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Methoxsalen

Index Methoxsalen

Methoxsalen (also called xanthotoxin, marketed under the trade names Oxsoralen, Deltasoralen, Meladinine) is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. [1]

45 relations: Afamelanotide, Ammi majus, Annulation, Apiaceae, Black Like Me, Carboxylic acid, Cinnamic acid, Coumarin, Dermatitis, Dimethylallyl pyrophosphate, Dizziness, Fitzpatrick scale, Furan, Furanocoumarin, Headache, Hydroxylation, Hypertension, Insomnia, John Howard Griffin, Lactone, List of IARC Group 1 carcinogens, Liver, Lymphoma, Marmesin, Medication, Mevalonate pathway, Monarda, Nausea, P-Coumaric acid, Phenylalanine, Phenylpropanoid, Phototoxicity, Psoralen, Psoralen synthase, Psoriasis, PUVA therapy, Rutaceae, S-Adenosyl methionine, Shikimic acid, Trans-cinnamate 4-monooxygenase, Ultraviolet, Umbellic acid, Umbelliferone, Vitiligo, Xanthotoxol O-methyltransferase.

Afamelanotide

Afamelanotide ((INN) (brand name Scenesse), also known as melanotan I (or melanotan-1), originally developed at the University of Arizona and now by Clinuvel Pharmaceuticals, is a synthetic peptide and analogue of the naturally occurring melanocortin peptide hormone α-melanocyte stimulating hormone (α-MSH) that has been shown to induce the production of darkening dermal pigmentation through melanogenesis and thereby subsequently reduce sun (UV) damage to UV light-exposed skin in preliminary research and human clinical trials. Its amino acid sequence is Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, and it is additionally known as -α-MSH, which is sometimes abbreviated as NDP-MSH or NDP-α-MSH (especially in the scientific literature). Afamelanotide is the International Nonproprietary Name for the molecule α-MSH initially researched and developed as melanotan-1 and later, CUV1647 (by Clinuvel). A marketing trade name for one brand of afamelanotide was approved in 2010 by the European Medicines Agency (EMA) Name Review Group (NRG) and the agency's Committee for Medicinal Products for Human Use (CHMP) as Scenesse (pronounced "sen-esse"). On May 5, 2010 the Italian Medicines Agency (AIFA, or Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful dermal photosensitivity stemming from the orphan disease erythropoietic protoporphyria (EPP). This approval allowed the drug to be immediately available for prescription in Italy and reimbursable under the country's national health system. Authorities in Switzerland have also allowed prescription of the drug for EPP with reimbursement approved by two unnamed insurers. Afamelanotide is currently being trialed in the form of a "grain of rice"-sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection-inducing agent for a series of light-related skin indications as well as a potential dermal repigmentation agent for vitiligo. Afamelanotide, as of October 24, 2014, has been approved by the EMA in Europe for the treatment of EPP. Clinuvel now intends to seek approval of afamelanotide in the United States. Unlicensed and untested powders sold as "melanotan" are found on the Internet and are reported to be used by tens of thousands of members of the general public for sunless tanning. Multiple regulatory bodies have warned consumers that the peptides may be unsafe and ineffective in usage, with one regulatory agency warning that consumers who purchase any product labeled "melanotan" risk buying a counterfeit drug. Clinuvel Pharmaceuticals, the developer of afamelanotide, and medical researchers have warned consumers that counterfeit products sold using the names "melanotan I and II", could "pose a hazard to public health". on counterfeit products. February 10, 2009. Clinuvel has stated publicly that products sold online as "melanotan" are not afamelanotide.

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Ammi majus

Ammi majus—commonly called bishop's weed, false bishop's weed, bullwort, greater ammi, lady's lace, Queen Anne's lace or laceflower—is a plant originating in the Nile River Valley which has white lace-like flower clusters.

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Annulation

In organic chemistry annulation (from the Latin anellus for "little ring"; occasionally annelation) is a chemical reaction in which a new ring is constructed on a molecule.

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Apiaceae

Apiaceae or Umbelliferae, is a family of mostly aromatic flowering plants named after the type genus Apium and commonly known as the celery, carrot or parsley family, or simply as umbellifers.

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Black Like Me

Black Like Me, first published in 1961, is a nonfiction book by white journalist John Howard Griffin recounting his journey in the Deep South of the United States, at a time when African-Americans lived under Racial Segregation.

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Carboxylic acid

A carboxylic acid is an organic compound that contains a carboxyl group (C(.

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Cinnamic acid

Cinnamic acid is an organic compound with the formula C6H5CHCHCO2H.

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Coumarin

Coumarin (2H-chromen-2-one) is a fragrant organic chemical compound in the benzopyrone chemical class, although it may also be seen as a subclass of lactones.

