Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Androidâ„¢ device!
Free
Faster access than browser!
 

T cell receptor revision

Index T cell receptor revision

T cell receptor revision (alternative term: antigen receptor editing) is a process in the peripheral immune system which is used by mature T cells to alter their original antigenic specificity based on rearranged T cell receptors (TCR). [1]

20 relations: Antigen, Autoimmunity, Central tolerance, Complementarity-determining region, Gamma delta T cell, Gene conversion, Gene knock-in, Genetic recombination, Genetically modified organism, Major histocompatibility complex, Peripheral tolerance, RAG1, RAG2, Receptor editing, Regulatory T cell, T cell, T helper 17 cell, T-cell receptor, Thymus, V(D)J recombination.

Antigen

In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.

New!!: T cell receptor revision and Antigen · See more »

Autoimmunity

Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues.

New!!: T cell receptor revision and Autoimmunity · See more »

Central tolerance

Central tolerance, also known as negative selection, is the process of eliminating any developing T or B lymphocytes that are reactive to self.

New!!: T cell receptor revision and Central tolerance · See more »

Complementarity-determining region

Complementarity-determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules bind to their specific antigen.

New!!: T cell receptor revision and Complementarity-determining region · See more »

Gamma delta T cell

Gamma delta T cells (γδ T cells) are T cells that have a distinctive T-cell receptor (TCR) on their surface.

New!!: T cell receptor revision and Gamma delta T cell · See more »

Gene conversion

Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion event.

New!!: T cell receptor revision and Gene conversion · See more »

Gene knock-in

In molecular cloning and biology, a knock-in (or gene knock-in) refers to a genetic engineering method that involves the one-for-one substitution of DNA sequence information in a genetic locus or the insertion of sequence information not found within the locus.

New!!: T cell receptor revision and Gene knock-in · See more »

Genetic recombination

Genetic recombination (aka genetic reshuffling) is the production of offspring with combinations of traits that differ from those found in either parent.

New!!: T cell receptor revision and Genetic recombination · See more »

Genetically modified organism

A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques (i.e., a genetically engineered organism).

New!!: T cell receptor revision and Genetically modified organism · See more »

Major histocompatibility complex

The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.

New!!: T cell receptor revision and Major histocompatibility complex · See more »

Peripheral tolerance

Peripheral tolerance is the second branch of immunological tolerance, after central tolerance.

New!!: T cell receptor revision and Peripheral tolerance · See more »

RAG1

Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.

New!!: T cell receptor revision and RAG1 · See more »

RAG2

Recombination activating gene 2 also known as RAG-2 is a protein that in humans is encoded by the RAG2 gene.

New!!: T cell receptor revision and RAG2 · See more »

Receptor editing

Receptor editing is a process that occurs during the maturation of B cells, which are part of the adaptive immune system.

New!!: T cell receptor revision and Receptor editing · See more »

Regulatory T cell

The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.

New!!: T cell receptor revision and Regulatory T cell · See more »

T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

New!!: T cell receptor revision and T cell · See more »

T helper 17 cell

T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).

New!!: T cell receptor revision and T helper 17 cell · See more »

T-cell receptor

The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

New!!: T cell receptor revision and T-cell receptor · See more »

Thymus

The thymus is a specialized primary lymphoid organ of the immune system.

New!!: T cell receptor revision and Thymus · See more »

V(D)J recombination

V(D)J recombination is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation.

New!!: T cell receptor revision and V(D)J recombination · See more »

References

[1] https://en.wikipedia.org/wiki/T_cell_receptor_revision

OutgoingIncoming
Hey! We are on Facebook now! »