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T-cell prolymphocytic leukemia

Index T-cell prolymphocytic leukemia

T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin involvement. [1]

45 relations: Alemtuzumab, Anemia, Antibody, Basophilic, Blood, Bone marrow, CD1, CD2, CD3 (immunology), CD4, CD7, CD8, Cell nucleus, Chemotherapy regimen, Chlorambucil, CHOP, Chromosome 14, Chromosome 8, Cytoplasm, Dermis, Hematopoietic stem cell transplantation, Hepatosplenomegaly, Human T-lymphotropic virus 1, Immunophenotyping, Leukemia, Liver, Lymph node, Lymphadenopathy, Lymphocyte, Monoclonal antibody, Myeloma protein, Neoplasm, Nucleolus, Prolymphocyte, Purine analogue, Red pulp, Sézary disease, Skin, Spleen, T cell, Terminal deoxynucleotidyl transferase, Thrombocytopenia, Thymus, Trisomy 8, White pulp.

Alemtuzumab

Alemtuzumab is a drug used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma under the trade names Campath, MabCampath and Campath-1H, and in the treatment of multiple sclerosis as Lemtrada.

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Anemia

Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Basophilic

Basophilic is a technical term used by histologists.

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Blood

Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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CD1

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

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CD2

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells.

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CD3 (immunology)

In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).

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CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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CD7

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.

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CD8

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR).

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Chemotherapy regimen

A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.

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Chlorambucil

Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma.

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CHOP

CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma.

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Chromosome 14

Chromosome 14 is one of the 23 pairs of chromosomes in humans.

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Chromosome 8

Chromosome 8 is one of the 23 pairs of chromosomes in humans.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Dermis

The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain.

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Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.

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Hepatosplenomegaly

Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).

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Human T-lymphotropic virus 1

Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases.

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Immunophenotyping

Immunophenotyping is a technique used to study the protein expressed by cells.

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Leukemia

Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Lymphadenopathy

Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number, or consistency.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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Myeloma protein

A myeloma protein is an abnormal immunoglobulin fragment, such as an immunoglobulin light chain, that is produced in excess by an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Nucleolus

The nucleolus (plural nucleoli) is the largest structure in the nucleus of eukaryotic cells.

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Prolymphocyte

A prolymphocyte is a white blood cell with a certain state of cellular differentiation in lymphocytopoiesis.

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Purine analogue

Purine analogues are antimetabolites that mimic the structure of metabolic purines.

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Red pulp

The red pulp of the spleen is composed of connective tissue known also as the cords of Billroth and many splenic sinuses that are engorged with blood, giving it a red color.

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Sézary disease

Sézary disease is a type of cutaneous lymphoma that was first described by Albert Sézary.

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Skin

Skin is the soft outer tissue covering vertebrates.

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Spleen

The spleen is an organ found in virtually all vertebrates.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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Terminal deoxynucleotidyl transferase

Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells.

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Thrombocytopenia

Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.

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Thymus

The thymus is a specialized primary lymphoid organ of the immune system.

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Trisomy 8

Trisomy 8, also known as Warkany syndrome 2, is a human chromosomal disorder caused by having three copies (trisomy) of chromosome 8.

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White pulp

White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on gross section), that encompasses approximately 25% of splenic tissue.

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Redirects here:

Leukemia, T-Cell, chronic, Prolymphocytic leukemia, T-cell type, T-PLL.

References

[1] https://en.wikipedia.org/wiki/T-cell_prolymphocytic_leukemia

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