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Surfactant protein A1

Index Surfactant protein A1

Surfactant protein A1 (SP-A1), also known as Pulmonary surfactant-associated protein A1 (PSP-A) is a protein that in humans is encoded by the SFTPA1 gene. [1]

81 relations: Adaptive immune system, Allergen, Alveolar macrophage, Amino acid, Antigen, Antigen presentation, Asthma, Bacteria, Base pair, Birth, Carbohydrate, Cell growth, Cell surface receptor, Chemotaxis, Chromosome 10, Club cell, Coding region, Collectin, Cystic fibrosis, Cytokine, Dendritic cell, Epigenetics, Eukaryotic translation, Exhalation, Exon, Extracellular, Eye, Five prime untranslated region, Fungus, Gene, Gene (journal), Glucocorticoid, Haplotype, Homeostasis, Hormone, Idiopathic pulmonary fibrosis, Infant respiratory distress syndrome, Infection, Inflammation, Innate immune system, Large intestine, Lectin, Locus (genetics), Lung, Messenger RNA, Microorganism, MicroRNA, Monoclonal antibody, Monocyte, Neutrophil, ..., Nitric oxide, Nucleotide, Oligomer, Opsonin, Pancreas, Particulates, Pathogen, Phagocytosis, Preterm birth, Proinflammatory cytokine, Prostate, Protein, Protein splicing, Pulmonary alveolus, Pulmonary fibrosis, Pulmonary surfactant, Reactive oxygen species, Respiratory disease, Salivary gland, Shortness of breath, Single-nucleotide polymorphism, Start codon, Surface tension, Surfactant protein A, Surfactant protein A2, Thymus, Trachea, Transcription (biology), Translation (biology), Virus, White blood cell. Expand index (31 more) »

Adaptive immune system

The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth.

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Allergen

An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body.

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Alveolar macrophage

An alveolar macrophage (or dust cell) is a type of macrophage found in the pulmonary alveolus, near the pneumocytes, but separated from the wall.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Antigen

In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.

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Antigen presentation

Antigen presentation describes a vital immune process which is essential for T cell immune response triggering.

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Asthma

Asthma is a common long-term inflammatory disease of the airways of the lungs.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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Base pair

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.

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Birth

Birth is the act or process of bearing or bringing forth offspring.

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Carbohydrate

A carbohydrate is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water); in other words, with the empirical formula (where m may be different from n).

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Cell growth

The term cell growth is used in the contexts of biological cell development and cell division (reproduction).

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Cell surface receptor

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.

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Chemotaxis

Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.

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Chromosome 10

Chromosome 10 is one of the 23 pairs of chromosomes in humans.

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Club cell

Club cells, also known as bronchiolar exocrine cells, and originally known as Clara cells, are dome-shaped cells with short microvilli, found in the small airways (bronchioles) of the lungs.

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Coding region

The coding region of a gene, also known as the CDS (from CoDing Sequence), is that portion of a gene's DNA or RNA that codes for protein.

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Collectin

Collectins (collagen-containing C-type lectins) are a part of the innate immune system.

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Cystic fibrosis

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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Epigenetics

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

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Eukaryotic translation

Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes.

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Exhalation

Exhalation (or expiration) is the flow of the breath out of an organism.

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Exon

An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

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Extracellular

In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".

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Eye

Eyes are organs of the visual system.

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Five prime untranslated region

The 5′ untranslated region (5′ UTR) (also known as a leader sequence or leader RNA) is the region of an mRNA that is directly upstream from the initiation codon.

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Fungus

A fungus (plural: fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene (journal)

Gene is a peer-reviewed scientific journal in genetics, focusing on the cloning, structure, and function of genes.

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Glucocorticoid

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.

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Haplotype

A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent.

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Homeostasis

Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.

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Hormone

A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a type of chronic lung disease characterized by a progressive and irreversible decline in lung function.

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Infant respiratory distress syndrome

Infant respiratory distress syndrome (IRDS), also called neonatal respiratory distress syndrome (NRDS), respiratory distress syndrome of newborn, or increasingly surfactant deficiency disorder (SDD), and previously called hyaline membrane disease (HMD), is a syndrome in premature infants caused by developmental insufficiency of pulmonary surfactant production and structural immaturity in the lungs.

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Infection

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Innate immune system

The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.

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Large intestine

The large intestine, also known as the large bowel or colon, is the last part of the gastrointestinal tract and of the digestive system in vertebrates.

