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Aspartate transaminase

Index Aspartate transaminase

Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or serum glutamic oxaloacetic transaminase (SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme that was first described by Arthur Karmen and colleagues in 1954. [1]

52 relations: Acute pancreatitis, Alanine transaminase, Aldimine, Ammonium, Aromatic-amino-acid transaminase, Aspartic acid, AST/ALT ratio, Biomarker, Blood test, Brain, Cardiac muscle, Citric acid cycle, Cytosol, Dermatomyositis, Dicarboxylic acid, Enzyme kinetics, Escherichia coli, Glutamic acid, GOT1, GOT2, Guanidine, Haloferax, Heart, Hemolytic anemia, Hydrogen bond, Hydrolysis, Imine, Inflammation, Keto acid, Kidney, Kidney disease, Liver, Liver function tests, Mitochondrion, Myocardial infarction, Nucleophile, Oxaloacetic acid, Parenchyma, Protein dimer, Pyridoxal phosphate, Pyridoxamine, Quinonoid zwitterion, Rate-determining step, Red blood cell, Reference range, Schiff base, Skeletal muscle, Thermus thermophilus, Transaminase, Troponin, ..., Urea, X-ray crystallography. Expand index (2 more) »

Acute pancreatitis

Acute pancreatitis is a sudden inflammation of the pancreas (pancreatitis).

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Alanine transaminase

Alanine transaminase (ALT) is a transaminase enzyme.

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Aldimine

In organic chemistry, an aldimine is an imine that is an analog of an aldehyde.

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Ammonium

The ammonium cation is a positively charged polyatomic ion with the chemical formula.

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Aromatic-amino-acid transaminase

In enzymology, an aromatic-amino-acid transaminase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are aromatic amino acid and 2-oxoglutarate, whereas its two products are aromatic oxo acid and L-glutamate.

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Aspartic acid

Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.

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AST/ALT ratio

The AST/ALT ratio is the ratio between the concentrations of the enzymes aspartate transaminase (AST) and alanine transaminase (ALT) in the blood of a human or animal.

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Biomarker

A biomarker, or biological marker, generally refers to a measurable indicator of some biological state or condition.

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Blood test

A blood test is a laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick.

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Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

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Cardiac muscle

Cardiac muscle (heart muscle) is one of the three major types of muscle, the others being skeletal and smooth muscle.

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Citric acid cycle

The citric acid cycle (CAC) – also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle – is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP).

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Cytosol

The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Dermatomyositis

Dermatomyositis (DM) is a long term inflammatory disorder which affects muscles.

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Dicarboxylic acid

A dicarboxylic acid is an organic compound containing two carboxyl functional groups (−COOH).

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Enzyme kinetics

Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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GOT1

Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.

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GOT2

Aspartate aminotransferase, mitochondrial is an enzyme that in humans is encoded by the GOT2 gene.

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Guanidine

Guanidine is the compound with the formula HNC(NH2)2.

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Haloferax

In taxonomy, Haloferax is a genus of the Halobacteriaceae or Haloferacaceae.

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Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

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Hemolytic anemia

Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular, but usually in the spleen).

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Hydrolysis

Hydrolysis is a term used for both an electro-chemical process and a biological one.

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Imine

An imine is a functional group or chemical compound containing a carbon–nitrogen double bond.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Keto acid

Keto acids or ketoacids (also called oxo acids or oxoacids) are organic compounds that contain a carboxylic acid group and a ketone group.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Kidney disease

Kidney disease, or renal disease, also known as nephropathy, is damage to or disease of a kidney.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Liver function tests

Liver function tests (LFTs or LFs) are groups of blood tests that give information about the state of a patient's liver.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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Nucleophile

Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.

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Oxaloacetic acid

Oxaloacetic acid (also known as oxalacetic acid) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H.

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Parenchyma

Parenchyma is the bulk of a substance.

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Pyridoxal phosphate

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.

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Pyridoxamine

Pyridoxamine is one form of vitamin B6.

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Quinonoid zwitterion

A quinonoid zwitterion is a special type of zwitterion (or more precisely Mesoionic) based on quinone related chemical compounds.

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Rate-determining step

In chemical kinetics, the overall rate of a reaction is often approximately determined by the slowest step, known as the rate-determining step (RDS) or rate-limiting step.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Reference range

In health-related fields, a reference range or reference interval is the range of values for a physiologic measurement in healthy persons (for example, the amount of creatinine in the blood, or the partial pressure of oxygen).

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Schiff base

A Schiff base (named after Hugo Schiff) is a compound with the general structure R2C.

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Skeletal muscle

Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.

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Thermus thermophilus

Thermus thermophilus is a Gram negative eubacterium used in a range of biotechnological applications, including as a model organism for genetic manipulation, structural genomics, and systems biology.

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Transaminase

Transaminases or aminotransferases are enzymes that catalyze a transamination reaction between an amino acid and an α-keto acid.

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Troponin

bibcode.

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Urea

Urea, also known as carbamide, is an organic compound with chemical formula CO(NH2)2.

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X-ray crystallography

X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.

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Redirects here:

AsT, AspAT, Aspartate amino transferase, Aspartate aminotransferase, Aspartate aminotransferases, Aspartate transferase, EC 2.6.1.1, Glutamic oxalic transaminase, Glutamic oxaloacetic transaminase, L-aspartate:2-oxoglutarate aminotransferase, SGOT, Serum glutamic oxaloacetic transaminase, Serum glutamic-oxaloacetic transaminase, Sgot.

References

[1] https://en.wikipedia.org/wiki/Aspartate_transaminase

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