37 relations: Apoptosis, Autoimmunity, BCL2L11, C-C chemokine receptor type 7, CCR9, CD1, CD117, CD2, CD34, CD4, CD44, CD5 (protein), CD7, CD8, Chemokine, Chemokine receptor, Circulatory system, Clonal anergy, DiGeorge syndrome, Haematopoiesis, Hematopoietic stem cell, IL2RA, Lymphoma, Major histocompatibility complex, Notch proteins, Notch signaling pathway, P-selectin, Peptide, Peripheral tolerance, Progenitor cell, Regulatory T cell, T cell, T-cell receptor, Thymocyte, Thymus, Thymus transplantation, V(D)J recombination.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues.
Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.
C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.
C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.
Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene.
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells.
CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species.
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration.
CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a.
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR).
Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.
Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine.
The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.
Anergy is a term in immunobiology that describes a lack of reaction by the body's defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance.
DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a syndrome caused by the deletion of a small segment of chromosome 22.
Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.
Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.
Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).
The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.
Notch proteins are a family of Type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans.
The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.
P-selectin is a protein that in humans is encoded by the SELP gene.
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
Peripheral tolerance is the second branch of immunological tolerance, after central tolerance.
A progenitor cell is a biological cell that, like a stem cell, has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its "target" cell.
The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
Thymocytes are hematopoietic progenitor cells present in the thymus.
The thymus is a specialized primary lymphoid organ of the immune system.
Thymus transplantation is a form of organ transplantation where the thymus is moved from one body to another.
V(D)J recombination is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation.