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T-cell lymphoma invasion and metastasis-inducing protein 1

Index T-cell lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene. [1]

22 relations: ANK1, BAIAP2, Carcinoma, CDC42, Cingulin, Gene, Immortalised cell line, Lymphoma, Melanoma, Myc, Neoplasm, Neuroblastoma, PDZ domain, Pleckstrin homology domain, PPP1R9B, Protein, Protein–protein interaction, RAC1, RAC2, Rho family of GTPases, RHOA, RhoGEF domain.

ANK1

Ankyrin 1, erythrocytic, also known as ANK1, is a protein that in humans is encoded by the ANK1 gene.

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BAIAP2

Brain-specific angiogenesis inhibitor 1-associated protein 2 is a protein that in humans is encoded by the BAIAP2 gene.

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Carcinoma

Carcinoma is a type of cancer that develops from epithelial cells.

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CDC42

Cell division control protein 42 homolog, also known as Cdc42, is a protein involved in regulation of the cell cycle.

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Cingulin

Cingulin (CGN; from the Latin cingere “to form a belt around”) is a cytosolic protein encoded by the CGN gene in humans localized at tight junctions (TJs) of vertebrate epithelial and endothelial cells.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Immortalised cell line

An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Melanoma

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Neuroblastoma

Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands, but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Occasionally, neuroblastoma may be due to a mutation inherited from a person's parents. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiation, chemotherapy, or stem cell transplantation. Low-risk disease in babies typically has a good outcome with surgery or simply observation. In high-risk disease, chances of long-term survival, however, are less than 40% despite aggressive treatment. Neuroblastoma is the most common cancer in babies and the third-most common cancer in children after leukemia and brain cancer. About one in every 7,000 children is affected at some time. About 90% of cases occur in children less than 5 years old and it is rare in adults. Of cancer deaths in children, about 15% are due to neuroblastoma. The disease was first described in the 1800s.

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PDZ domain

The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals.

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Pleckstrin homology domain

Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.

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PPP1R9B

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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RAC1

Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells.

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RAC2

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.

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Rho family of GTPases

The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily.

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RHOA

Ras homolog gene family, member A (RhoA) is a small GTPase protein in the Rho family.

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RhoGEF domain

RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases.

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Redirects here:

TIAM1, TIAM1 (gene).

References

[1] https://en.wikipedia.org/wiki/T-cell_lymphoma_invasion_and_metastasis-inducing_protein_1

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