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Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene. [1]

33 relations: Aggression, Alzheimer's disease, Beta cell, Biopterin, Brain, Case-control study, Decarboxylation, Enterochromaffin cell, Gene, Impulsivity, Indolamines, Intron, Isozyme, Mast cell, Melatonin, Mental disorder, N,N-Dimethyltryptamine, N-Methyltryptamine, Pinealocyte, Polymorphism (biology), Raphe nuclei, Rs1799913, Rs1800532, Serotonin, TPH2, Trait theory, Transcription (biology), Translation (biology), Tryptamine, Tryptophan, Tryptophan hydroxylase, White blood cell, 5-Hydroxytryptophan.


Aggression is overt, often harmful, social interaction with the intention of inflicting damage or other unpleasantness upon another individual.

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Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Beta cell

Beta cells (β cells) are a type of cell found in the pancreatic islets of the pancreas.

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Biopterins are pterin derivatives which function as endogenous enzyme cofactors in many species of animals and in some bacteria and fungi.

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The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

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Case-control study

A case-control study is a type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causal attribute.

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Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).

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Enterochromaffin cell

Enterochromaffin (EC) cells (also known as Kulchitsky cells), discovered by Nikolai Kulchitsky of Karazin Kharkiv National University.

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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In psychology, impulsivity (or impulsiveness) is a tendency to act on a whim, displaying behavior characterized by little or no forethought, reflection, or consideration of the consequences.

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Indolamines are a family of neurotransmitters that share a common molecular structure (namely, indolamine).

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An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.

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Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.

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Mast cell

A mast cell (also known as a mastocyte or a labrocyte) is a type of white blood cell.

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Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness.

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Mental disorder

A mental disorder, also called a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.

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N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.

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N-Methyltryptamine (NMT) is a member of the substituted tryptamine chemical class and a natural product which is biosynthesized in the human body from tryptamine by certain N-methyltransferase enzymes, such as indolethylamine ''N''-methyltransferase.

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Pinealocytes are the main cells contained in the pineal gland, located behind the third ventricle and between the two hemispheres of the brain.

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Polymorphism (biology)

Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

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Raphe nuclei

The raphe nuclei (ῥαφή "seam"Liddell, H.G. & Scott, R. (1940). A Greek-English Lexicon. revised and augmented throughout by Sir Henry Stuart Jones. with the assistance of. Roderick McKenzie. Oxford: Clarendon Press.) are a moderate-size cluster of nuclei found in the brain stem.

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In genetics, rs1799913, also called A779C, is a gene variation—a single nucleotide polymorphism (SNP)— in the TPH1 gene.

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In genetics, rs1800532 (A218C) is a genetic variant.

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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates.

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Trait theory

In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Translation (biology)

In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.

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Tryptamine is a monoamine alkaloid.

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Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins.

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Tryptophan hydroxylase

Tryptophan hydroxylase (TPH) is an enzyme involved in the synthesis of the neurotransmitter serotonin.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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5-Hydroxytryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.

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TPH1 (gene), Tryptophan hydroxylase 1.


[1] https://en.wikipedia.org/wiki/TPH1

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