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Index UniProt

UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. [1]

72 relations: Accession number (bioinformatics), Active site, Algorithm, Alternative splicing, Amos Bairoch, Application programming interface, Biocurator, BLAST, CaBIG, Catalysis, Clustal, Cofactor (biochemistry), Consensus CDS Project, Creative Commons, Data redundancy, Database, DNA Data Bank of Japan, Ensembl genome database project, Enzyme, European Bioinformatics Institute, European Commission, European Molecular Biology Laboratory, European Patent Office, Exon, ExPASy, FASTA, FlyBase, Frameshift mutation, GenBank, Gene, General feature format, Genetic diversity, Genome project, H-Invitational, International Nucleotide Sequence Database Collaboration, International Protein Index, Ion, Japan Patent Office, Java (programming language), Margaret Oakley Dayhoff, Membrane topology, National Human Genome Research Institute, National Institutes of Health, Organism, Post-translational modification, Protein, Protein Data Bank, Protein domain, Protein family, Protein Information Resource, ..., Protein primary structure, Protein–protein interaction, Proteolysis, PubMed, RefSeq, Representational state transfer, Resource Description Framework, RNA editing, Rolf Apweiler, Saccharomyces Genome Database, Signal peptide, Species, Subcellular localization, Substrate (chemistry), Swiss Institute of Bioinformatics, The Arabidopsis Information Resource, Transmembrane domain, United States Patent and Trademark Office, Vertebrate and Genome Annotation Project, Wellcome Genome Campus, WormBase, XML. Expand index (22 more) »

Accession number (bioinformatics)

An accession number in bioinformatics is a unique identifier given to a DNA or protein sequence record to allow for tracking of different versions of that sequence record and the associated sequence over time in a single data repository.

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Active site

In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.

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In mathematics and computer science, an algorithm is an unambiguous specification of how to solve a class of problems.

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Alternative splicing

Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.

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Amos Bairoch

Amos Bairoch (born 22 November 1957) is a Swiss bioinformatician and Professor of Bioinformatics at the Department of Human Protein Sciences of the University of Geneva where he leads the CALIPHO group at the Swiss Institute of Bioinformatics (SIB) combining bioinformatics, curation, and experimental efforts to functionally characterize human proteins.

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Application programming interface

In computer programming, an application programming interface (API) is a set of subroutine definitions, protocols, and tools for building software.

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A biocurator is a professional scientist who curates, collects, annotates, and validates information that is disseminated by biological and model Organism Databases.

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In bioinformatics, BLAST for Basic Local Alignment Search Tool is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA sequences.

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The cancer Biomedical Informatics Grid (caBIG) was a US government program to develop an open source, open access information network called caGrid for secure data exchange on cancer research.

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Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Clustal is a series of widely used computer programs used in Bioinformatics for multiple sequence alignment.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Consensus CDS Project

The Consensus Coding Sequence (CCDS) Project is a collaborative effort to maintain a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assemblies.

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Creative Commons

Creative Commons (CC) is an American non-profit organization devoted to expanding the range of creative works available for others to build upon legally and to share.

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Data redundancy

In computer main memory, auxiliary storage and computer buses, data redundancy is the existence of data that is additional to the actual data and permits correction of errors in stored or transmitted data.

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A database is an organized collection of data, stored and accessed electronically.

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DNA Data Bank of Japan

The DNA Data Bank of Japan (DDBJ) is a biological database that collects DNA sequences.

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Ensembl genome database project

Ensembl genome database project is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent completion of the Human Genome Project.

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Enzymes are macromolecular biological catalysts.

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European Bioinformatics Institute

The European Bioinformatics Institute (EMBL-EBI) is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory (EMBL).

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European Commission

The European Commission (EC) is an institution of the European Union, responsible for proposing legislation, implementing decisions, upholding the EU treaties and managing the day-to-day business of the EU.

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European Molecular Biology Laboratory

The European Molecular Biology Laboratory (EMBL) is a molecular biology research institution supported by 25 member states, four prospect and two associate member states.

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European Patent Office

The European Patent Office (EPO) is one of the two organs of the European Patent Organisation (EPOrg), the other being the Administrative Council.

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An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

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ExPASy is a bioinformatics resource portal operated by the SIB Swiss Institute of Bioinformatics and in particular the SIB Web Team.

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FASTA is a DNA and protein sequence alignment software package first described by David J. Lipman and William R. Pearson in 1985.

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FlyBase is an online bioinformatics database and the primary repository of genetic and molecular data for the insect family Drosophilidae.

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Frameshift mutation

A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.

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The GenBank sequence database is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations.

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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General feature format

The general feature format (gene-finding format, generic feature format, GFF) is a file format used for describing genes and other features of DNA, RNA and protein sequences.

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Genetic diversity

Genetic diversity is the total number of genetic characteristics in the genetic makeup of a species.

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Genome project

Genome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus) and to annotate protein-coding genes and other important genome-encoded features.

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the H-Invitational Database (H-InvDB) is a comprehensive annotation resource for human genes and transcripts.

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International Nucleotide Sequence Database Collaboration

The International Nucleotide Sequence Database Collaboration (INSDC, http://insdc.org) consists of a joint effort to collect and disseminate databases containing DNA and RNA sequences.

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International Protein Index

The International Protein Index (IPI) is a defunct protein database launched in 2001 by the European Bioinformatics Institute (EBI), and closed in 2011.

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An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).

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Japan Patent Office

The is a Japanese governmental agency in charge of industrial property right affairs, under the Ministry of Economy, Trade and Industry.

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Java (programming language)

Java is a general-purpose computer-programming language that is concurrent, class-based, object-oriented, and specifically designed to have as few implementation dependencies as possible.

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Margaret Oakley Dayhoff

Margaret Belle (Oakley) Dayhoff (March 11, 1925 – February 5, 1983) was an American physical chemist and a pioneer in the field of bioinformatics.

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Membrane topology

Topology of a transmembrane protein refers to orientations (locations of N- and C-termini) of membrane-spanning segments with respect to the inner or outer sides of the biological membrane occupied by the protein.

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National Human Genome Research Institute

NHGRI began as the Office of Human Genome Research in The Office of the Director in 1988.

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National Institutes of Health

The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research, founded in the late 1870s.

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In biology, an organism (from Greek: ὀργανισμός, organismos) is any individual entity that exhibits the properties of life.

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Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein Data Bank

The Protein Data Bank (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Protein family

A protein family is a group of evolutionarily-related proteins.

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Protein Information Resource

The Protein Information Resource (PIR), located at Georgetown University Medical Center (GUMC), is an integrated public bioinformatics resource to support genomic and proteomic research, and scientific studies.

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Protein primary structure

Protein primary structure is the linear sequence of amino acids in a peptide or protein.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.

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PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics.

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The Reference Sequence (RefSeq) database is an open access, annotated and curated collection of publicly available nucleotide sequences (DNA, RNA) and their protein products.

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Representational state transfer

Representational State Transfer (REST) is an architectural style that defines a set of constraints and properties based on HTTP.

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Resource Description Framework

The Resource Description Framework (RDF) is a family of World Wide Web Consortium (W3C) specifications originally designed as a metadata data model.

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RNA editing

RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase.

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Rolf Apweiler

Rolf Apweiler is a director of European Bioinformatics Institute (EBI) part of the European Molecular Biology Laboratory (EMBL) with Ewan Birney.

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Saccharomyces Genome Database

The Saccharomyces Genome Database is a scientific database of the molecular biology and genetics of the yeast Saccharomyces cerevisiae, which is commonly known as baker's or budding yeast.

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Signal peptide

A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) present at the N-terminus of the majority of newly synthesized proteins that are destined towards the secretory pathway.

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In biology, a species is the basic unit of classification and a taxonomic rank, as well as a unit of biodiversity, but it has proven difficult to find a satisfactory definition.

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Subcellular localization

The cells of eukaryotic organisms are elaborately subdivided into functionally-distinct membrane-bound compartments.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Swiss Institute of Bioinformatics

The SIB Swiss Institute of Bioinformatics is an academic not-for-profit foundation which federates bioinformatics activities throughout Switzerland.

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The Arabidopsis Information Resource

The Arabidopsis Information Resource (TAIR) is a community resource and online model organism database of genetic and molecular biology data for the model plant Arabidopsis thaliana, commonly known as mouse-ear cress.

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Transmembrane domain

Transmembrane domain usually denotes a transmembrane segment of single alpha helix of a transmembrane protein.

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United States Patent and Trademark Office

The United States Patent and Trademark Office (USPTO) is an agency in the U.S. Department of Commerce that issues patents to inventors and businesses for their inventions, and trademark registration for product and intellectual property identification.

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Vertebrate and Genome Annotation Project

The Vertebrate Genome Annotation (VEGA) database is a biological database dedicated to assisting researchers in locating specific areas of the genome and annotating genes or regions of vertebrate genomes.

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Wellcome Genome Campus

The Wellcome Genome Campus is a scientific research campus built in the grounds of Hinxton Hall, Hinxton in Cambridgeshire, England.

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WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans and contains information about other related nematodes.

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In computing, Extensible Markup Language (XML) is a markup language that defines a set of rules for encoding documents in a format that is both human-readable and machine-readable.

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Redirects here:

Ebi8.uniprot.org, Swiss-Prot, SwissProt, Swissprot, TrEMBL, UniMES, UniProt Knowledgebase, UniProtKB, Uniprot, Www.uniprot.org.


[1] https://en.wikipedia.org/wiki/UniProt

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