41 relations: Absence seizure, Angiotensin, Antagonist, Basal ganglia, CACNA1G, CACNA1H, CACNA1I, Calcium, Calcium channel blocker, Cancer, Cancer stem cell, Cell cycle, Clinical trial, Cytostasis, Cytotoxicity, Depolarization, Dopamine, GAERS, Glioma, Insulinoma, L-type calcium channel, Leukemia, Levodopa-induced dyskinesia, Melanoma, Mibefradil, Neuropathic pain, Neuroplasticity, Neurotransmission, Pain, Parkinson's disease, Potassium, Retinoblastoma, Sinoatrial node, Sodium, Sodium channel, Sympathetic nervous system, Thalamic reticular nucleus, Thalamus, Visceral pain, Voltage-gated calcium channel, Voltage-gated ion channel.
Absence seizures are one of several kinds of generalized seizures.
Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure.
An antagonist is a character, group of characters, institution or concept that stands in or represents opposition against which the protagonist(s) must contend.
The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.
Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene.
Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the CACNA1H gene.
Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene.
Calcium is a chemical element with symbol Ca and atomic number 20.
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium through calcium channels.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample.
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
Clinical trials are experiments or observations done in clinical research.
Cytostasis (cyto – cell; stasis – stoppage) is the inhibition of cell growth and multiplication.
Cytotoxicity is the quality of being toxic to cells.
In biology, depolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell.
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
The GAERS or Genetic Absence Epilepsy Rat from Strasbourg is a recognized animal model of absence epilepsy, a typical childhood form of epilepsy characterized by recurrent loss of contact and concomitant pattern on the electroencephalogram called "spike-and-wave" discharges.
A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin.
The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel.
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
Levodopa-induced dyskinesia is a form of dyskinesia associated with levodopa, used to treat Parkinson's disease.
Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.
Mibefradil (Posicor) is a drug for the treatment of hypertension and chronic angina pectoris.
Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system.
Neuroplasticity, also known as brain plasticity and neural plasticity, is the ability of the brain to change throughout an individual's life, e.g., brain activity associated with a given function can be transferred to a different location, the proportion of grey matter can change, and synapses may strengthen or weaken over time.
Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).
Pain is a distressing feeling often caused by intense or damaging stimuli.
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
Potassium is a chemical element with symbol K (from Neo-Latin kalium) and atomic number 19.
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye.
The sinoatrial node (SA node), also known as sinus node, is a group of cells located in the wall of the right atrium of the heart.
Sodium is a chemical element with symbol Na (from Latin natrium) and atomic number 11.
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the parasympathetic nervous system.
The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally.
The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.
Visceral pain is pain that results from the activation of nociceptors of the thoracic, pelvic, or abdominal viscera (organs).
Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the calcium ion Ca2+.
Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential near the channel.