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48 relations: Acetyl group, Adenosine diphosphate ribose, Autoimmune regulator, Caenorhabditis elegans, Calorie restriction, Chromatin, Conserved sequence, Derek Lowe (chemist), DNA repair, Drosophila melanogaster, Enzyme, Enzyme Commission number, Epigenetics, Estrogen-related receptor alpha, European Molecular Biology Laboratory, Gene, Gene expression, HEY2, Homologous recombination, Homology (biology), House mouse, Insulin, Insulin resistance, LMNA, Lysine, Mammal, Methylene blue, MiR-132, Nematode, Nicotinamide, Nicotinamide adenine dinucleotide, P53, Polyphenol, PPARGC1A, Progeria, Protein, Protein–protein interaction, RecQ helicase, Resveratrol, Ribosomal RNA, Ribosome, Sirtuin, SRT1720, T helper 17 cell, Transcription (biology), Werner syndrome, Werner syndrome helicase, Yeast.
Acetyl group
In organic chemistry, acetyl is a moiety, the acyl with chemical formula CH3CO.
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Adenosine diphosphate ribose
Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase.
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Autoimmune regulator
The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene.
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Caenorhabditis elegans
Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.
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Calorie restriction
Calorie restriction, or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients.
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Chromatin
Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.
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Conserved sequence
In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences) or within a genome (paralogous sequences).
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Derek Lowe (chemist)
Derek Lowe is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry, and has written a blog about his field called "In the Pipeline" since 2002.
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DNA repair
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
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Drosophila melanogaster
Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme Commission number
The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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Estrogen-related receptor alpha
Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene.
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European Molecular Biology Laboratory
The European Molecular Biology Laboratory (EMBL) is a molecular biology research institution supported by 25 member states, four prospect and two associate member states.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene.
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Homologous recombination
Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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House mouse
The house mouse (Mus musculus) is a small mammal of the order Rodentia, characteristically having a pointed snout, small rounded ears, and a long naked or almost hairless tail.
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Insulin
Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.
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Insulin resistance
Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin.
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LMNA
Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene.
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Lysine
Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.
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Mammal
Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.
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Methylene blue
Methylene blue, also known as methylthioninium chloride, is a medication and dye.
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MiR-132
In molecular biology miR-132 microRNA is a short non-coding RNA molecule.
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Nematode
The nematodes or roundworms constitute the phylum Nematoda (also called Nemathelminthes).
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Nicotinamide
Nicotinamide (NAA), also known as niacinamide, is a form of vitamin B3 found in food and used as a dietary supplement and medication.
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Nicotinamide adenine dinucleotide
Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.
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P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
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Polyphenol
Polyphenols (also known as polyhydroxyphenols) are a structural class of mainly natural, but also synthetic or semisynthetic, organic chemicals characterized by the presence of large multiples of phenol structural units.
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PPARGC1A
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene.
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Progeria
Progeria is an extremely rare autosomal dominant genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RecQ helicase
RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance.
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Resveratrol
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.
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Ribosomal RNA
Ribosomal ribonucleic acid (rRNA) is the RNA component of the ribosome, and is essential for protein synthesis in all living organisms.
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Ribosome
The ribosome is a complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation).
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Sirtuin
Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity.
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SRT1720
SRT1720 is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1.
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T helper 17 cell
T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).
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Transcription (biology)
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
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Werner syndrome
Werner syndrome (WS), also known as "adult progeria",James, William; Berger, Timothy; Elston, Dirk (2005).
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Werner syndrome helicase
"Werner syndrome ATP-dependent helicase" also known as DNA helicase, RecQ-like type 3 is an enzyme that in humans is encoded by the WRN gene.
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Yeast
Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom.
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Redirects here:
SIR2, SIRT1, SIRT1 (gene), Silent information regulator proteins, saccharomyces cerevisiae, Sir2, Sirt1, Sirtuin1.
References
[1] https://en.wikipedia.org/wiki/Sirtuin_1
