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82 relations: AC927, Agonist, Alazocine, Antidepressant, Antipsychotic, Arketamine, BD-1047, BD1008, BD1031, BD1052, BD1060, BD1063, BD1067, Benzomorphan, Berberine, BMY-14802, Cell surface receptor, Citalopram, CM156, Cocaine, Cough, Cough medicine, Cutamesine, Dehydroepiandrosterone, Dehydroepiandrosterone sulfate, Dextromethorphan, Dextrorphan, Dimemorfan, Ditolylguanidine, Dysphoria, E-52862, Escitalopram, Fabomotizole, Fluoxetine, Fluvoxamine, Haloperidol, Heroin, Hypertonia, Igmesine, Δ-opioid receptor, Κ-opioid receptor, Μ-opioid receptor, Ketamine, L-687,384, Lamotrigine, Ligand, Ligand (biochemistry), LR132, Memantine, Methamphetamine, ..., Methoxetamine, Methylphenidate, Morphine, Mydriasis, N,N-Dimethyltryptamine, NE-100, NMDA receptor, Noscapine, Opioid, Opioid receptor, Opipramol, Panamesine, PB-28, Pentazocine, Pentoxyverine, Phencyclidine, PRE-084, Pregnenolone, Pregnenolone sulfate, Progesterone, Rimcazole, Sertraline, Sigma receptor, Sigma-1 receptor, Sigma-2 receptor, Siramesine, Stereoisomerism, Tachycardia, Tachypnea, 3-MeO-PCP, 3-PPP, 4-PPBP. Expand index (32 more) »
AC927
AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Alazocine
Alazocine (developmental code name -10047), also known more commonly as N-allylnormetazocine (NANM), is a synthetic opioid analgesic of the benzomorphan family related to metazocine which was never marketed.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Antipsychotic
Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.
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Arketamine
Arketamine, also (R)-ketamine or (R)-(&minus)-ketamine, is the (R)-(&minus) enantiomer of ketamine.
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BD-1047
BD-1047 is a sigma receptor antagonist, selective for the σ1 subtype.
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BD1008
BD1008 or N--N-methyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki.
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BD1031
BD1031 or (R)-2-octahydropyrrolopyrazine is a selective sigma receptor agonist, with a reported binding affinity of Ki.
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BD1052
BD1052 or N--N-2-propen-1-yl-1-pyrrolidineethanamine is a selective sigma receptor agonist, with a reported binding affinity of Ki.
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BD1060
BD1060 or N--1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki.
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BD1063
BD1063 or 1--4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of Ki.
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BD1067
BD1067 or N--N-ethyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki.
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Benzomorphan
Benzomorphan is a chemical compound.
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Berberine
Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as Berberis (e.g. Berberis vulgaris – barberry, Berberis aristata – tree turmeric, Mahonia aquifolium – Oregon-grape, Hydrastis canadensis – goldenseal, Xanthorhiza simplicissima – yellowroot, Phellodendron amurense – Amur cork tree, Coptis chinensis – Chinese goldthread, Tinospora cordifolia, Argemone mexicana – prickly poppy, and Eschscholzia californica – Californian poppy. Berberine is usually found in the roots, rhizomes, stems, and bark. Due to berberine's strong yellow color, Berberis species were used to dye wool, leather, and wood. Wool is still dyed with berberine today in northern India. Under ultraviolet light, berberine shows a strong yellow fluorescence, so it is used in histology for staining heparin in mast cells. As a natural dye, berberine has a color index of 75160.
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BMY-14802
BMY-14802, also known as BMS-181100, is a drug with antipsychotic effects which acts as both a sigma receptor antagonist and a 5-HT1A receptor agonist.
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Cell surface receptor
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.
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Citalopram
Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
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CM156
CM156 is a piperazine based chemical compound with nanomolar affinity for both sigma receptor subtypes that has been shown to counteract the deleterious effects of administered cocaine.
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Cocaine
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.
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Cough
A cough is a sudden and often repetitively occurring, protective reflex, which helps to clear the large breathing passages from fluids, irritants, foreign particles and microbes.
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Cough medicine
Cough medicines are medications used in those with coughing and related conditions.
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Cutamesine
Cutamesine (SA 4503) is a sigma receptor agonist.
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Dehydroepiandrosterone
Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone.
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Dehydroepiandrosterone sulfate
Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex.
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Dextromethorphan
Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).
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Dextrorphan
Dextrorphan (DXO) is a psychoactive drug of the morphinan class which acts as an antitussive or cough suppressant and dissociative hallucinogen.
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Dimemorfan
Dimemorfan (INN) (or dimemorphan) (brand names Astomin, Dastosirr, Tusben), or dimemorfan phosphate (JAN), also known as 3,17-dimethylmorphinan, is an antitussive (cough suppressant) of the morphinan family that is widely used in Japan and is also marketed in Spain and Italy.