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Dermatitis

Dermatitis, also known as eczema, is a group of diseases that results in inflammation of the skin.

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Dimethylallyl pyrophosphate

Dimethylallyl pyrophosphate (DMAPP; or alternatively, dimethylallyl diphosphate (DMADP); also isoprenyl pyrophosphate) is an isoprenoid precursor.

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Dizziness

Dizziness is an impairment in spatial perception and stability.

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Fitzpatrick scale

The Fitzpatrick scale (also Fitzpatrick skin typing test; or Fitzpatrick phototyping scale) is a numerical classification schema for human skin color.

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Furan

Furan is a heterocyclic organic compound, consisting of a five-membered aromatic ring with four carbon atoms and one oxygen.

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Furanocoumarin

The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants.

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Headache

Headache is the symptom of pain anywhere in the region of the head or neck.

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Hydroxylation

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.

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Hypertension

Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

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John Howard Griffin

John Howard Griffin (June 16, 1920 – September 9, 1980) was an American journalist and author from Texas, who wrote about racial equality.

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Lactone

Lactones are cyclic esters of hydroxycarboxylic acids, containing a 1-oxacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.

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List of IARC Group 1 carcinogens

Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Marmesin

Marmesin (nodakenetin) is a chemical compound precursor in psoralen and linear furanocoumarins biosynthesis.

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Medication

A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Mevalonate pathway

The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria.

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Monarda

Monarda is a genus of flowering plants in the mint family, Lamiaceae.

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Nausea

Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.

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P-Coumaric acid

p-Coumaric acid is a hydroxycinnamic acid, an organic compound that is a hydroxy derivative of cinnamic acid.

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Phenylalanine

Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.

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Phenylpropanoid

The phenylpropanoids are a diverse family of organic compounds that are synthesized by plants from the amino acids phenylalanine and tyrosine.

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Phototoxicity

Phototoxicity, also called photoirritation, is a chemically induced skin irritation, requiring light, that does not involve the immune system.

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Psoralen

Psoralen (also called psoralene) is the parent compound in a family of natural products known as furocoumarins.

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Psoralen synthase

In enzymology, a psoralen synthase is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are (+)-marmesin, NADPH, H+, and O2, whereas its 4 products are psoralen, NADP+, acetone, and H2O.

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Psoriasis

Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin.

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PUVA therapy

PUVA (psoralen and ultraviolet A) is an ultraviolet light therapy treatment for eczema, psoriasis, graft-versus-host disease, vitiligo, mycosis fungoides, large-plaque parapsoriasis and cutaneous T-cell lymphoma using the sensitizing effects of the drug psoralen.

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Rutaceae

The Rutaceae are a family, commonly known as the rue in BoDD – Botanical Dermatology Database or citrus family, of flowering plants, usually placed in the order Sapindales.

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S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

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Shikimic acid

Shikimic acid, more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid.

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Trans-cinnamate 4-monooxygenase

In enzymology, a trans-cinnamate 4-monooxygenase is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are trans-cinnamate, NADPH, H+, and O2, whereas its 3 products are 4-hydroxycinnamate, NADP+, and H2O.

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Ultraviolet

Ultraviolet (UV) is electromagnetic radiation with a wavelength from 10 nm to 400 nm, shorter than that of visible light but longer than X-rays.

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Umbellic acid

Umbellic acid (2,4-dihydroxycinnamic acid) is a hydroxycinnamic acid.

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Umbelliferone

Umbelliferone, also known as 7-hydroxycoumarin, hydrangine, skimmetine, and beta-umbelliferone, is a natural product of the coumarin family.

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Vitiligo

Vitiligo is a long-term skin condition characterized by patches of the skin losing their pigment.

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Xanthotoxol O-methyltransferase

In enzymology, a xanthotoxol O-methyltransferase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are S-adenosyl methionine and xanthotoxol, whereas its two products are S-adenosylhomocysteine and O-methylxanthotoxol.

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Redirects here:

8-Methoxypsoralen, 8-Mop, 8-methoxy-psoralen, 8-methoxypsoralen, 8-mop, ATC code D05AD02, ATC code D05BA02, ATCvet code QD05AD02, ATCvet code QD05BA02, Ammodin, Ammoidin, Dltasoralen, Meladinin, Meladinine, Meladoxen, Meloxine, Methoxa-Dome, Methoxalen, Methoxaten, New-Meladinin, O-methylxanthotoxol, Oxoralen, Oxsolaren, Oxsoralen, Oxsoralen Lotion, Oxsoralen-Ultra, Oxypsoralen, Proralone-Mop, Psoralen-Mop, Puvalen, Puvamet, Ultra Mop, Ultramop Lotion, Uvadex, Xanthotoxin, Xanthotoxine, Zanthotoxin.

References

[1] https://en.wikipedia.org/wiki/Methoxsalen

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