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Strictosidine

Index Strictosidine

Strictosidine is formed by the Pictet–Spengler reaction condensation of tryptamine with secologanin by the enzyme strictosidine synthase. [1]

19 relations: Ajmalicine, Alangiaceae, Apocynaceae, Camptothecin, Icacinaceae, Indole alkaloid, Loganiaceae, Monoterpene, Nyssaceae, Pictet–Spengler reaction, Quinine, Rubiaceae, Saccharomyces cerevisiae, Secologanin, Serpentine (alkaloid), Strictosidine synthase, Tryptamine, Vinblastine, Vincristine.

Ajmalicine

Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure.

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Alangiaceae

Alangiaceae was recognized as a small family of small dicotyledon trees, shrubs or lianas, closely related to the Cornaceae (dogwood family).

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Apocynaceae

Apocynaceae is a family of flowering plants that includes trees, shrubs, herbs, stem succulents, and vines, commonly known as the dogbane family, (Greek for "away from dog" since some taxa were used as dog poison).

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Camptothecin

Camptothecin (CPT) is a topoisomerase inhibitor.

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Icacinaceae

The Icacinaceae are a family of flowering plants,"Icacinaceae" At: Angiosperm Phylogeny Website At: Missouri Botanical Garden Website (see External links below).

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Indole alkaloid

Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids.

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Loganiaceae

The Loganiaceae are a family of flowering plants classified in order Gentianales.

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Monoterpene

Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16.

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Nyssaceae

Nyssaceae is a family of flowering trees sometimes included in the dogwood family (Cornaceae).

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Pictet–Spengler reaction

The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine such as tryptamine undergoes ring closure after condensation with an aldehyde or ketone.

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Quinine

Quinine is a medication used to treat malaria and babesiosis.

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Rubiaceae

The Rubiaceae are a family of flowering plants, commonly known as the coffee, madder, or bedstraw family.

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Saccharomyces cerevisiae

Saccharomyces cerevisiae is a species of yeast.

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Secologanin

Secologanin is a secoiridoid monoterpene synthesized from geranyl pyrophosphate in the mevalonate pathway.

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Serpentine (alkaloid)

Serpentine is a terpene indole alkaloid produced by several members of the Apocynaceae family, including Catharanthus roseus and Rauvolfia serpentina.

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Strictosidine synthase

Strictosidine synthase a key enzyme in alkaloid biosynthesis.

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Tryptamine

Tryptamine is a monoamine alkaloid.

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Vinblastine

Vinblastine is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer.

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Vincristine

Vincristine, also known as leurocristine and marketed under the brandname Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously. Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low blood white cells. It will likely cause harm to the baby if given during pregnancy. It works by stopping cells from dividing properly. Vincristine was first isolated in 1961. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is between 1.80 and 42.60 USD per dose. It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus.

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Redirects here:

C27H34N2O9, Isovincoside.

References

[1] https://en.wikipedia.org/wiki/Strictosidine

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