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TBC domain

Index TBC domain

The TBC (Tre-2/Bub2/Cdc16) is identified as a domain of some proteins or as a protein motif and widely recognized as a conserved one that includes approximately 200 amino acids in all eukaryotes. [1]

45 relations: Amino acid, Analysis, Cancer, Cell (biology), Cell membrane, Clade, Disease, Effector (biology), Eukaryote, Evolution, G protein, Gene, Genome, Glucose, GLUT4, GRAM domain, GTPase, GTPase-activating protein, Guanosine diphosphate, Guanosine triphosphate, Human, In vitro, Insulin, Interaction, Mammal, Membrane transport, Membrane vesicle trafficking, Molecule, Organelle, Overweight, Phosphotyrosine-binding domain, Phylogenetics, Protein, Protein domain, Rab (G-protein), RAB5A, Regulator gene, RUN domain, Scientific method, Signal transduction, Structural motif, Target protein, TBC1D1, TBC1D4, Vesicle (biology and chemistry).

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Analysis

Analysis is the process of breaking a complex topic or substance into smaller parts in order to gain a better understanding of it.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).

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Clade

A clade (from κλάδος, klados, "branch"), also known as monophyletic group, is a group of organisms that consists of a common ancestor and all its lineal descendants, and represents a single "branch" on the "tree of life".

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Disease

A disease is any condition which results in the disorder of a structure or function in an organism that is not due to any external injury.

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Effector (biology)

In biochemistry, an effector molecule is usually a small molecule that selectively binds to a protein and regulates its biological activity.

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Eukaryote

Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).

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Evolution

Evolution is change in the heritable characteristics of biological populations over successive generations.

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G protein

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Genome

In the fields of molecular biology and genetics, a genome is the genetic material of an organism.

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Glucose

Glucose is a simple sugar with the molecular formula C6H12O6.

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GLUT4

Glucose transporter type 4 (GLUT-4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene.

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GRAM domain

The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins.

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GTPase

GTPases (singular GTPase) are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP).

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GTPase-activating protein

GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event.

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Guanosine diphosphate

Guanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate.

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Guanosine triphosphate

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate.

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Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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Insulin

Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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Interaction

Interaction is a kind of action that occur as two or more objects have an effect upon one another.

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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Membrane transport

In cellular biology, membrane transport refers to the collection of mechanisms that regulate the passage of solutes such as ions and small molecules through biological membranes, which are lipid bilayers that contain proteins embedded in them.

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Membrane vesicle trafficking

Membrane vesicle trafficking in eukaryotic animal cells involves movement of important biochemical signal molecules from synthesis-and-packaging locations in the Golgi body to specific 'release' locations on the inside of the plasma membrane of the secretory cell, in the form of Golgi membrane-bound micro-sized vesicles, termed membrane vesicles (MVs).

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Molecule

A molecule is an electrically neutral group of two or more atoms held together by chemical bonds.

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Organelle

In cell biology, an organelle is a specialized subunit within a cell that has a specific function, in which their function is vital for the cell to live.

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Overweight

Being overweight or fat is having more body fat than is optimally healthy.

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Phosphotyrosine-binding domain

In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine.

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Phylogenetics

In biology, phylogenetics (Greek: φυλή, φῦλον – phylé, phylon.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Rab (G-protein)

The Rab family of proteins is a member of the Ras superfamily of monomeric G proteins.

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RAB5A

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.

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Regulator gene

A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes.

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RUN domain

The RUN domain is an evolutionary conserved protein–protein binding protein domain.

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Scientific method

Scientific method is an empirical method of knowledge acquisition, which has characterized the development of natural science since at least the 17th century, involving careful observation, which includes rigorous skepticism about what one observes, given that cognitive assumptions about how the world works influence how one interprets a percept; formulating hypotheses, via induction, based on such observations; experimental testing and measurement of deductions drawn from the hypotheses; and refinement (or elimination) of the hypotheses based on the experimental findings.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.

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Target protein

Target proteins are functional biomolecules that are addressed and controlled by biologically active compounds.

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TBC1D1

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.

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TBC1D4

AS160 (Akt substrate of 160 kDa), which was originally known as TBC1 domain family member 4 (TBC1D4), is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene.

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Vesicle (biology and chemistry)

In cell biology, a vesicle is a small structure within a cell, or extracellular, consisting of fluid enclosed by a lipid bilayer.

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References

[1] https://en.wikipedia.org/wiki/TBC_domain

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