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The RNAi Consortium

Index The RNAi Consortium

The RNAi Consortium, or TRC, is a public-private partnership whose mission is to create libraries of small hairpin RNAs (shRNAs) for 15'000 human and 15'000 mouse genes. [1]

26 relations: Ampicillin, Antimicrobial resistance, Bacteria, BLAST, Broad Institute, Coding region, Empirical research, Gene, Harvard University, Immortalised cell line, Lentivirus, Mammal, Massachusetts Institute of Technology, National Center for Biotechnology Information, Plasmid, Public–private partnership, Puromycin, RNA interference, Short hairpin RNA, Sigma-Aldrich, Three prime untranslated region, Transcription (biology), Transcriptome, Transfection, Unigene Laboratories, Viral vector.

Ampicillin

Ampicillin is an antibiotic used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis.

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Antimicrobial resistance

Antimicrobial resistance (AMR or AR) is the ability of a microbe to resist the effects of medication that once could successfully treat the microbe.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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BLAST

In bioinformatics, BLAST for Basic Local Alignment Search Tool is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA sequences.

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Broad Institute

The Eli and Edythe L. Broad Institute of MIT and Harvard, often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States.

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Coding region

The coding region of a gene, also known as the CDS (from CoDing Sequence), is that portion of a gene's DNA or RNA that codes for protein.

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Empirical research

Empirical research is research using empirical evidence.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Harvard University

Harvard University is a private Ivy League research university in Cambridge, Massachusetts.

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Immortalised cell line

An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.

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Lentivirus

Lentivirus (lente-, Latin for "slow") is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in the human and other mammalian species.

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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Massachusetts Institute of Technology

The Massachusetts Institute of Technology (MIT) is a private research university located in Cambridge, Massachusetts, United States.

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National Center for Biotechnology Information

The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).

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Plasmid

A plasmid is a small DNA molecule within a cell that is physically separated from a chromosomal DNA and can replicate independently.

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Public–private partnership

A public–private partnership (PPP, 3P or P3) is a cooperative arrangement between two or more public and private sectors, typically of a long-term nature.

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Puromycin

Puromycin is an antibiotic protein synthesis inhibitor which causes premature chain termination during translation.

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RNA interference

RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules.

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Short hairpin RNA

A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).

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Sigma-Aldrich

Sigma-Aldrich Corporation is an American chemical, life science and biotechnology company owned by Merck KGaA.

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Three prime untranslated region

In molecular genetics, the three prime untranslated region (3'-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Transcriptome

The transcriptome is the set of all RNA molecules in one cell or a population of cells.

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Transfection

Transfection is the process of deliberately introducing naked or purified nucleic acids into eukaryotic cells.

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Unigene Laboratories

Unigene Laboratories (OTC:UGNE) was a biopharmaceutical company, engaged in the research and development of peptides for medical purposes.

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Viral vector

Viral vectors are tools commonly used by molecular biologists to deliver genetic material into cells.

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References

[1] https://en.wikipedia.org/wiki/The_RNAi_Consortium

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