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Ubiquitin-activating enzyme

Index Ubiquitin-activating enzyme

Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. [1]

16 relations: APPBP1, ATG7, Gigaxonin, Missense mutation, Proteasome, SAE1, SAE2, Spinal muscular atrophy, UBA1, UBE1C, UBE1DC1, UBE1L, UBE1L2, Ubiquitin, Ubiquitin ligase, Ubiquitin-conjugating enzyme.

APPBP1

NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.

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ATG7

Autophagy-related protein 7 is a protein in humans encoded by ATG7 gene.

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Gigaxonin

Gigaxonin also known as kelch-like protein 16 is a protein that in humans is encoded by the GAN gene.

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Missense mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

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Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.

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SAE1

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.

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SAE2

SAE2 is a gene of the yeast Saccharomyces cerevisiae, encoding for the a protein involved in the repair of DNA double strand breaks.

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Spinal muscular atrophy

Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterised by loss of motor neurons and progressive muscle wasting, often leading to early death.

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UBA1

Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene.

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UBE1C

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

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UBE1DC1

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.

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UBE1L

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.

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UBE1L2

Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.

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Ubiquitin

Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.

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Ubiquitin ligase

A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.

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Ubiquitin-conjugating enzyme

Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.

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Redirects here:

E1 enzyme.

References

[1] https://en.wikipedia.org/wiki/Ubiquitin-activating_enzyme

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