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Large granular lymphocytic leukemia

Index Large granular lymphocytic leukemia

Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. [1]

34 relations: Alemtuzumab, Anemia, B symptoms, B3GAT1, Blood, Bone marrow, CD3 (immunology), CD4, CD8, Extracellular fluid, Felty's syndrome, Fred Hutchinson Cancer Research Center, Granzyme B, Hypoplasia, Immunophenotyping, Infection, Integrin alpha M, Leukemia, Liver, Lymphocyte, Lymphocytosis, Neural cell adhesion molecule, Nodule (medicine), Perforin, Red blood cell, Rheumatoid arthritis, Spleen, Splenomegaly, T cell, T-cell prolymphocytic leukemia, T-cell receptor, Thomas P. Loughran Jr., TIA1, University of Virginia.

Alemtuzumab

Alemtuzumab is a drug used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma under the trade names Campath, MabCampath and Campath-1H, and in the treatment of multiple sclerosis as Lemtrada.

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Anemia

Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.

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B symptoms

B symptoms refer to systemic symptoms of fever, night sweats, and weight loss which can be associated with both Hodgkin's lymphoma and non-Hodgkin's lymphoma.

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B3GAT1

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins.

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Blood

Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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CD3 (immunology)

In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).

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CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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CD8

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR).

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Extracellular fluid

Extracellular fluid (ECF) denotes all body fluid outside the cells.

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Felty's syndrome

Felty's syndrome, also called Felty syndrome, (FS) is rare autoimmune disease characterized by the triad of rheumatoid arthritis, splenomegaly and neutropenia.

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Fred Hutchinson Cancer Research Center

The Fred Hutchinson Cancer Research Center, also known as Fred Hutch or The Hutch, is a cancer research institute established in 1972 in Seattle, Washington.

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Granzyme B

Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs), natural killer cells (NK cells) and cytotoxic T cells.

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Hypoplasia

Hypoplasia (from Ancient Greek ὑπo- hypo-, "under" + πλάσις plasis, "formation"; adjective form hypoplastic) is underdevelopment or incomplete development of a tissue or organ.

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Immunophenotyping

Immunophenotyping is a technique used to study the protein expressed by cells.

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Infection

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.

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Integrin alpha M

Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3).

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Leukemia

Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Lymphocytosis

Lymphocytosis is an increase in the number of lymphocytes in the blood.

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Neural cell adhesion molecule

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle.

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Nodule (medicine)

In medicine, nodules are solid, elevated areas of tissue or fluid inside or under the skin with a diameter greater than 0.5 centimeters.

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Perforin

Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Rheumatoid arthritis

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.

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Spleen

The spleen is an organ found in virtually all vertebrates.

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Splenomegaly

Splenomegaly is an enlargement of the spleen.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T-cell prolymphocytic leukemia

T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin involvement.

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T-cell receptor

The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

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Thomas P. Loughran Jr.

Thomas P. Loughran, Jr. is an American physician-scientist who specializes in cancer research and treatment.

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TIA1

TIA1 is a 3'UTR mRNA binding protein that can bind the 5'TOP sequence of 5'TOP mRNAs.

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University of Virginia

The University of Virginia (U.Va. or UVA), frequently referred to simply as Virginia, is a public research university and the flagship for the Commonwealth of Virginia.

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Redirects here:

T-cell large granular lymphocyte leukemia, T-cell large granular lymphocytic leukemia.

References

[1] https://en.wikipedia.org/wiki/Large_granular_lymphocytic_leukemia

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