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Tretinoin, also known as all-trans retinoic acid (ATRA), is medication used for the treatment of acne and acute promyelocytic leukemia. [1]

39 relations: Acne, Acute promyelocytic leukemia, Albert Kligman, Anthracycline, Boxed warning, Cellular differentiation, Cis–trans isomerism, Collagen, Dermis, Epithelium, Erythromycin, Erythromycin/isotretinoin, Generic drug, Health system, Hypercholesterolemia, Hypertriglyceridemia, Hypervitaminosis A, Idiopathic intracranial hypertension, Isotretinoin, James Fulton (dermatologist), Leukocytosis, Management of hair loss, Minoxidil, National Health Service, Natural language, Paresthesia, Phlebitis, PIN1, Pregnancy, Promyelocyte, Retinoic acid, Retinoic acid syndrome, Retinoid, Shortness of breath, Stretch marks, Talarozole, Thrombosis, WHO Model List of Essential Medicines, Yale University Press.


Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.

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Acute promyelocytic leukemia

Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells.

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Albert Kligman

Albert Montgomery Kligman (March 17, 1916 – February 9, 2010) was a dermatologist who co-invented Retin-A, the acne medication, with James Fulton in 1969.

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Anthracyclines are a class of drugs used in cancer chemotherapy extracted from Streptomyces bacterium such as Streptomyces peucetius var.

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Boxed warning

In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears on the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Cis–trans isomerism

Cis–trans isomerism, also known as geometric isomerism or configurational isomerism, is a term used in organic chemistry.

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Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

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The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain.

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Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

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Erythromycin is an antibiotic useful for the treatment of a number of bacterial infections.

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Erythromycin/isotretinoin (trade name Isotrexin) is a topical gel with two active ingredients: erythromycin 2% w/w and isotretinoin 0.05% w/w with a primary indication for the treatment of moderate acne vulgaris.

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Generic drug

A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.

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Health system

A health system, also sometimes referred to as health care system or as healthcare system, is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.

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Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood.

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Hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant fatty molecule in most organisms.

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Hypervitaminosis A

Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A. Symptoms arise as a result of altered bone metabolism and altered metabolism of other fat-soluble vitamins.

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Idiopathic intracranial hypertension

Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (pressure around the brain) without a detectable cause.

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Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane or Roaccutane), is a medication primarily used to treat severe acne.

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James Fulton (dermatologist)


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Leukocytosis is white cells (the leukocyte count) above the normal range in the blood.

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Management of hair loss

The management of hair loss, also known as alopecia or baldness, may include medications and surgery.

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No description.

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National Health Service

The National Health Service (NHS) is the name used for each of the public health services in the United Kingdom – the National Health Service in England, NHS Scotland, NHS Wales, and Health and Social Care in Northern Ireland – as well as a term to describe them collectively.

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Natural language

In neuropsychology, linguistics, and the philosophy of language, a natural language or ordinary language is any language that has evolved naturally in humans through use and repetition without conscious planning or premeditation.

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Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.

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Phlebitis or venitis is the inflammation of a vein, usually in the legs.

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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene.

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Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

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A promyelocyte (or progranulocyte) is a granulocyte precursor, developing from the myeloblast and developing into the myelocyte.

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Retinoic acid

Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development.

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Retinoic acid syndrome

Retinoic acid syndrome (RAS) is a potentially life-threatening complication observed in patients with acute promyelocytic leukemia (APML) and first thought to be specifically associated with all-''trans'' retinoic acid (ATRA) (also known as tretinoin) treatment.

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The retinoids are a class of chemical compounds that are vitamers of vitamin A or are chemically related to it.

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Shortness of breath

Shortness of breath, also known as dyspnea, is the feeling that one cannot breathe well enough.

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Stretch marks

Stretch marks, also known as striae, are a form of scarring on the skin with an off-color hue.

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Talarozole (formerly R115866, planned trade name Rambazole) was an investigational drug for the treatment of acne, psoriasis and other keratinization disorders.

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Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

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WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.

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Yale University Press

Yale University Press is a university press associated with Yale University.

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Redirects here:

A-Ret, ATC code D10AD01, ATC code L01XX14, ATCvet code QD10AD01, ATCvet code QL01XX14, ATRA, Aberel, Aberela, Airol, Aknefug, Aknoten, All-trans retinoic acid, All-trans-retinoic acid, Atra-IV, Atralin, Dermairol, Eudyna, Lsotretinoin, Refissa, Retacnyl, Retin A, Retin-A, Retin-A Micro, Retin-A-Micro, Retino-A, Retisol-A, Stieva-A, Stieva-a Forte, Vesanoid, Vitinoin.


[1] https://en.wikipedia.org/wiki/Tretinoin

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