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TBR1

Index TBR1

T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. [1]

71 relations: Alzheimer's disease, Amino acid, Amyloid precursor protein, Autism, Axon, Basal forebrain, Brachyury, C-terminus, Cajal–Retzius cell, CASK, Cellular differentiation, Cerebral cortex, Cerebrum, Cholinergic, Chromosome 2, Coactivator (genetics), Cocaine, Complementary DNA, Corticospinal tract, DNA-binding domain, DOT1L, Embryo, Eomesodermin, Evolution, Exon, Extracellular matrix, Forebrain, G0 phase, Gamma-Aminobutyric acid, Gene, Glutamic acid, GRIN2B, Guanylate kinase, Hippocampus, Homology (biology), Immune system, Immunohistochemistry, Intellectual disability, Interleukin-7 receptor, Lancelet, Lateral hypothalamus, Long-term potentiation, Medulloblastoma, Mesoderm, Methyltransferase, Neocortex, Neuron, Neurotransmitter, NMDA receptor, Olfactory bulb, ..., Pallium, Pallium (neuroanatomy), Parkinson's disease, PAX6, Placenta, Progenitor cell, Promoter (genetics), Protein, Pyramidal cell, Radial glial cell, Reelin, Repressor, RNA polymerase II, SOX5, Stem cell, T-box, TBX21, Transcription factor, University of California, San Francisco, Xenopus, Zebrafish. Expand index (21 more) »

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Amyloid precursor protein

Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons.

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Autism

Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.

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Axon

An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.

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Basal forebrain

The basal forebrain structures are located in the forebrain to the front of and below the striatum.

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Brachyury

Brachyury is a protein that in humans is encoded by the T gene.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cajal–Retzius cell

Cajal–Retzius cells (CR cells) (also known as Horizontal cells of Cajal) are a heterogeneous population of morphologically and molecularly distinct reelin-producing cell types in the marginal zone/layer I of the developmental cerebral cortex and in the immature hippocampus of different species and at different times during embryogenesis and postnatal life.

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CASK

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Cerebral cortex

The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.

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Cerebrum

The cerebrum is a large part of the brain containing the cerebral cortex (of the two cerebral hemispheres), as well as several subcortical structures, including the hippocampus, basal ganglia, and olfactory bulb.

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Cholinergic

In general, the word choline refers to the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation.

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Chromosome 2

Chromosome 2 is one of the 23 pairs of chromosomes in humans.

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Coactivator (genetics)

A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.

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Cocaine

Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.

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Complementary DNA

In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.

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Corticospinal tract

The corticospinal tract is a white matter motor pathway starting at the cerebral cortex that terminates on lower motor neurons and interneurons in the spinal cord, controlling movements of the limbs and trunk.

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DNA-binding domain

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.

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DOT1L

DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

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Embryo

An embryo is an early stage of development of a multicellular diploid eukaryotic organism.

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Eomesodermin

Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene.

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Evolution

Evolution is change in the heritable characteristics of biological populations over successive generations.

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Exon

An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

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Extracellular matrix

In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.

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Forebrain

In the anatomy of the brain of vertebrates, the forebrain or prosencephalon is the rostral-most (forward-most) portion of the brain.

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G0 phase

The G0 phase describes a cellular state outside of the replicative cell cycle.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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GRIN2B

Glutamate receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene.

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Guanylate kinase

In enzymology, a guanylate kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP.

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Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

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Homology (biology)

In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Immunohistochemistry

Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.

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Intellectual disability

Intellectual disability (ID), also known as general learning disability, and mental retardation (MR), is a generalized neurodevelopmental disorder characterized by significantly impaired intellectual and adaptive functioning.

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Interleukin-7 receptor

The interleukin-7 receptor is a protein found on the surface of cells.

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Lancelet

The lancelets — also known as amphioxi (singular, amphioxus) consist of about 32 species of fish-like marine chordates in the order Amphioxiformes.

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Lateral hypothalamus

The lateral hypothalamus, also called the lateral hypothalamic area, contains the primary orexinergic nucleus within the hypothalamus that widely projects throughout the nervous system; this system of neurons mediates an array of cognitive and physical processes, such as promoting feeding behavior and arousal, reducing pain perception, and regulating body temperature, digestive functions, and blood pressure, among many others.

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Long-term potentiation

In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity.

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Medulloblastoma

Medulloblastoma is the most common type of pediatric malignant primary brain tumor (cancer), originating in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa.

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Mesoderm

In all bilaterian animals, the mesoderm is one of the three primary germ layers in the very early embryo.

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Methyltransferase

Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features.

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Neocortex

The neocortex, also called the neopallium and isocortex, is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language.

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Neuron

A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.

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Olfactory bulb

The olfactory bulb (bulbus olfactorius) is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell.

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Pallium

The pallium (derived from the Roman pallium or palla, a woolen cloak;: pallia) is an ecclesiastical vestment in the Roman Catholic Church, originally peculiar to the Pope, but for many centuries bestowed by him on metropolitans and primates as a symbol of the jurisdiction delegated to them by the Holy See.

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Pallium (neuroanatomy)

In neuroanatomy, pallium refers to the layers of grey and white matter that cover the upper surface of the cerebrum in vertebrates.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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PAX6

Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene.

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Placenta

The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.

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Progenitor cell

A progenitor cell is a biological cell that, like a stem cell, has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its "target" cell.

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Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Pyramidal cell

Pyramidal cells, or (pyramidal neurons), are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala.

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Radial glial cell

Radial glial cells are bipolar-shaped cells that span the width of the cortex in the developing vertebrate central nervous system (CNS) and serve as primary progenitor cells capable of generating neurons, astrocytes, and oligodendrocytes.

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Reelin

Reelin (RELN) is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell-cell interactions.

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Repressor

In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers.

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RNA polymerase II

RNA polymerase II (RNAP II and Pol II) is a multiprotein complex.

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SOX5

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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T-box

T-box refers to a group of transcription factors involved in limb and heart development.

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TBX21

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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University of California, San Francisco

The University of California, San Francisco (UCSF), is a research university located in San Francisco, California and part of the University of California system.

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Xenopus

Xenopus (Gk., ξενος, xenos.

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Zebrafish

The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.

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Redirects here:

MGC141978, T-Brain 1, T-box, brain, 1, TBR-1, TBR1 (gene), TES-56.

References

[1] https://en.wikipedia.org/wiki/TBR1

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