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Synthetic ion channels

Index Synthetic ion channels

Synthetic ion channels are de novo chemical compounds that insert into lipid bilayers, form pores, and allow ions to flow from one side to the other. [1]

45 relations: Activation energy, Alamethicin, Alkali metal, Ampere, Amphiphile, Antimicrobial peptides, Calixarene, Capacitance, Click chemistry, Colorimetry (chemical method), Cyclodextrin, Detergent, Dye, Electrolyte, Electrophysiology, Fluorescence spectroscopy, Gramicidin, Ion, Ion channel, Ionophore, Lipid bilayer, Macrocycle, Macroscopic scale, Markov chain, Membrane biology, Membrane protein, Model lipid bilayer, Mutagenesis, Nanotechnology, Ohm, Organic chemistry, Passive transport, Peer review, Peptide, Pore-forming toxin, Single-molecule experiment, Spectroscopy, Statistical ensemble (mathematical physics), Stochastic, Supramolecular chemistry, Tony James (chemist), Vesicle (biology and chemistry), Voltage clamp, Voltage-gated ion channel, Wild type.

Activation energy

In chemistry and physics, activation energy is the energy which must be available to a chemical or nuclear system with potential reactants to result in: a chemical reaction, nuclear reaction, or other various other physical phenomena.

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Alamethicin

Alamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride.

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Alkali metal

The alkali metals are a group (column) in the periodic table consisting of the chemical elements lithium (Li), sodium (Na), potassium (K),The symbols Na and K for sodium and potassium are derived from their Latin names, natrium and kalium; these are still the names for the elements in some languages, such as German and Russian.

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Ampere

The ampere (symbol: A), often shortened to "amp",SI supports only the use of symbols and deprecates the use of abbreviations for units.

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Amphiphile

An amphiphile (from the Greek αμφις, amphis: both and φιλíα, philia: love, friendship) is a chemical compound possessing both hydrophilic (water-loving, polar) and lipophilic (fat-loving) properties.

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Antimicrobial peptides

Antimicrobial peptides (AMPs), also called host defense peptides (HDPs) are part of the innate immune response found among all classes of life.

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Calixarene

A calixarene is a macrocycle or cyclic oligomer based on a hydroxyalkylation product of a phenol and an aldehyde.

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Capacitance

Capacitance is the ratio of the change in an electric charge in a system to the corresponding change in its electric potential.

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Click chemistry

In chemical synthesis, "click" chemistry is a class of biocompatible small molecule reactions commonly used in bioconjugation, allowing the joining of substrates of choice with specific biomolecules.

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Colorimetry (chemical method)

In physical and analytical chemistry, colorimetry or colourimetry is a technique "used to determine the concentration of colored compounds in solution." A colorimeter is a device used to test the concentration of a solution by measuring its absorbance of a specific wavelength of light (not to be confused with the tristimulus colorimeter used to measure colors in general).

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Cyclodextrin

Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclic oligosaccharides).

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Detergent

A detergent is a surfactant or a mixture of surfactants with cleaning properties in dilute solutions.

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Dye

A dye is a colored substance that has an affinity to the substrate to which it is being applied.

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Electrolyte

An electrolyte is a substance that produces an electrically conducting solution when dissolved in a polar solvent, such as water.

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Electrophysiology

Electrophysiology (from Greek ἥλεκτρον, ēlektron, "amber"; φύσις, physis, "nature, origin"; and -λογία, -logia) is the study of the electrical properties of biological cells and tissues.

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Fluorescence spectroscopy

Fluorescence spectroscopy (also known as fluorometry or spectrofluorometry) is a type of electromagnetic spectroscopy that analyzes fluorescence from a sample.

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Gramicidin

Gramicidin is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14%, respectively, all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramicidin D contains linear pentadecapeptides, that is chains made up of 15 amino acids.

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Ion

An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).

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Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.

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Ionophore

An ionophore is a chemical species that reversibly binds ions.

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Lipid bilayer

The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules.

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Macrocycle

Macrocycles are often described as a molecule containing twelve or more atoms with at least one large ring.

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Macroscopic scale

The macroscopic scale is the length scale on which objects or phenomena are large enough to be visible almost practically with the naked eye, without magnifying optical instruments.

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Markov chain

A Markov chain is "a stochastic model describing a sequence of possible events in which the probability of each event depends only on the state attained in the previous event".

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Membrane biology

Membrane biology is the study of the biological and physiochemical characteristics of membranes.

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Membrane protein

Membrane proteins are proteins that interact with, or are part of, biological membranes.

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Model lipid bilayer

A model lipid bilayer is any bilayer assembled in vitro, as opposed to the bilayer of natural cell membranes or covering various sub-cellular structures like the nucleus.

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Mutagenesis

Mutagenesis is a process by which the genetic information of an organism is changed, resulting in a mutation.

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Nanotechnology

Nanotechnology ("nanotech") is manipulation of matter on an atomic, molecular, and supramolecular scale.

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Ohm

The ohm (symbol: Ω) is the SI derived unit of electrical resistance, named after German physicist Georg Simon Ohm.

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Organic chemistry

Organic chemistry is a chemistry subdiscipline involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.

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Passive transport

Passive transport is a movement of ions and other atomic or molecular substances across cell membranes without need of energy input.

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Peer review

Peer review is the evaluation of work by one or more people of similar competence to the producers of the work (peers).

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Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Pore-forming toxin

Pore-forming proteins (PFTs, also known as pore-forming toxins) are protein exotoxins, usually produced by bacteria, such as C. septicum and S. aureus.

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Single-molecule experiment

A single-molecule experiment is an experiment that investigates the properties of individual molecules.

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Spectroscopy

Spectroscopy is the study of the interaction between matter and electromagnetic radiation.

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Statistical ensemble (mathematical physics)

In mathematical physics, especially as introduced into statistical mechanics and thermodynamics by J. Willard Gibbs in 1902, an ensemble (also statistical ensemble) is an idealization consisting of a large number of virtual copies (sometimes infinitely many) of a system, considered all at once, each of which represents a possible state that the real system might be in.

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Stochastic

The word stochastic is an adjective in English that describes something that was randomly determined.

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Supramolecular chemistry

file:Supramolecular Assembly Lehn.jpg |Self-Assembly of a Circular Double Helicate Cucurbituril gyroscope AngewChemIntEd 2002 v41 p275 hires.png|Host-guest complex within another host (cucurbit10uril) Rotaxane Crystal Structure EurJOrgChem page2565 year1998.png| Category:Chemistry.

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Tony James (chemist)

Tony D. James FRSC (born 7 October 1964) is a chemist who is currently Professor of Chemistry at the University of Bath and recipient of the Royal Society Wolfson Research Merit Award.

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Vesicle (biology and chemistry)

In cell biology, a vesicle is a small structure within a cell, or extracellular, consisting of fluid enclosed by a lipid bilayer.

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Voltage clamp

The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level.

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Voltage-gated ion channel

Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential near the channel.

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Wild type

Wild type (WT) refers to the phenotype of the typical form of a species as it occurs in nature.

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References

[1] https://en.wikipedia.org/wiki/Synthetic_ion_channels

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