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Ditolylguanidine
Ditolylguanidine is a sigma receptor agonist.
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Dysphoria
Dysphoria (from δύσφορος (dysphoros), δυσ-, difficult, and φέρειν, to bear) is a profound state of unease or dissatisfaction.
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E-52862
E-52862, also known as sigma-1 receptor antagonist (S1A, S1RA), as well as MR-309, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki.
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Escitalopram
Escitalopram, sold under the brand names Cipralex and Lexapro among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Fabomotizole
Fabomotizole (INN) (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s.
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Fluoxetine
Fluoxetine, also known by trade names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Fluvoxamine
Fluvoxamine, sold under the brand name Luvox among others, is a medication which is used primarily for the treatment of obsessive–compulsive disorder (OCD), and is also used to treat major depressive disorder and anxiety disorders such as panic disorder and post-traumatic stress disorder.
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Haloperidol
Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication.
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Heroin
Heroin, also known as diamorphine among other names, is an opioid most commonly used as a recreational drug for its euphoric effects.
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Hypertonia
Hypertonia is a term sometimes used synonymously with spasticity and rigidity in the literature surrounding damage to the central nervous system, namely upper motor neuron lesions.
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Igmesine
Igmesine (JO-1,784) is a sigma receptor agonist (IC50.
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Δ-opioid receptor
The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins as its endogenous ligands.
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Κ-opioid receptor
The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.
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Μ-opioid receptor
The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins.
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Ketamine
Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia.
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L-687,384
L-687,384 is a sigma receptor agonist, selective for the σ1 subtype, as well as an NMDA antagonist.
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Lamotrigine
Lamotrigine, sold as the brand name Lamictal among others, is an anticonvulsant medication used to treat epilepsy and bipolar disorder.
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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LR132
LR132 or (+)-3,4-dichloro-N-benzeneethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki.
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Memantine
Memantine is used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors. It was first synthesized by Eli Lilly and Company in 1968 as a potential agent to treat diabetes; the NMDA activity was discovered in the 1980s.
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Methamphetamine
Methamphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity.
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Methoxetamine
Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug.
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Methylphenidate
Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
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Morphine
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.
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Mydriasis
Mydriasis is the dilation of the pupil, usually having a non-physiological cause, or sometimes a physiological pupillary response.
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N,N-Dimethyltryptamine
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.
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NE-100
NE-100 or 4-methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki.
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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Noscapine
Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid from plants of the poppy family, without painkilling properties.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Opioid receptor
Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.
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Opipramol
Opipramol, sold under the brand name Insidon among others, is an anxiolytic and antidepressant which is used throughout Europe.
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Panamesine
Panamesine (developmental code name EMD-57455) is a sigma receptor antagonist that was under development by Merck as a potential antipsychotic for the treatment of schizophrenia in the 1990s but was never marketed.
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PB-28
PB-28 is an agonist of the sigma-2 receptor.
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Pentazocine
Pentazocine, sold under the brand name Talwin among others, is a painkiller used to treat moderate to severe pain.
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Pentoxyverine
Pentoxyverine (rINN) or carbetapentane is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.
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Phencyclidine
Phencyclidine (PCP), also known as angel dust among other names, is a drug used for its mind altering effects.
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PRE-084
PRE-084 is a sigma receptor agonist, selective for the σ1 subtype.
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Pregnenolone
Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids.
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Pregnenolone sulfate
Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone.
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Progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
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Rimcazole
Rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor.
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Sertraline
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Sigma receptor
Schematic σ receptor The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine.
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Sigma-1 receptor
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.
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Sigma-2 receptor
The sigma-2 receptor (σ2R) is a sigma receptor subtype that has been found highly expressed in malignant cancer cells, and is currently under investigation for its potential diagnostic and therapeutic uses.
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Siramesine
Siramesine (or Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype.
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Stereoisomerism
In stereochemistry, stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
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Tachypnea
Tachypnea or tachypnoea is abnormally rapid breathing.
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3-MeO-PCP
3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative hallucinogen of the arylcyclohexylamine class related to phencyclidine (PCP) which has been sold online as a designer drug.
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3-PPP
3-PPP (N-n-propyl-3-(3-hydroxyphenyl)piperidine) is a mixed sigma σ1 and σ2 receptor agonist (with similar affinity for both subtypes, though slightly higher affinity for the latter) and D2 receptor partial agonist which is used in scientific research.
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4-PPBP
4-PPBP is a molecule which binds to sigma receptors.
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Sigma agonist, Sigma antagonist, Sigma receptors, Sigmaergic, Sigmaergics, Sigmamimetic, Sigmamimetics.
References
[1] https://en.wikipedia.org/wiki/Sigma_receptor
