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Talimogene laherparepvec

Index Talimogene laherparepvec

Talimogene laherparepvec is a biopharmaceutical drug to treat melanoma lesions that cannot be operated on; it is injected directly into the lesion. [1]

35 relations: Amgen, Anemia, Biopharmaceutical, Cellular stress response, Cellulitis, Checkpoint inhibitor, Common cold, Cytotoxic T cell, Deep vein thrombosis, Dendritic cell, Edema, European Medicines Agency, Food and Drug Administration, Genetic engineering, Granulocyte-macrophage colony-stimulating factor, Head and neck squamous-cell carcinoma, Herpes simplex virus, Immunodeficiency, Infected cell protein 34.5, Infected cell protein 47, Ipilimumab, Melanoma, Oncolytic adenovirus, Oncolytic herpes virus, Oncolytic virus, Pancreatic cancer, Pembrolizumab, Phases of clinical research, Soft-tissue sarcoma, Tachycardia, Translation (biology), University College London, Virotherapy, Vitiligo, Woburn, Massachusetts.

Amgen

Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California.

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Anemia

Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.

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Biopharmaceutical

A biopharmaceutical, also known as a biologic(al) medical product, biological, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.

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Cellular stress response

Cellular stress response is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature, exposure to toxins, and mechanical damage.

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Cellulitis

Cellulitis is a bacterial infection involving the inner layers of the skin.

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Checkpoint inhibitor

Checkpoint inhibitor therapy is a form of cancer treatment immunotherapy currently under research.

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Common cold

The common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory tract that primarily affects the nose.

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Cytotoxic T cell

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.

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Deep vein thrombosis

Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly the legs.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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Edema

Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.

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European Medicines Agency

The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Genetic engineering

Genetic engineering, also called genetic modification or genetic manipulation, is the direct manipulation of an organism's genes using biotechnology.

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Granulocyte-macrophage colony-stimulating factor

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.

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Head and neck squamous-cell carcinoma

Head and neck cancers are malignant neoplasms that arise in the head and region which comprises nasal cavity, paranasal sinuses, oral cavity, salivary glands, pharynx, and larynx.

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Herpes simplex virus

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the herpesvirus family, Herpesviridae, that infect humans.

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Immunodeficiency

Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent.

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Infected cell protein 34.5

Infected cell protein 34.5 also ICP-34.5 or ICP34.5 is a protein expressed by the ɣ34.5 gene in viruses such as herpes simplex virus; it blocks a cellular stress response to viral infection.

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Infected cell protein 47

Infected cell protein 47 also ICP-47 or ICP47 is a protein secreted by the viruses such as Herpes simplex virus and Cytomegalovirus that allows them to evade the human immune system's CD8 T-cell response.

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Ipilimumab

Ipilimumab (trade name Yervoy) is a monoclonal antibody that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system.

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Melanoma

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Oncolytic adenovirus

Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus.

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Oncolytic herpes virus

Many variants of herpes simplex virus have been considered for viral therapy of cancer; the early development of these was thoroughly reviewed in the journal Cancer Gene Therapy in 2002.

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Oncolytic virus

An oncolytic virus is a virus that preferentially infects and kills cancer cells.

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Pancreatic cancer

Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.

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Pembrolizumab

Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is a humanized antibody used in cancer immunotherapy.

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Phases of clinical research

The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment.

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Soft-tissue sarcoma

A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is sometimes applied to elements of the soft tissue that are not currently considered connective tissue.

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Tachycardia

Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.

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Translation (biology)

In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.

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University College London

University College London (UCL) is a public research university in London, England, and a constituent college of the federal University of London.

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Virotherapy

Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases.

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Vitiligo

Vitiligo is a long-term skin condition characterized by patches of the skin losing their pigment.

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Woburn, Massachusetts

Woburn is a city in Middlesex County, Massachusetts, United States.

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Redirects here:

Biovex, Imlygic, OncoVEX GM-CSF, OncoVEXGM-CSF, Oncovex, T-VEC, TVEC.

References

[1] https://en.wikipedia.org/wiki/Talimogene_laherparepvec

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