.
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Antibody-drug conjugate
Antibody-drug conjugates or ADCs are an important class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer.
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Biologics license application
A biologics license application (BLA) is defined by the U.S. Food and Drug Administration (FDA) as follows: The biologics license application is a request for permission to introduce, or deliver for introduction, a biologic product into interstate commerce (21 CFR 601.2).
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Bleomycin
Bleomycin is a medication used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can be given intravenously, by injection into a muscle or under the skin. It may also be administered inside the chest to help prevent the recurrence of a fluid around the lung due to cancer; however talc is better for this. Common side effects include fever, weight loss, vomiting, and rash. A severe type of anaphylaxis may occur. It may also cause inflammation of the lungs that can result in lung scarring. Chest X-rays every couple of weeks are recommended to check for this. Bleomycin may cause harm to the baby if used during pregnancy. It is believed to primarily work by preventing the making of DNA. Bleomycin was discovered in 1962. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is between 14 USD and 78 USD a dose. It is made by the bacterium Streptomyces verticillus.
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Boxed warning
In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears on the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text.
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Carbamate
A carbamate is an organic compound derived from carbamic acid (NH2COOH).
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Cathepsin B
Cathepsin B is in humans encoded by the CTSB gene.
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CD30
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
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Chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy.
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CHOP
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma.
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Citrulline
The organic compound citrulline is an α-amino acid.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system.
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Cyclophosphamide
Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Dacarbazine
Dacarbazine (DTIC), also known as imidazole carboxamide, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma.
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Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL or DLBL) is a cancer of B cells, a type of white blood cell responsible for producing antibodies.
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Doxorubicin
Doxorubicin, sold under the trade names Adriamycin among others, is a chemotherapy medication used to treat cancer.
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European Medicines Agency
The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Fusion protein
Fusion proteins or chimeric (\kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.
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Hodgkin's lymphoma
Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Lysosome
A lysosome is a membrane-bound organelle found in nearly all animal cells.
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Maleimide
Maleimide is a chemical compound with the formula H2C2(CO)2NH (see diagram).
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Marketing authorization
Process of reviewing and assessing the dossier to support a medicinal product in view of its marketing (also called licensing, registration, approval, etc.), finalized by granting of a document also called marketing authorization (MA) (equivalent: product license).
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Mitotic inhibitor
A mitotic inhibitor is a drug that inhibits mitosis, or cell division.
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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Monomethyl auristatin E
Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent.
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Mycosis fungoides
Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma.
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Neoplasm
Neoplasia is a type of abnormal and excessive growth of tissue.
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Neutropenia
Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.
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Non-Hodgkin lymphoma
Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.
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Prednisolone
Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers.
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Prednisone
Prednisone is a synthetic glucocorticoid drug that is mostly used to suppress the immune system.
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Progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare and usually fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal).
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Relapse
In medicine, relapse or recidivism is a recurrence of a past (typically medical) condition.
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Seattle Genetics
Seattle Genetics is a biotechnology company focused on developing and commercializing innovative, empowered monoclonal antibody-based therapies for the treatment of cancer.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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Therapy
Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.
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Thrombocytopenia
Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.
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Tubulin
Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.
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Upper respiratory tract infection
Upper respiratory tract infections (URTI) are illnesses caused by an acute infection which involves the upper respiratory tract including the nose, sinuses, pharynx or larynx.
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Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.
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Vinblastine
Vinblastine is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer.
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Vincristine
Vincristine, also known as leurocristine and marketed under the brandname Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously. Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low blood white cells. It will likely cause harm to the baby if given during pregnancy. It works by stopping cells from dividing properly. Vincristine was first isolated in 1961. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is between 1.80 and 42.60 USD per dose. It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus.
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Redirects here:
ADCETRIS, ATC code L01XC12, ATCvet code QL01XC12, Adcetris, Brentuximab, ECHELON-1, SGN-35, Sgn35.
References
[1] https://en.wikipedia.org/wiki/Brentuximab_vedotin
