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Trodusquemine

Index Trodusquemine

Trodusquemine is an aminosterol (polyamine steroid conjugate) that inhibits protein tyrosine phosphatase 1B (PTP1B) activity. [1]

Table of Contents

  1. 30 relations: Allosteric regulation, American Chemical Society, Angiogenesis inhibitor, Anti-obesity medication, Antimicrobial, Anxiolytic, Atherosclerosis, Blood sugar level, Caenorhabditis elegans, Chemotherapy, Cholestane, Cholesterol, Dopamine transporter, Geroprotector, IC50, Insulin receptor, LDL receptor, Neuroprotection, Norepinephrine transporter, Ob/ob mouse, Parkinson's disease, Polyamine, PTPN1, Regeneration (biology), Spermidine, Spermine, Spiny dogfish, Squalamine, Squaliformes, Steroid.

  2. Cholestanes
  3. Polyamines

Allosteric regulation

In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.

See Trodusquemine and Allosteric regulation

American Chemical Society

The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry.

See Trodusquemine and American Chemical Society

Angiogenesis inhibitor

An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis).

See Trodusquemine and Angiogenesis inhibitor

Anti-obesity medication

Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat.

See Trodusquemine and Anti-obesity medication

Antimicrobial

An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth (bacteriostatic agent).

See Trodusquemine and Antimicrobial

Anxiolytic

An anxiolytic (also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety.

See Trodusquemine and Anxiolytic

Atherosclerosis

Atherosclerosis is a pattern of the disease arteriosclerosis, characterized by development of abnormalities called lesions in walls of arteries.

See Trodusquemine and Atherosclerosis

Blood sugar level

The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood.

See Trodusquemine and Blood sugar level

Caenorhabditis elegans

Caenorhabditis elegans is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments.

See Trodusquemine and Caenorhabditis elegans

Chemotherapy

Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.

See Trodusquemine and Chemotherapy

Cholestane

Cholestane is a saturated tetracyclic triterpene. Trodusquemine and Cholestane are Cholestanes.

See Trodusquemine and Cholestane

Cholesterol

Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Trodusquemine and Cholesterol are Cholestanes.

See Trodusquemine and Cholesterol

Dopamine transporter

The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.

See Trodusquemine and Dopamine transporter

Geroprotector

A geroprotector is a senotherapeutic that aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.

See Trodusquemine and Geroprotector

IC50

Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.

See Trodusquemine and IC50

Insulin receptor

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase.

See Trodusquemine and Insulin receptor

LDL receptor

The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).

See Trodusquemine and LDL receptor

Neuroprotection

Neuroprotection refers to the relative preservation of neuronal structure and/or function.

See Trodusquemine and Neuroprotection

Norepinephrine transporter

The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.

See Trodusquemine and Norepinephrine transporter

Ob/ob mouse

The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese.

See Trodusquemine and Ob/ob mouse

Parkinson's disease

Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.

See Trodusquemine and Parkinson's disease

Polyamine

A polyamine is an organic compound having more than two amino groups. Trodusquemine and polyamine are polyamines.

See Trodusquemine and Polyamine

PTPN1

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family.

See Trodusquemine and PTPN1

Regeneration (biology)

Regeneration in biology is the process of renewal, restoration, and tissue growth that makes genomes, cells, organisms, and ecosystems resilient to natural fluctuations or events that cause disturbance or damage.

See Trodusquemine and Regeneration (biology)

Spermidine

Spermidine is a polyamine compound found in ribosomes and living tissues and having various metabolic functions within organisms. Trodusquemine and Spermidine are polyamines and Secondary amines.

See Trodusquemine and Spermidine

Spermine

Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. Trodusquemine and Spermine are polyamines and Secondary amines.

See Trodusquemine and Spermine

Spiny dogfish

The spiny dogfish (Squalus acanthias), spurdog, mud shark, or piked dogfish is one of the best known species of the Squalidae (dogfish) family of sharks, which is part of the Squaliformes order.

See Trodusquemine and Spiny dogfish

Squalamine

Squalamine was discovered in a search for anti-microbial compounds in the tissues of primitive vertebrates. Trodusquemine and Squalamine are Cholestanes, polyamines, Secondary amines and Sulfate esters.

See Trodusquemine and Squalamine

Squaliformes

The Squaliformes are an order of sharks that includes about 126 species in seven families.

See Trodusquemine and Squaliformes

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

See Trodusquemine and Steroid

See also

Cholestanes

Polyamines

References

[1] https://en.wikipedia.org/wiki/Trodusquemine

Also known as MSI-1436.