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Lectin

Lectins are carbohydrate-binding proteins, macromolecules that are highly specific for sugar moieties of other molecules.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Microorganism

A microorganism, or microbe, is a microscopic organism, which may exist in its single-celled form or in a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from 6th century BC India and the 1st century BC book On Agriculture by Marcus Terentius Varro. Microbiology, the scientific study of microorganisms, began with their observation under the microscope in the 1670s by Antonie van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera and anthrax. Microorganisms include all unicellular organisms and so are extremely diverse. Of the three domains of life identified by Carl Woese, all of the Archaea and Bacteria are microorganisms. These were previously grouped together in the two domain system as Prokaryotes, the other being the eukaryotes. The third domain Eukaryota includes all multicellular organisms and many unicellular protists and protozoans. Some protists are related to animals and some to green plants. Many of the multicellular organisms are microscopic, namely micro-animals, some fungi and some algae, but these are not discussed here. They live in almost every habitat from the poles to the equator, deserts, geysers, rocks and the deep sea. Some are adapted to extremes such as very hot or very cold conditions, others to high pressure and a few such as Deinococcus radiodurans to high radiation environments. Microorganisms also make up the microbiota found in and on all multicellular organisms. A December 2017 report stated that 3.45 billion year old Australian rocks once contained microorganisms, the earliest direct evidence of life on Earth. Microbes are important in human culture and health in many ways, serving to ferment foods, treat sewage, produce fuel, enzymes and other bioactive compounds. They are essential tools in biology as model organisms and have been put to use in biological warfare and bioterrorism. They are a vital component of fertile soils. In the human body microorganisms make up the human microbiota including the essential gut flora. They are the pathogens responsible for many infectious diseases and as such are the target of hygiene measures.

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MicroRNA

A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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Monocyte

Monocytes are a type of leukocyte, or white blood cell.

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Neutrophil

Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.

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Nitric oxide

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.

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Nucleotide

Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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Oligomer

An oligomer (oligo-, "a few" + -mer, "parts") is a molecular complex of chemicals that consists of a few monomer units, in contrast to a polymer, where the number of monomers is, in principle, infinite.

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Opsonin

An opsonin (from the Greek opsōneîn, to prepare for eating) is any molecule that enhances phagocytosis by marking an antigen for an immune response or marking dead cells for recycling (i.e., causes the phagocyte to "relish" the marked cell).

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Pancreas

The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates.

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Particulates

Atmospheric aerosol particles, also known as atmospheric particulate matter, particulate matter (PM), particulates, or suspended particulate matter (SPM) are microscopic solid or liquid matter suspended in Earth's atmosphere.

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Pathogen

In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.

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Phagocytosis

In cell biology, phagocytosis is the process by which a cell—often a phagocyte or a protist—engulfs a solid particle to form an internal compartment known as a phagosome.

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Preterm birth

Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.

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Proinflammatory cytokine

A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation.

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Prostate

The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein splicing

Protein splicing is an intramolecular reaction of a particular protein in which an internal protein segment (called an intein) is removed from a precursor protein with a ligation of C-terminal and N-terminal external proteins (called exteins) on both sides.

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Pulmonary alveolus

A pulmonary alveolus (plural: alveoli, from Latin alveolus, "little cavity") is a hollow cavity found in the lung parenchyma, and is the basic unit of ventilation.

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Pulmonary fibrosis

Pulmonary fibrosis (literally "scarring of the lungs") is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems.

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Pulmonary surfactant

Pulmonary surfactant is a surface-active lipoprotein complex (phospholipoprotein) formed by type II alveolar cells.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Respiratory disease

Respiratory disease is a medical term that encompasses pathological conditions affecting the organs and tissues that make gas exchange possible in higher organisms, and includes conditions of the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.

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Salivary gland

The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts.

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Shortness of breath

Shortness of breath, also known as dyspnea, is the feeling that one cannot breathe well enough.

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Single-nucleotide polymorphism

A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

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Start codon

The start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome.

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Surface tension

Surface tension is the elastic tendency of a fluid surface which makes it acquire the least surface area possible.

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Surfactant protein A

Surfactant protein A is an innate immune system collectin.

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Surfactant protein A2

Surfactant protein A2 (SP-A2), also known as Pulmonary surfactant-associated protein A2 (PSP-A2) is a protein that in humans is encoded by the SFTPA2 gene.

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Thymus

The thymus is a specialized primary lymphoid organ of the immune system.

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Trachea

The trachea, colloquially called the windpipe, is a cartilaginous tube that connects the pharynx and larynx to the lungs, allowing the passage of air, and so is present in almost all air-breathing animals with lungs.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Translation (biology)

In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.

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Virus

A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Redirects here:

COLEC4, Colec4, PSPA, Pspa, Pulmonary surfactant-associated protein A1, SFTP1, SFTPA1, SFTPA1 (gene), SP-A1, Sftp1, Sftpa1, Sp-a1.

References

[1] https://en.wikipedia.org/wiki/Surfactant_protein_A1

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