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TGFβ superfamily receptor

Index TGFβ superfamily receptor

The Transforming Growth Factor beta (TGFβ) receptors are a superfamily of serine/threonine kinase receptors. [1]

28 relations: Activin and inhibin, ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone, BMPR1A, BMPR1B, BMPR2, Bone morphogenetic protein, Cell signaling, Cytokine, Growth differentiation factor, Growth factor, Myostatin, NODAL, Protein superfamily, Receptor protein serine/threonine kinase, TGF beta 1, TGF beta 2, TGF beta receptor, TGF beta receptor 1, TGF beta receptor 2, TGFBR3, Transforming growth factor beta, Transforming growth factor, beta 3.

Activin and inhibin

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects.

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ACVR1

Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin receptor-like kinase-2).

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ACVR1B

Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene.

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ACVR1C

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.

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ACVR2A

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene.

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ACVR2B

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.

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ACVRL1

Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene.

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Anti-Müllerian hormone

Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from the transforming growth factor beta superfamily, whose key roles are in growth differentiation and folliculogenesis.

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BMPR1A

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene.

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BMPR1B

Bone morphogenetic protein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans is encoded by the BMPR1B gene.

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BMPR2

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase.

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Bone morphogenetic protein

Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens.

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Growth differentiation factor

Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development.

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Growth factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.

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Myostatin

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation.

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NODAL

Nodal is a secretory protein that in humans is encoded by the NODAL gene which is located on chromosome 10q22.1.

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Protein superfamily

A protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology).

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Receptor protein serine/threonine kinase

In enzymology, a receptor protein serine/threonine kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and receptor protein, whereas its two products are ADP and receptor protein phosphate.

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TGF beta 1

Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines.

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TGF beta 2

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin).

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TGF beta receptor

Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors.

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TGF beta receptor 1

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound receptor protein for the TGF beta superfamily of signaling ligands.

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TGF beta receptor 2

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor.

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TGFBR3

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight.

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Transforming growth factor beta

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.

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Transforming growth factor, beta 3

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.

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References

[1] https://en.wikipedia.org/wiki/TGFβ_superfamily_receptor

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