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59 relations: Alteplase, Alternative splicing, American Heart Association, Aminocaproic acid, Amputation, Bleeding, Blood vessel, Catalysis, Cell migration, Central venous catheter, Chinese hamster ovary cell, Chromosome 8, Comorbidity, Complementary DNA, Desmoteplase, Dihydrofolate reductase, Embolism, Endothelium, Enzyme, Evidence-based medicine, Fibrin, Fibrinogen alpha chain, Frostbite, Gene, Genomic library, Heparin, Hyperfibrinolysis, Immunoprecipitation, Industrial fermentation, Lacunar stroke, LDL-receptor-related protein-associated protein, LRP1, Medicine, Medicines and Healthcare products Regulatory Agency, Messenger RNA, Methotrexate, Myocardial infarction, Plasmid, Plasmin, Plasminogen activator inhibitor-1, Primary transcript, Protease, Protein, Protein–protein interaction, Pulmonary embolism, Recombinant DNA, Reteplase, Reverse transcriptase, Sequence analysis, Serine protease, ..., SERPINI1, Stroke, Tenecteplase, Thrombolysis, Thrombosis, Thrombus, Tissue remodeling, Ultrasound-enhanced systemic thrombolysis, Warfarin. Expand index (9 more) »
Alteplase
Alteplase (trade names Activase, Actilyse) is a thrombolytic drug, used to treat acute myocardial infarctions (heart attacks) and other severe conditions caused by blood clotting by breaking up the blood clots that cause them.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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American Heart Association
The American Heart Association (AHA) is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke.
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Aminocaproic acid
Aminocaproic acid (also known as ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue.
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Amputation
Amputation is the removal of a limb by trauma, medical illness, or surgery.
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Bleeding
Bleeding, also known as hemorrhaging or haemorrhaging, is blood escaping from the circulatory system.
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Blood vessel
The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.
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Catalysis
Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.
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Cell migration
Cell migration is a central process in the development and maintenance of multicellular organisms.
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Central venous catheter
A central venous catheter (CVC), also known as a central line, central venous line, or central venous access catheter, is a catheter placed into a large vein.
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Chinese hamster ovary cell
Chinese hamster ovary (CHO) cells are an epithelial cell line derived from the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of therapeutic proteins.
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Chromosome 8
Chromosome 8 is one of the 23 pairs of chromosomes in humans.
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Comorbidity
In medicine, comorbidity is the presence of one or more additional diseases or disorders co-occurring with (that is, concomitant or concurrent with) a primary disease or disorder; in the countable sense of the term, a comorbidity (plural comorbidities) is each additional disorder or disease.
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Complementary DNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.
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Desmoteplase
Desmoteplase is a novel, highly fibrin-specific "clot-busting" (thrombolytic) drug in development that reached phase III clinical trials.
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Dihydrofolate reductase
Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.
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Embolism
An embolism is the lodging of an embolus, a blockage-causing piece of material, inside a blood vessel.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Evidence-based medicine
Evidence-based medicine (EBM) is an approach to medical practice intended to optimize decision-making by emphasizing the use of evidence from well-designed and well-conducted research.
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Fibrin
Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.
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Fibrinogen alpha chain
Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.
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Frostbite
Frostbite occurs when exposure to low temperatures causes freezing of the skin or other tissues.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Genomic library
A genomic library is a collection of the total genomic DNA from a single organism.
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Heparin
Heparin, also known as unfractionated heparin (UFH), is medication which is used as an anticoagulant (blood thinner).
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Hyperfibrinolysis
The fibrinolysis system is responsible for removing blood clots.
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Immunoprecipitation
Immunoprecipitation (IP) is the technique of precipitating a protein antigen out of solution using an antibody that specifically binds to that particular protein.
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Industrial fermentation
Industrial fermentation is the intentional use of fermentation by microorganisms such as bacteria and fungi as well as eukaryotic cells like CHO cells and insect cells, to make products useful to humans.
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Lacunar stroke
Lacunar stroke or lacunar infarct (LACI) is the most common type of ischaemic stroke, and results from the occlusion of small penetrating arteries that provide blood to the brain's deep structures.
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LDL-receptor-related protein-associated protein
Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene.
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LRP1
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis.
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Medicine
Medicine is the science and practice of the diagnosis, treatment, and prevention of disease.
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Medicines and Healthcare products Regulatory Agency
The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department of Health and Social Care in the United Kingdom which is responsible for ensuring that medicines and medical devices work and are acceptably safe.
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Messenger RNA
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
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Methotrexate
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.
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Myocardial infarction
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
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Plasmid
A plasmid is a small DNA molecule within a cell that is physically separated from a chromosomal DNA and can replicate independently.
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Plasmin
Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.
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Plasminogen activator inhibitor-1
Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene.
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Primary transcript
A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs.
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Protease
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Pulmonary embolism
Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism).
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Recombinant DNA
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.
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Reteplase
Reteplase (trade names Retavase, Rapilysin) is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them.
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Reverse transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.
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Sequence analysis
In bioinformatics, sequence analysis is the process of subjecting a DNA, RNA or peptide sequence to any of a wide range of analytical methods to understand its features, function, structure, or evolution.
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Serine protease
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site.
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SERPINI1
Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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Tenecteplase
Tenecteplase (sold under the trade name TNKase) is an enzyme used as a thrombolytic drug.
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Thrombolysis
Thrombolysis is the breakdown (lysis) of blood clots formed in blood vessels, using medication.
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Thrombosis
Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
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Thrombus
A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.
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Tissue remodeling
Tissue remodeling is the reorganization or renovation of existing tissues.
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Ultrasound-enhanced systemic thrombolysis
Ultrasound-enhanced systemic thrombolysis (UEST) is a medical technology that uses ultrasound to enhance the effects of thrombolytic drugs.
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Warfarin
Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner).
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Redirects here:
ATC code B01AD02, ATC code S01XA13, ATCvet code QB01AD02, ATCvet code QS01XA13, EC 3.4.21.68, PLAT (gene), R-tPA, Recombinant tPA, Recombinant tissue plasminogen activator, Recombinant tissue plasminogen activators, Recombinant tpa, T-PA, T-Plasminogen activator, T-pa, T-plasminogen activator, Tissue plasminogen Activator, Tissue-plasminogen activator, Tissue-type plasmogen activator.
References
[1] https://en.wikipedia.org/wiki/Tissue_plasminogen_activator
