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36 relations: Apoptosis, Azole, Bis(2-ethylhexyl) phthalate, Chemotherapy, Cyclophosphamide, Cytotoxicity, Dimethylacetamide, Doxorubicin, Erlotinib, Ethanol, FOLFIRINOX, Gemcitabine, Glucose, Hypoxia (medical), Hypoxia-activated prodrug, Ifosfamide, International nonproprietary name, Mechanism of action, Merck Group, Pancreatic cancer, Pharmaceutical formulation, Polysorbate 80, Polyvinyl chloride, Prodrug, Progression-free survival, Protein-bound paclitaxel, Reimbursement, Response evaluation criteria in solid tumors, Soft-tissue sarcoma, Stefan Oschmann, Structure–activity relationship, Superoxide, Survival rate, Tumor hypoxia, United States Adopted Name, Water for injection.
Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Azole
Azoles are a class of five-membered heterocyclic compounds containing a nitrogen atom and at least one other non-carbon atom (i.e. nitrogen, sulfur, or oxygen) as part of the ring.
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Bis(2-ethylhexyl) phthalate
Bis(2-ethylhexyl) phthalate (di-2-ethylhexyl phthalate, diethylhexyl phthalate, DEHP; dioctyl phthalate, DOP) is an organic compound with the formula C6H4(CO2C8H17)2.
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
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Cyclophosphamide
Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.
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Cytotoxicity
Cytotoxicity is the quality of being toxic to cells.
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Dimethylacetamide
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2.
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Doxorubicin
Doxorubicin, sold under the trade names Adriamycin among others, is a chemotherapy medication used to treat cancer.
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Erlotinib
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer.
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Ethanol
Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.
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FOLFIRINOX
FOLFIRINOX is a chemotherapy regimen for treatment of advanced pancreatic cancer.
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Gemcitabine
Gemcitabine, sold under the brand name Gemzar, among others, is a chemotherapy medication used to treat a number of types of cancer.
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Glucose
Glucose is a simple sugar with the molecular formula C6H12O6.
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Hypoxia (medical)
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.
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Hypoxia-activated prodrug
Hypoxia-Activated Prodrugs (HAPs) are prodrugs that target regions of tumor hypoxia within tumor cells.
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Ifosfamide
Ifosfamide (IFO), sold under the brand name Ifex among others, is a chemotherapy medication used to treat a number of types of cancer.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
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Merck Group
Merck KGaA, branded and commonly known as Merck, is a German multinational pharmaceutical, chemical and life sciences company headquartered in Darmstadt, with around 50,000 employees in around 70 countries.
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Pancreatic cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.
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Pharmaceutical formulation
Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product.
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Polysorbate 80
Polysorbate 80 is a nonionic surfactant and emulsifier often used in foods and cosmetics.
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Polyvinyl chloride
Polyvinyl chloride, also known as polyvinyl or '''vinyl''', commonly abbreviated PVC, is the world's third-most widely produced synthetic plastic polymer, after polyethylene and polypropylene.
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Prodrug
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Progression-free survival
Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse".
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Protein-bound paclitaxel
Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others.
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Reimbursement
Reimbursement is the act of compensating someone for an out-of-pocket expense by giving them an amount of money equal to what was spent.
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Response evaluation criteria in solid tumors
Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve ("respond"), stay the same ("stabilize"), or worsen ("progress") during treatment.
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Soft-tissue sarcoma
A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is sometimes applied to elements of the soft tissue that are not currently considered connective tissue.
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Stefan Oschmann
Stefan Oschmann (born 25 July 1957) is a German businessman, who has served as the chief executive officer (CEO) and chairman of the executive board of the Germany-based Merck Group since April 2016.
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Structure–activity relationship
commented out as it doesn't appear to be immediately relevant & it is in the wrong place if it is relevant-->The structure–activity relationship (SAR) is the relationship between the chemical or 3D structure of a molecule and its biological activity.
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Superoxide
A superoxide is a compound that contains the superoxide anion, which has the chemical formula.
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Survival rate
Survival rate is a part of survival analysis.
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Tumor hypoxia
Tumor hypoxia is the situation where tumor cells have been deprived of oxygen.
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United States Adopted Name
United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.
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Water for injection
Water for injection is water of extra high quality without significant contamination.
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Redirects here:
C9H16Br2N5O4P, HAP-302, TH-302.
References
[1] https://en.wikipedia.org/wiki/Evofosfamide
